Acetanilide 4-hydroxylase and acetanilide 2-hydroxylase activity in hepatic microsomes from induced mice.

abstract：:The mutagenic potential of fluphenazine hydrochloride was tested on male germ cells of Drosophila melanogaster. The criterion used was sex-linked recessive lethal mutations. Oregon-K males of D. melanogaster, reared on a medium containing 0.01, 0.02 and 0.03 mg/ml of the drug, were screened for sex-linked recessive le...

journal_title：Toxicology letters

authors： Rao KP,Rao MS

更新日期：1980-12-01 00:00:00

abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...

journal_title：Toxicology letters

authors： Frith CH,Baetcke KP,Nelson CJ,Schieferstein G

更新日期：1980-12-01 00:00:00

abstract：:An in vivo micronucleus assay using Balb/C male mice was used to examine antigenotoxic effects of cimetidine (CM) on benzene (BZN) induced genotoxic effects. CM not only has therapeutic and immunomudolatory role, but it has also been shown to protect bone marrow stem cells from radiation induced clastogenic effects. T...

journal_title：Toxicology letters

authors： Mozdarani H,Kamali S

更新日期：1998-09-30 00:00:00

abstract：:The increasing industrial use of nanoparticles (NPs) has raised concerns about their impact on human health. Since aging and exposure to environmental factors are linked to the risk for developing pathologies, we address the question of TiO2 NPs toxicokinetics in the context of a realistic occupational exposure. We re...

journal_title：Toxicology letters

authors： Gaté L,Disdier C,Cosnier F,Gagnaire F,Devoy J,Saba W,Brun E,Chalansonnet M,Mabondzo A

更新日期：2017-01-04 00:00:00

abstract：:When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate of dose, ignoring uncertainties in the parameter values used in the model and their impact on model predictions. We have collected experimental data on the vari...

journal_title：Toxicology letters

authors： Gearhart JM,Mahle DA,Greene RJ,Seckel CS,Flemming CD,Fisher JW,Clewell HJ 3rd

更新日期：1993-05-01 00:00:00

abstract：:This study demonstrates an intraspecies difference in elimination of methylmercury between two genetic variant strains of mice. Following a single non-toxic dose of 203Hg labeled methylmercury (0.5 mg Hg/kg i.p.), the half-time of 203Hg elimination in the CBA/J inbred strain was 7.4 days compared to 3.0 days in the CF...

journal_title：Toxicology letters

authors： Kostyniak PJ

更新日期：1980-10-01 00:00:00

abstract：:The effect of dietary vomitoxin on the serum IgA and IgG responses to two model intestinal antigens, casein and cholera toxin (CT), were assessed in 4 experimental groups: (1) mice fed casein-based diet, (2) mice fed casein-based diet containing 25 ppm vomitoxin, (3) mice fed casein-based diet and immunized with CT, a...

journal_title：Toxicology letters

authors： Pestka JJ,Moorman MA,Warner RL

更新日期：1990-01-01 00:00:00

abstract：:Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including nerves associated with the auditory system. Based...

journal_title：Toxicology letters

authors： Wang W,Li D,Ding X,Zhao Q,Chen J,Tian K,Qiu Y,Lu L

更新日期：2017-09-05 00:00:00

abstract：:Pyrethroid pesticides are used preferably over organochlorines and organophosphates due to their high effectiveness, low toxicity to non-target organisms and easy biodegradibility. However, it is possible that during the pyrethroid metabolism, there is generation of reactive oxygen species (ROS) and pyrethroids may pr...

journal_title：Toxicology letters

authors： Kale M,Rathore N,John S,Bhatnagar D

更新日期：1999-04-12 00:00:00

abstract：:Nuclear accumulation of the tumorsuppressor protein p53 indicates the occurrence of chromatin injury (J. Cancer Res. Clin. Oncol. 1991, 117, 30; Oncogene 1993, 8, 307) and may be used as an analytical tool to detect genotoxic agents. This mechanism was used to evaluate the DNA-damaging potency (clastogenicity) of the ...

journal_title：Toxicology letters

authors： Hess RD,Brandner G

更新日期：1996-11-01 00:00:00

abstract：:The dose-dependent effects of sodium saccharin on the fertility and the induction of chromosomal translocations in treated mice and their F1 males were examined. C3H X 101 mice were treated with saccharin for 2 successive weeks at doses of 200 and 500 mg/kg of body wt. Data from the fertility study showed that sacchar...

