Evaluation of the antigenicity of hydrolyzed cow's milk protein formulas using the mouse basophil activation test.

abstract：:The anesthetic potencies of n-alcohols increase progressively with lengthening of the carbon chain and then disappear at a cut-off point of a longer-chain n-alcohol. In order to assess the mechanisms for cut-off in mammalian central nervous system, the effects of a series of n-alcohols (C(2)-C(11)) were examined on th...

journal_title：Toxicology letters

authors： Takehana K,Hirota K,Roth SH,Masuda A,Ito Y

更新日期：2000-05-19 00:00:00

abstract：:The grazing trial at Kidston Gold Mine, North Queensland, was aimed specifically to assess the uptake of metals from the tailing and the potential for unacceptable contamination of saleable meat. Further aims included estimating metal dose rates and identifying potential exposure pathways including plant uptake of hea...

journal_title：Toxicology letters

authors： Bruce SL,Noller BN,Grigg AH,Mullen BF,Mulligan DR,Ritchie PJ,Currey N,Ng JC

更新日期：2003-01-31 00:00:00

abstract：:Sensitivity to chemicals is a toxicological concept, contained in the dose-response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a ...

journal_title：Toxicology letters

authors： Winder C

更新日期：2002-03-10 00:00:00

abstract：:Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...

journal_title：Toxicology letters

authors： Yuan L,Mu P,Huang B,Li H,Mu H,Deng Y

更新日期：2018-12-15 00:00:00

abstract：:Troglitazone (TGZ) is an orally active hypoglycemic agent which is used for the treatment of non-insulin-dependent diabetes mellitus. It had been associated with severe drug-induced liver failure which resulted in its withdrawal from the market in 2000. While the exact mechanism of its toxicity remains unknown, it has...

journal_title：Toxicology letters

authors： Saha S,New LS,Ho HK,Chui WK,Chan EC

更新日期：2010-02-01 00:00:00

abstract：:In the field of aquatic toxicology, quantitative structure-activity relationships (QSARs) have developed as scientifically credible tools for predicting the toxicity of chemicals when little or no empirical data are available. A fundamental understanding of toxicological principles has been considered an important com...

journal_title：Toxicology letters

authors： Bradbury SP

更新日期：1995-09-01 00:00:00

abstract：:This paper compares two methods for global optimization of physiologically based toxicokinetic models: Monte Carlo optimization, which searches randomly for the optimum; and the simplex method, which updates systematically an array of parameter values. Two measures of goodness-of-fit are also contrasted: criterion fun...

journal_title：Toxicology letters

authors： Woodruff TJ,Bois FY

更新日期：1993-08-01 00:00:00

abstract：:Benzo(a)pyrene (BP) is the best studied polycyclic aromatic hydrocarbon, classified as carcinogenic to humans. The carcinogenic metabolite, benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), binds covalently to DNA. The key enzyme in this metabolic reaction is CYP1A1, which has also been found in placenta and human t...

journal_title：Toxicology letters

authors： Karttunen V,Myllynen P,Prochazka G,Pelkonen O,Segerbäck D,Vähäkangas K

更新日期：2010-08-16 00:00:00

abstract：:The mutagenicity of four chemical compounds to strain TA100 of S. typhimurium was affected differently by liver S-9 preparations from untreated Sprague-Dawley rats and from rainbow trout (Salmogairdneri). These two species were equally effective in decreasing the direct mutagenicity of sodium dichromate. Rat preparati...

journal_title：Toxicology letters

authors： de Flora S,Zanacchi P,Bennicelli C,Arillo A

更新日期：1982-03-01 00:00:00

abstract：:The genotoxicity of polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs may be influenced by the interaction of the compounds. In this study, our data showed that benzo[a]pyrene (BaP)-DNA adduct levels were decreased in a dose-dependent manner when the human hepatoma cell line HepG2 simultaneously treated with B...

journal_title：Toxicology letters

authors： Cherng SH,Hsu SL,Yang JL,Yu CT,Lee H

更新日期：2006-03-01 00:00:00

abstract：:Cigarette smoke (CS) induced chronic obstructive pulmonary disease (COPD) has been emerging as a great health problem in China. However, lack of appropriate animal model slows down the progress in understanding pathogenesis of the disease. The aim of current study is to establish and evaluate a more adequate rat model...

