Dechlorination and demethylation of ochratoxin A enhance blocking activity of PXR activation, suppress PXR expression and reduce cytotoxicity.

abstract：:Micronucleus (MN) induction by azidothymidine (AZT) in B and T lymphocytes was analyzed by a recently developed MAC (morphology-antibody-chromosome) method which allows the immunologic identification of different cell lineages. An increased frequency of MN in AZT-treated cultures compared with controls was observed. C...

journal_title：Toxicology letters

authors： Stern M,Cid MG,Larripa I,Slavutsky I

更新日期：1994-02-01 00:00:00

abstract：:Using equimolar quantities of 2 chemical allergens, toluene diisocyanate (TDI), noted for its ability to cause respiratory hypersensitivity, and dinitrochlorobenzene (DNCB), noted for its dermal sensitizing activity, the mouse was evaluated as a possible model to indicate respiratory hypersensitivity. A previously pub...

journal_title：Toxicology letters

authors： Satoh T,Kramarik JA,Tollerud DJ,Karol MH

更新日期：1995-06-01 00:00:00

abstract：:The present study was undertaken in an attempt to reconcile the seemingly conflicting observations that glutathione-dependent biotransformation of methyl parathion (O,O-dimethyl-O-(4-nitrophenyl)phosphorothionate) by hepatic supernatant or partially purified glutathione S-transferases occurs in vitro, but not to any s...

journal_title：Toxicology letters

authors： Huang YS,Sultatos LG

更新日期：1993-06-01 00:00:00

abstract：:CYP2E1 metabolizes 1,3-butadiene (BD) into genotoxic and possibly carcinogenic 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 1,2-epoxy-3,4-butanediol (EB-diol). The dose response of DNA and protein adducts derived from BD metabolites increases linearly at low BD exposures and then saturates at higher expos...

journal_title：Toxicology letters

authors： Pianalto KM,Hartman JH,Boysen G,Miller GP

更新日期：2013-11-25 00:00:00

abstract：:To test the toxicity of some substances, known to affect the nervous system i.e. organic solvents, heavy metals and DDT, their ability to cause cell detachment of cultured mouse neuroblastoma cells was investigated. A TD25 value was obtained by graphic estimation of the concentration needed to cause 25% of the total c...

journal_title：Toxicology letters

authors： Peterson A,Lewné M,Walum E

更新日期：1981-10-01 00:00:00

abstract：:Plants can metabolize the Fusarium mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β-D-glucoside (D3G). D3G might be cleaved during digestion, thus increasing the total DON burden of an individual. Due to a lack of in vivo data, D3G has not been included in the various regulatory limits...

journal_title：Toxicology letters

authors： Nagl V,Woechtl B,Schwartz-Zimmermann HE,Hennig-Pauka I,Moll WD,Adam G,Berthiller F

更新日期：2014-08-17 00:00:00

abstract：:Rhesus monkeys exposed to marijuana smoke either 7 or 2 days/weeks (HI and LO groups, respectively), or ethanol-extracted marijuana smoke for 7 days/week (EM) or sham treatment (SH) for 1 year were sacrificed 7 months following the last exposure. Pulmonary levels of carcinogen-DNA adducts were determined. Although mea...

journal_title：Toxicology letters

authors： Talaska G,Schamer M,Bailey JR,Ali SF,Scallet AC,Slikker W Jr,Paule MG

更新日期：1992-12-01 00:00:00

abstract：:Phytosterols (PS) are naturally occurring compounds present in food products of plant origin. Due to reported positive health effects, some food products are also enriched with PS. In the same way as cholesterol is oxidised, PS also oxidise to a variety of oxidation products (POPs). The biological effects and safety a...

journal_title：Toxicology letters

authors： Abramsson-Zetterberg L,Svensson M,Johnsson L

更新日期：2007-09-10 00:00:00

abstract：:Metal oxide NPs are abundantly produced in nanotech industries and are emitted in several combustion processes, suggesting the need to characterize their toxic impact on the human respiratory system. The acute toxicity and the morphological changes induced by copper oxide and titanium dioxide NPs (nCuO and nTiO₂) on t...

journal_title：Toxicology letters

authors： Moschini E,Gualtieri M,Colombo M,Fascio U,Camatini M,Mantecca P

更新日期：2013-10-24 00:00:00

abstract：:Aggregation of α-synuclein (α-syn) in the brain is a defining pathological feature of neurodegenerative disorders classified as synucleinopathies. They include Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Occupational and environmental exposure to manganese (Mn) is asso...

