Abstract:
:Induction of endotoxin tolerance in rats led to reductions in bile flow and BSP excretion. BSP serum retention or storage of BSP in the liver was not affected. Although serum alanine aminotransferase (ALT) activity was slightly elevated in endotoxin-tolerant rats, the levels of serum aspartate amino-transferase (AST) and hepatic 5'-nucleotidase were normal. These in vivo data support the validity of in vitro studies demonstrating the cholestatic effect of endotoxin and the viewpoint that endotoxin may be responsible for the cholestatic jaundice associated with Gram-negative bacterial infections.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Boelsterli UA,Abernathy CO,Balazs T,Zimmerman HJdoi
10.1016/0378-4274(82)90151-5subject
Has Abstractpub_date
1982-05-01 00:00:00pages
207-12issue
3-4eissn
0378-4274issn
1879-3169pii
0378-4274(82)90151-5journal_volume
11pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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