Abstract：
:Metallothionein (MT) is a low-molecular-weight and sulfur-rich protein that is induced by not only heavy metals but also physiological stresses such as fasting and restraint stresses. Although MT plays a role as a radical scavenger and a regulator of metabolism of metals, the biological function of MT induced by fasting stress has not been elucidated. In this study, we investigated the antioxidative role of MT in fasted mice. In fasted mice, the lipid peroxidation level of the liver was elevated by 24-h fasting stress, and pre-induction of hepatic MT by Zn diminished hepatic lipid peroxidation. Although 24-h fasting stress induced MT synthesis in the liver, other antioxidants such as catalase, manganese-superoxide dismutase (Mn-SOD), and glutathione peroxidase (GSHPx) were not activated in the liver. Moreover, the hepatic MT level was still elevated by fasting stress after seven cycles of repetition of alternate fasting and feeding every 24 h, but the activities of catalase, Mn-SOD and GSHPx were unchanged. These results indicate that MT induced by fasting stress plays partly as an antioxidant.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Kondoh M,Kamada K,Kuronaga M,Higashimoto M,Takiguchi M,Watanabe Y,Sato Mdoi
10.1016/s0378-4274(03)00195-4keywords:
subject
Has Abstractpub_date
2003-08-28 00:00:00pages
301-6issue
3eissn
0378-4274issn
1879-3169pii
S0378427403001954journal_volume
143pub_type
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