journal_title：Toxicology letters

authors： Pecevski J,Vuksanović L,Savković N,Alavantić D,Radivojević D

更新日期：1983-12-01 00:00:00

abstract：:Pyrroloquinoline quinone (PQQ), a redox cofactor in the mitochondrial respiratory chain, has proven to protect neurons against glutamate-induced damage both in vitro and in vivo. This study was aimed to investigate the possible neuroprotective effects of PQQ in rotenone-induced Parkinson's disease (PD) model. Pre-trea...

journal_title：Toxicology letters

authors： Qin J,Wu M,Yu S,Gao X,Zhang J,Dong X,Ji J,Zhang Y,Zhou L,Zhang Q,Ding F

更新日期：2015-11-04 00:00:00

abstract：:We have recently demonstrated that the antibody response to the T-cell-dependent antigen, sheep red blood cells (SRBCs), was suppressed by ethyl carbamate in female BALB/c mice. At the same doses, ethyl carbamate decreased in the numbers of splenic macrophages, B cells, total T cells, CD4(+) T cells and CD8(+) T cells...

journal_title：Toxicology letters

authors： Cha SW,Lee HJ,Cho MH,Lee MH,Koh WS,Han S,Kim J,Lee E,Nam D,Jeong TC

更新日期：2001-03-08 00:00:00

abstract：:Various hypotheses on the origin of cancer stem cells (CSCs) exist, including that CSCs develop from transformed human bone marrow mesenchymal stem cells (hBMSC). Since the polyether antibiotic salinomycin selectively kills CSCs, the present study aims to elucidate the effects of salinomycin on normal hBMSC. The immun...

journal_title：Toxicology letters

authors： Scherzed A,Hackenberg S,Froelich K,Rak K,Technau A,Radeloff A,Nöth U,Koehler C,Hagen R,Kleinsasser N

更新日期：2013-04-26 00:00:00

abstract：:Explants from first-trimester placentae obtained from non-smoking women were incubated with doses of 0, 0.75, 1.5, 3, 6 and 12 micrograms of cadmium (Cd) as CdCl2 for 6 or 24 h. At the end of the incubation period, the activities of placental aryl hydrocarbon hydroxylase (AHH) (a phase I enzyme), quinone reductase (QR...

journal_title：Toxicology letters

authors： Boadi WY,Urbach J,Brandes JM,Yannai S

更新日期：1992-04-01 00:00:00

abstract：:Paracetamol (acetaminophen, APAP) is the most frequently used analgesic drug worldwide. However, patients in several specific populations can have an increased exposure to toxic APAP metabolites. Therefore, APAP-protein adducts have been proposed as an alternative marker for the assessment of APAP intoxications and as...

journal_title：Toxicology letters

authors： Delahaye L,Dhont E,De Cock P,De Paepe P,Stove CP

更新日期：2020-05-15 00:00:00

abstract：:Effects of sublethal concentration (0.8 of LC50 96 h) of nickel sulphate (NiSO4 X 7H2O) on muscle glycogen and blood lactic acid levels of a freshwater teleost, Colisa fasciatus, at time intervals from 3-96 h have been recorded. Muscle glycogen levels showed a general decrease at all time intervals compared with contr...

journal_title：Toxicology letters

authors： Chaudhry HS

更新日期：1984-01-01 00:00:00

abstract：:Computer simulation can be used to integrate existing toxicity information within a biologically realistic framework. Simulation models calculate relevant measures of target tissue dose based on physiological, biochemical and physicochemical properties and readily support the dose, route, species and interchemical ext...

journal_title：Toxicology letters

authors： Clewell HJ 3rd,Andersen ME

更新日期：1989-12-01 00:00:00

abstract：:A physiologically based pharmacokinetic (PBPK) model describing the disposition of 2-butoxyethanol (2-BE) was developed in order to predict the urinary concentration of its major metabolite, butoxyacetic acid (BAA) under a range of exposure scenarios. Based on Corley et al. [Corley, R.A., Bormett, G.A., Ghanayem, B.I....

journal_title：Toxicology letters

authors： Franks SJ,Spendiff MK,Cocker J,Loizou GD

更新日期：2006-04-10 00:00:00

abstract：:Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, expe...

journal_title：Toxicology letters

authors： Lauková M,Pervez S,Rosman R,Velíšková J,Velíšek L,Shakarjian MP

更新日期：2019-06-15 00:00:00

abstract：OBJECTIVE:Ethanol intake can increase the sedative effects of gamma-hydroxybutyrate/gamma-butyrolactone (GHB/GBL), although the real clinical impact is unknown. We studied the clinical impact of the co-ingestion of ethanol in patients presenting to the Emergency Department (ED) with acute toxicity related to GHB/GBL us...

journal_title：Toxicology letters

authors： Galicia M,Dargan PI,Dines AM,Yates C,Heyerdahl F,Hovda KE,Giraudon I,Euro-DEN Plus Research Group.,Wood DM,Miró Ò,Euro-DEN Plus Research Group.

