Abstract:
:Trichothecenes are mycotoxins which produce lethal toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a highly lethal T-2 toxicosis. These data also suggest that PAF is an important mediator of this unique toxicosis.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Feuerstein G,Leader P,Siren AL,Braquet Pdoi
10.1016/0378-4274(87)90008-7subject
Has Abstractpub_date
1987-10-01 00:00:00pages
271-4issue
3eissn
0378-4274issn
1879-3169pii
0378-4274(87)90008-7journal_volume
38pub_type
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journal_title:Toxicology letters
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abstract::Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocyte-derived GC-2 cel...
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journal_title:Toxicology letters
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更新日期:2009-08-25 00:00:00
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journal_title:Toxicology letters
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更新日期:2000-06-05 00:00:00
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2011.10.005
更新日期:2012-01-05 00:00:00
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更新日期:2006-05-05 00:00:00
abstract::There is a trend towards increasing doses of pralidoxime to treat human organophosphate poisonings that may have relevance in subpopulations. Indeed, pralidoxime is eliminated unchanged by the renal route. This study assesses the effect of renal failure on the kinetics of pralidoxime in a rat model of acute renal fail...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.10.022
更新日期:2009-01-10 00:00:00
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journal_title:Toxicology letters
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更新日期:1980-02-01 00:00:00
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doi:10.1016/0378-4274(80)90042-9
更新日期:1980-12-01 00:00:00
abstract::Although CSL box jellyfish antivenom (AV) remains the primary treatment for Chironex fleckeri envenoming, there has been considerable debate regarding its clinical effectiveness. Animal studies have shown that AV is largely ineffective in preventing C. fleckeri-induced cardiovascular collapse. This study examined the ...
journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2009.02.008
更新日期:2009-06-01 00:00:00
abstract::Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellula...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2001-09-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(87)90197-4
更新日期:1987-05-01 00:00:00
abstract::Benzophenone-3 (2-hydroxy-4-methoxybenzophenone, BZ-3) is a UV absorber that is used extensively in medicine, cosmetics and industry as a sunscreen and color fastener. Exposure to the chemical is through the dermal and oral route. Bioavailability of the chemical absorbed through the skin is different from that seen th...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90101-5
更新日期:1994-08-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2012.03.002
更新日期:2012-06-01 00:00:00
abstract::2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant that could induce serious toxic effects in both humans and rodents. Some studies suggested that TCDD exposure may facilitate the activation of hepatic stellate cells (HSCs) and liver injury. However, the underlying molecular mechanism b...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.03.013
更新日期:2017-05-05 00:00:00
abstract::Whole-body inhalation exposures to N,N-dimethylacetamide (DMAC) were conducted with male rats (Crl:CD BR) and mice (Crl:CD-1 (ICR)BR). Exposure concentrations were 50, 150, 300 and 500 ppm. The exposure routines consisted of single 1-, 3-, or 6-h exposures and ten 6-h exposures (10 exposure days in 2 weeks). Area unde...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90061-2
更新日期:1994-09-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2016.01.003
更新日期:2016-03-14 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2014-12-15 00:00:00
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journal_title:Toxicology letters
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更新日期:2003-09-15 00:00:00
abstract::Styrene-acrylonitrile trimer (SAN Trimer), a mixture of six isomers (four isomers of 4-cyano-1,2,3,4-tetrahydro-alpha-methyl-1-naphthaleneacetonitrile [THAN] and two isomers of 4-cyano-1,2,3,4-tetrahydro-1-naphthaleneproprionitrile [THNP]), is a by-product of a specific production process of styrene-acrylonitrile poly...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.01.016
更新日期:2008-04-21 00:00:00
abstract::Previous studies indicated that the enantiomers of thalidomide and its analogue EM12 exhibit differing teratogenic potencies. Unfortunately, these substances proved to be unstable and racemised considerably, so that the intrinsic teratogenic potencies of the pure enantiomers were difficult to elucidate. We have theref...
journal_title:Toxicology letters
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更新日期:1989-10-01 00:00:00
abstract::To elucidate relevance of estrogens to immune responses, we investigated whether estrogen receptor alpha (ERalpha) exists in mouse splenic B cells and T cells and the effect of 17beta-estradiol and endocrine disrupting chemicals (EDCs) on lymphocyte mitogenesis. ERalpha was identified in both male and female mouse spl...
journal_title:Toxicology letters
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更新日期:2002-07-21 00:00:00
abstract::In order to gain basic understanding in the ecotoxicity of endocrine disrupting chemicals or EDCs (including natural chemicals and some pharmaceuticals), many international research groups are currently testing these chemicals using aquatic invertebrates. This paper discusses relevant examples to address key questions...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:2002-05-10 00:00:00
abstract::Combined effects of mycotoxin mixtures are of major concern due to the widespread occurrence of human exposure to mixtures. Owing to the lack of sufficient mixture data regarding the human immune function, the aim of this study was to specify, evaluate and predict the combined effects of mycotoxin mixtures upon the fu...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2007.02.012
更新日期:2007-04-25 00:00:00
abstract::Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2009.07.029
更新日期:2009-12-01 00:00:00
abstract::The subacute nephrotoxicity of more than 20 industrial solvents has been compared in female Sprague-Dawley rats. The animals were given 5 i.p. injections of the solvents per week for 2 weeks at doses ranging from 1/20 to 1/5 of the i.p. or oral LD50 and the urinary excretion of N-acetyl-beta-D-glucosaminidase, beta 2-...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(89)90018-0
更新日期:1989-02-01 00:00:00
abstract::Women over 50 years of age in 32 cadmium(Cd)-polluted and 16 nonpolluted hamlets were studied. Itai-itai disease patients and proteinuria with glucosuria were used as indices of the effect of Cd on health. Unpolished rice samples were collected from 568 households in the same area and analyzed for Cd. The hamlet's ave...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90236-9
更新日期:1983-07-01 00:00:00
abstract::Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 mumol/kg 2,2',4,4',5,5'-hexachlorobiphenyl (HxCB). The disposition of TCDD in liver, fat, skin, spleen, lung and blood was studied at days 3, 7, 13 and 34 after dosage. H...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(95)03387-z
更新日期:1995-10-01 00:00:00