journal_title：Toxicology letters

authors： Verina T,Schneider JS,Guilarte TR

更新日期：2013-03-13 00:00:00

abstract：:The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseas...

journal_title：Toxicology letters

authors： Luster MI,Simeonova PP,Gallucci RM,Bruccoleri A,Blazka ME,Yucesoy B

更新日期：2001-03-31 00:00:00

abstract：:Inorganic arsenic has strong human carcinogenic potential, but the availability of an animal model to study toxicity is extremely limited. Here, we used the transgenic zebrafish line Tg(k18(2.9):RFP) as an animal model to study arsenite toxicity. This line was chosen because the red fluorescent protein (RFP) is expres...

journal_title：Toxicology letters

authors： Wang YH,Chen YH,Wu TN,Lin YJ,Tsai HJ

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVES:Determine uptake of furan, a potential human carcinogen, in waterpipe tobacco (WPT) smokers in home settings. METHODS:We analysed data from a US convenience sample of 50 exclusive WPT smokers, mean age 25.3 years, and 25 non-smokers, mean age 25.5 years. For WPT smokers, data were collected at a home visit ...

journal_title：Toxicology letters

authors： Kassem NOF,Peterson LA,Liles S,Kassem NO,Zaki FK,Lui KJ,Vevang KR,Dodder NG,Hoh E,Hovell MF

更新日期：2020-10-15 00:00:00

abstract：:Acrylonitrile (AN) showed spectral interaction with hepatic microsomes from mouse, rat and man. Whereas human and rat liver microsomes resulted in ligand AN-binding spectra, mouse liver microsomes behaved differently. Hepatic microsomes from phenobarbital-treated mice with AN showed a type I substrate binding; ligand ...

journal_title：Toxicology letters

authors： Appel KE,Peter H,Bolt M,Bolt HM

更新日期：1981-02-01 00:00:00

abstract：:A protective effect of preadministration of the metals Cu, Bi, Zn, Hg, Cd, Ni or Co, against lethal toxicity of cis-diamminedichloroplatinum (Cisplatin; CDDP) was observed in mice. However, the protective effect seems not always to correlate with metallothionein (MT) levels in the liver and kidney of mice treated with...

journal_title：Toxicology letters

authors： Naganuma A,Satoh M,Koyama Y,Imura N

更新日期：1985-02-01 00:00:00

abstract：:The aim of this study was to test the influence of nanoparticle size and surface area (SA) on cytokine secretion by co-cultures of pulmonary epithelial cells (A549), macrophages (differentiated THP-1 cells) and endothelium cells (EA.hy926) in a two-compartment system. We used monodisperse amorphous silica nanoparticle...

journal_title：Toxicology letters

authors： Napierska D,Thomassen LC,Vanaudenaerde B,Luyts K,Lison D,Martens JA,Nemery B,Hoet PH

更新日期：2012-06-01 00:00:00

abstract：:Fenitrothion (FNT) is used worldwide in agricultural and public health settings. Spermatogenesis is a toxicological target of FNT under high-dose exposure. Although anti-androgenic action is postulated to be the mechanism associated with this toxicity, few studies have examined histopathology of androgen-dependent mal...

journal_title：Toxicology letters

authors： Miyake M,Ito Y,Suzuki H,Tomizawa M,Sato H,Liu M,Okamura A,Nakajima T,Ohtani K,Takino H,Inagaki H,Kamijima M

更新日期：2018-03-15 00:00:00

abstract：:In the present study, the emetic effect of the anticancer drug cisplatin, and protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental setting involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals an...

journal_title：Toxicology letters

authors： Navarra P,Martire M,del Carmine R,Pozzoli G,Preziosi P

更新日期：1992-12-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a stable man-made compound with many industrial and commercial uses. Recently, however, concern has been raised that it may induce various toxicological effects such as hepatotoxicity, immunotoxicity, and developmental toxicity. Because levels of circulating microRNAs (miRNAs) can be a...

journal_title：Toxicology letters

authors： Yan S,Wang J,Zhang W,Dai J

更新日期：2014-01-03 00:00:00

abstract：:The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most potent risk factor among tobacco-related carcinogens in lung cancer progression and outcomes. Although genetic mutations and chromosome instability have been detected in NNK-induced lung tumors, the oncogenic mechanisms o...