journal_title：Toxicology letters

authors： Zheng H,Liu Y,Huang T,Fang Z,Li G,He S

更新日期：2009-09-28 00:00:00

abstract：:Isolated rat hepatocytes incubated aerobically formed measurable amounts of ethane, a parameter for lipid peroxidation. This ethane formation increased several-fold due to carbon tetrachloride (CCl4) depending on its concentration. Cell damage as measured by trypan blue uptake and lactate dehydrogenase release poorly ...

journal_title：Toxicology letters

authors： de Ruiter N,Ottenwälder H,Muliawan H,Kappus H

更新日期：1981-06-01 00:00:00

abstract：:The environmental neurotoxin β-N-methylamino-L-alanine (BMAA) is not an amino acid that is normally found in proteins. Our previous autoradiographic study of (3)H-labeled BMAA in adult mice unexpectedly revealed a tissue distribution similar to that of protein amino acids. The aim of this study was to characterize the...

journal_title：Toxicology letters

authors： Karlsson O,Jiang L,Andersson M,Ilag LL,Brittebo EB

更新日期：2014-04-07 00:00:00

abstract：:A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...

journal_title：Toxicology letters

authors： Okey AB,Riddick DS,Harper PA

更新日期：1994-01-01 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (cisplatin) is one of the most effective antitumor agents currently available for cancer chemotherapy. Unfortunately, its clinical use is severely limited by its dose-dependent nephrotoxicity. Recently, it has been reported that this nephrotoxicity is associated with an increase in lip...

journal_title：Toxicology letters

authors： Sadzuka Y,Shoji T,Takino Y

更新日期：1991-07-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a DNA-binding protein that is abundantly expressed in most tissues. Recently, HMGB1 has gained much attention for its regulation of immunity and inflammation. Yet its role in toluene diisocyanate (TDI)-induced asthma still remains poorly characterized. In this study, mice were sens...

journal_title：Toxicology letters

authors： Yao L,Zhao H,Tang H,Song J,Dong H,Zou F,Cai S

更新日期：2015-11-19 00:00:00

abstract：:Various hypotheses on the origin of cancer stem cells (CSCs) exist, including that CSCs develop from transformed human bone marrow mesenchymal stem cells (hBMSC). Since the polyether antibiotic salinomycin selectively kills CSCs, the present study aims to elucidate the effects of salinomycin on normal hBMSC. The immun...

journal_title：Toxicology letters

authors： Scherzed A,Hackenberg S,Froelich K,Rak K,Technau A,Radeloff A,Nöth U,Koehler C,Hagen R,Kleinsasser N

更新日期：2013-04-26 00:00:00

abstract：:Benzene is a common occupational hazard and a ubiquitous environmental pollutant. Benzene exposure at the levels even below 1ppm still showed hematotoxicity. It is widely accepted that the metabolites of benzene play important roles in the benzene toxicity to the hematopoietic system, but little is known about the eff...

journal_title：Toxicology letters

authors： Wu XR,Xue M,Li XF,Wang Y,Wang J,Han QL,Yi ZC

更新日期：2011-06-24 00:00:00

abstract：:Even though compounds of nickel, arsenic, cobalt and cadmium are carcinogenic, their mutagenic potentials are rather weak. In contrast, they exert pronounced comutagenic effects, which may be explained by disturbances of different DNA repair systems. Thus, cobalt, arsenic, nickel and cadmium interfere with base and nu...

journal_title：Toxicology letters

authors： Hartwig A,Schwerdtle T

更新日期：2002-02-28 00:00:00

abstract：:Administration of the chemical carcinogen 2-acetylaminofluorene (2-AAF) has previously been shown to lower hepatic epidermal growth factor (EGF) binding levels during chemically induced hepatocarcinogenesis. To further characterize the specificity of this response, EGF binding levels for liver microsomes were determin...

journal_title：Toxicology letters

authors： Ringer DP,Panzeter PL,DeCicco LA

更新日期：1997-03-14 00:00:00

abstract：:Mercury, one of the widespread pollutants in the world, induces oxidative stress and dysfunction in many cell types. Alveolar type II epithelial cells are known to be vulnerable to oxidative stress. Alveolar type II epithelial cells produce and secrete surfactants to maintain morphological organization, biophysical fu...