更新日期：2019-10-10 00:00:00

abstract：:The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseas...

journal_title：Toxicology letters

authors： Luster MI,Simeonova PP,Gallucci RM,Bruccoleri A,Blazka ME,Yucesoy B

更新日期：2001-03-31 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to identify pathways involved in pneumoconiosis susceptibility, clarify their potential mechanisms, and generate SNP-to-gene to pathway hypotheses using an analytical pathway-based approach. METHODS:The identify candidate causal SNPs and pathways (ICSNPathway) was used to pe...

journal_title：Toxicology letters

authors： Wang T,Yang J,Ji X,Chu M,Zhang R,Dai J,Jin G,Hu Z,Shen H,Ni C

更新日期：2015-01-05 00:00:00

abstract：:Breathing pattern and lung mechanical parameters were measured in 7 female Wistar rats (ca. 200 g) during exposure to 1.0 (n = 5) or 1.3 (n = 2) ppm ozone in air for 2 h and during a 2-h post-exposure observation period. Changes in breathing pattern showed a gradual decrease from 3 to 2 Hz at constant minute ventilati...

journal_title：Toxicology letters

authors： Zwart A,Arts JH

更新日期：1994-06-01 00:00:00

abstract：:The widespread use of insecticides has amounted to a large scale 'experiment' in natural selection of insects by chemicals of toxicological importance to humans. Specific examples in which the molecular basis of insecticide resistance has been studied in detail are presented here. The biochemical/physiological mechani...

journal_title：Toxicology letters

authors： Feyereisen R

更新日期：1995-12-01 00:00:00

abstract：:There is experimental and epidemiological evidence demonstrating that polycyclic aromatic hydrocarbons (PAHs) are involved in the pathogenesis of cardiovascular diseases. However, heterocyclic amines (HAs), a class of carcinogenic compounds present in food, which share many biochemical features with PAHs, have not rec...

journal_title：Toxicology letters

authors： Lopez-Mendez C,Bermudez-Fajardo A,Ioannides C,Oviedo-Orta E

更新日期：2009-03-10 00:00:00

abstract：:Nickel is a metal widely employed in dental alloys, and due to peculiar properties of certain nickel-based materials, it cannot be substituted with other metals in some applications. The release of nickel ions from dental alloys placed into long-term contact with mouth soft tissues is alarming because of the toxic, im...

journal_title：Toxicology letters

authors： Trombetta D,Mondello MR,Cimino F,Cristani M,Pergolizzi S,Saija A

更新日期：2005-12-15 00:00:00

abstract：:1,3,5-Trinitro-2-acetyl pyrrole (TNAP) is a product derived from the reaction of 2-acetyl pyrrole with nitrite in the model of Maillard browning systems. This compound is moderately mutagenic to the Salmonella strains TA98 and TA100 and is markedly cytotoxic to mouse C3H10T1/2 cells. Experiments are performed to inves...

journal_title：Toxicology letters

authors： Lin YL,Tseng TH,Hsu JD,Chu CY,Wang CJ

更新日期：1996-12-16 00:00:00

abstract：:A concern among hospital personnel is their exposure to mutagenic drugs and in the incidental exposures that could occur in caring for the patients. In a recent published study the mutagenicity of urine from patients administered antineoplastic drugs was determined and techniques were developed to chemically inactivat...

journal_title：Toxicology letters

authors： Monteith DK,Connor TH,Benvenuto JA,Fairchild EJ,Theiss JC

更新日期：1988-03-01 00:00:00

abstract：:The effect of zinc (Zn) administration on the uptake and retention of cadmium (Cd), copper (Cu) and Zn in liver, kidneys and testes of cadmium exposed rats was investigated. Exposure to Cd caused a significant increase in the uptake of these metals in the 3 organs. The administration of Zn after the Cd exposure had li...

journal_title：Toxicology letters

authors： Behari JR,Tandon SK

更新日期：1980-02-01 00:00:00