journal_title：Toxicology letters

authors： Park JE,Jang YL,Jang CY

更新日期：2017-11-05 00:00:00

abstract：:The effect of a single intravenous (i.v.) injection of cadmium nitrate was investigated in livers of male Wistar rats. A significant increase in liver weight, accompanied by an elevation of total hepatic DNA content was observed. DNA synthesis as measured by the incorporation of [3H]thymidine, was found to be 6 times ...

journal_title：Toxicology letters

authors： Ledda-Columbano GM,Columbano A,Coni PP,Vargiu M,Liguori C,Pani P

更新日期：1984-12-01 00:00:00

abstract：:N-cadherin has known to be involved in tumor progression and metastasis. However, it is still obscure about the signaling pathway involving in the processing of N-cadherin. Thus, we examined which signaling pathway plays a major role in the processing of N-cadherin in C6 glioma cells following treatment of cadmium (Cd...

journal_title：Toxicology letters

authors： Jo C,Koh YH

更新日期：2013-10-24 00:00:00

abstract：:Toluene, an industrial organic solvent, is voluntarily inhaled as drug of abuse. Because inhibition of N-methyl-d-aspartate (NMDA) receptors is one of the possible mechanisms underlying developmental neurotoxicity of toluene, the purpose of the present study was to examine the effects of toluene exposure during two ma...

journal_title：Toxicology letters

authors： Chen HH,Lin YR,Chan MH

更新日期：2011-09-10 00:00:00

abstract：:As information regarding microarray data sets and toxicogenomic biomarkers grows rapidly, the process of analyzing data and interpreting the results is increasingly complicated. To facilitate data analysis, a simple expression ratio-based scoring method called the TGP1 score was previously proposed [Kiyosawa, N., Shiw...

journal_title：Toxicology letters

authors： Kiyosawa N,Ando Y,Watanabe K,Niino N,Manabe S,Yamoto T

更新日期：2009-07-24 00:00:00

abstract：:Haemolysis by chrysotile fibres may be related to an adsorption of the red blood cell (RBC) membranes on the fibres and not to an interaction between magnesium (Mg) from the fibres and sialic acid from RBC. This was demonstrated using neuraminidase (NANASE)-treated RBC and Mg-depleted chrysotile fibres. The mechanism ...

journal_title：Toxicology letters

authors： Jaurand MC,Magne L,Bignon J

更新日期：1983-02-01 00:00:00

abstract：:The chronic toxic effects of chromium (2.6 mg/1) on the carbohydrate metabolism of a teleost fish, Channa punctatus were examined after 60 and 120 days of exposure. After 60 days the lactic acid content of blood and muscles was increased but liver lactic acid content decreased. Liver glycogen was also depleted. The ac...

journal_title：Toxicology letters

authors： Sastry KV,Sunita K

更新日期：1983-04-01 00:00:00

abstract：:Welding fumes contain various toxic metals including chromium (Cr), nickel (Ni) and manganese (Mn). An assessment of the risk to health of local and systemic exposure to welding fumes requires the assessment of both external and internal doses. The aims of this study were to test the relevance in small and medium size...

journal_title：Toxicology letters

authors： Persoons R,Arnoux D,Monssu T,Culié O,Roche G,Duffaud B,Chalaye D,Maitre A

更新日期：2014-12-01 00:00:00

abstract：:Exercising volunteers exposed in chambers to as little as 80 ppb O3 for several hours exhibit impaired lung function and irritative lower airway symptoms. Comparable changes occur among children and young adults exposed to summer smog containing O3. Intensity of the response is reproducible but varies widely among ind...

journal_title：Toxicology letters

authors： Bromberg PA,Koren HS

更新日期：1995-12-01 00:00:00

abstract：:Mechanisms of zinc (Zn) toxicity are incompletely understood and data regarding potential endocrine alterations in Zn toxicity are scarce. To examine mechanisms of Zn toxicity, day-old chicks were pair-fed diets containing 5280 ppm (Hz) or 73 ppm (CON) Zn. Impaired postnatal growth, independent of feed consumption, an...

journal_title：Toxicology letters

authors： Dean CE,Hargis BM,Hargis PS

更新日期：1991-08-01 00:00:00

abstract：:Acrylonitrile (ACN) is a widely used intermediate in the manufacture of plastics, acrylic fibers, synthetic rubbers and resins that are used in a variety of products including food containers and medical devices. ACN is a possible human carcinogen and a documented animal carcinogen, with the stomach being an important ...

journal_title：Toxicology letters

authors： Hamdy NM,Al-Abbasi FA,Alghamdi HA,Tolba MF,Esmat A,Abdel-Naim AB

更新日期：2012-01-25 00:00:00