journal_title：Toxicology letters

authors： Lu TH,Chen CH,Lee MJ,Ho TJ,Leung YM,Hung DZ,Yen CC,He TY,Chen YW

更新日期：2010-05-04 00:00:00

abstract：:The separation and determination of 3-nitropropionic acid (NPA) in bovine urine by reverse-phase HPLC is described. The method utilizes a rapid ethyl acetate extraction and this clean-up step also improves the chromatographic resolution of NPA in bovine plasma. A simple colorimetric method is also developed for the ra...

journal_title：Toxicology letters

authors： Majak W,McDiarmid RE

更新日期：1990-02-01 00:00:00

abstract：:The acute toxicity of organothiophosphate insecticides like parathion results from their metabolic activation by cytochromes P450. The present study is directed towards the characterization of cytochrome-P450-dependent metabolism of parathion by various mouse brain regions. Intraperitoneal administration of [35S]parat...

journal_title：Toxicology letters

authors： Soranno TM,Sultatos LG

更新日期：1992-01-01 00:00:00

abstract：:Occupational and environmental exposure to pesticides has been associated with thyroid dysfunction, particularly changes in circulating thyroid hormone levels (T3, T4) and thyroid stimulating hormone (TSH). This study assessed the association between environmental exposure to pesticides and the risk of developing thyr...

journal_title：Toxicology letters

authors： Requena M,López-Villén A,Hernández AF,Parrón T,Navarro Á,Alarcón R

更新日期：2019-10-15 00:00:00

abstract：:Paraquat poisoning results in damages of multiple organs including liver, kidney and lung, and antioxidants have been proven to have protective effects. As a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), was introduced to clinical use recently, its protective effect was studied on acute ...

journal_title：Toxicology letters

authors： Saibara T,Toda K,Wakatsuki A,Ogawa Y,Ono M,Onishi S

更新日期：2003-06-05 00:00:00

abstract：:Impairment in cholinergic systems is a highly consistent finding in human dementia. Among cholinergic markers, marked decreases in nicotine binding have been most consistently observed in the telencephalic regions of demented patients and are thought to contribute to the cognitive deficits associated with ageing and a...

journal_title：Toxicology letters

authors： Zanardi A,Leo G,Biagini G,Zoli M

更新日期：2002-02-28 00:00:00

abstract：:We recently showed in a rat model of dichromate-induced acute renal failure (ARF) that the elimination but not the distribution of pralidoxime was altered resulting in sustained plasma pralidoxime concentrations. The aim of this study was to compare the efficiency of pralidoxime in normal and acute renal failure rats ...

journal_title：Toxicology letters

authors： Kayouka M,Houzé P,Debray M,Baud FJ

更新日期：2009-08-25 00:00:00

abstract：:Recently published studies suggest a weak positive correlation between increased dietary acrylamide intake and the increased risk of endometrial and ovarian cancer. However, risk assessment of acrylamide remains difficult because the carcinogenic mechanisms are still unknown and in particular the molecular effects of ...

journal_title：Toxicology letters

authors： Ehlers A,Lenze D,Broll H,Zagon J,Hummel M,Lampen A

更新日期：2013-02-27 00:00:00

abstract：:Melamine (MA) exposure causes male reproductive toxicity, however, the mechanism remains unclear. In this study, we investigated the roles of the blood-testis barrier (BTB) in MA-induced reproductive toxicity in piglets. Male weaned piglets were exposed to MA concentrations of 0, 100, 300, and 1000 mg/kg in the diet f...

journal_title：Toxicology letters

authors： Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

更新日期：2018-10-15 00:00:00

abstract：:We investigated the effect of copper on cadmium-induced cytotoxicity on vascular endothelial cells from bovine aorta in a culture system. Cytotoxicity was evaluated by the [3H]adenine release assay and the histological observation. After a 24-h incubation, cadmium exhibited a significant cytotoxicity on confluent cult...

journal_title：Toxicology letters

authors： Kaji T,Fujiwara Y,Koyanagi E,Yamamoto C,Mishima A,Sakamoto M,Kozuka H

更新日期：1992-10-01 00:00:00