Abstract:
:In male Sprague-Dawley rats, motor and sensory conduction velocities (MNCV and SNCV) of the tail nerve decreased significantly as a result of oral administration of 400 and 200 mg/kg of 2,5 hexanedione (2,5-HD) once daily, 5 days a week for up to 7 and 15 weeks, respectively; and of whole-body exposure to 300 ppm of vinyltoluene for 6 h daily, 5 days a week for up to 21 weeks. Exposure to 100 ppm of vinyltoluene did not cause any significant impairment of tail nerve function throughout the 21-week exposure period. Significant changes in MNCV and SNCV were consistently observed from weeks 4 and 2, respectively, in 2,5-HD-treated rats. Changes resulting from exposure to 300 ppm of vinyltoluene were reported intermittently from week 15. Significant linear relationships were established between the length of treatment with 2,5-HD, length of exposure to 300 ppm of vinyltoluene, and the extent of impairment of tail nerve function. Structural damage to the sciatic nerves was only seen in 2,5-HD-treated rats. It is concluded that vinyltoluene can be regarded as an airborne chemical which leads to the development of a borderline experimental neuropathy at a level of 300 ppm.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Gagnaire F,Nicot T,Zissu D,Bonnet P,de Ceaurriz Jdoi
10.1016/0378-4274(86)90175-xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
27-34issue
1eissn
0378-4274issn
1879-3169pii
0378-4274(86)90175-Xjournal_volume
30pub_type
杂志文章abstract::Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or ...
journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2011.04.032
更新日期:2011-07-28 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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abstract::L-Carnitine is a critical metabolite indispensable for the metabolism of lipids as it facilitates fatty acid transport into the mitochondrion where β-oxidation occurs. Human astrocytes (CCF-STTG1 cells) and hepatocytes (HepG2 cells) exposed to aluminum (Al) and hydrogen peroxide (H₂O₂), were characterized with lower l...
journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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更新日期:2003-09-30 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90085-x
更新日期:1994-12-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2016-11-16 00:00:00
abstract::Impairments induced by sublethal doses of two pesticides Carbaryl and Endosulfan have been studied on the ovaries of a freshwater teleost Channa striatus by exposing the fish for a period of 2 to 30 days during the spawning season. The pesticide exposure produced reduction in the number of oocytes, reduction in size a...
journal_title:Toxicology letters
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更新日期:1984-01-01 00:00:00
abstract::Toxic industrial chemicals are used throughout the world to produce everyday products such as household and commercial cleaners, disinfectants, pesticides, pharmaceuticals, plastics, paper, and fertilizers. These chemicals are produced, stored, and transported in large quantities, which poses a threat to the local civ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.10.010
更新日期:2016-02-26 00:00:00
abstract::Benzene is a human leukemogen, and a bone marrow toxin and carcinogen in experimental animals. The reactive intermediates involved in benzene toxicity and their mechanism(s) of action have not been clearly delineated. We have investigated the clastogenic and cytotoxic effects of trans,trans-muconaldehyde (MUC), a reac...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2001-05-19 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.06.009
更新日期:2015-09-02 00:00:00
abstract::The hedgehog (HH) signaling pathway plays an important role in lung development, but its significance in silicosis is unclear. We showed that in human coal pneumoconiosis autopsy specimens, Sonic Hedgehog (SHH) and the Glioma-associated oncogene homolog transcription factors family (GLI) 1 proteins were up-regulated, ...
journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2019.05.023
更新日期:2019-10-01 00:00:00
abstract::Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it can interfere with steroid biosynthesis and metabolism. However, the mechanism is unclear. The objective of the present study is to investigate the effects of BPA on two isoforms of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and 11β-HSD2)...
journal_title:Toxicology letters
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更新日期:2012-11-30 00:00:00
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journal_title:Toxicology letters
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.toxlet.2003.07.004
更新日期:2004-04-15 00:00:00
abstract::Octamethylcyclotetrasiloxane (D4) is a low-molecular-weight volatile cyclic siloxane, primarily used as an intermediate in the production of some widely-used industrial and consumer silicone based polymers and may be present as a component in a variety of consumer products. A global "harmonized" risk assessment was co...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.05.019
更新日期:2017-10-20 00:00:00
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2009.10.014
更新日期:2010-02-01 00:00:00
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journal_title:Toxicology letters
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doi:10.1016/j.toxlet.2015.04.012
更新日期:2015-06-15 00:00:00
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更新日期:2018-09-01 00:00:00
abstract::Monosodium glutamate (MSG) was administered to adult male mice for 6 d at dose levels of 2, 4 and 8 mg/g b.w. Dose levels of 4 and 8 mg/g MSG resulted in significant changes in serum total lipids, triglycerides, phospholipids, free fatty acids and blood glucose 31 d after cessation of exposure. Administration of 2 mg/...
journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1989-02-01 00:00:00
abstract::The risk of lung and urinary bladder cancers was reported to be increased in individuals who carried high risk genotypes in either cytochrome P450 (CYP)1A1, CYP2E1 or glutathione S-transferase (GST)M1, and the combined genotype of both CYP1A1 and GSTM1 enzymes have an enhanced tendency of risk to lung cancer more sign...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:1998-12-28 00:00:00
abstract:BACKGROUND:GAPDH, well known for its house-keeping functions, has also been shown to be involved in cell injury, apoptosis and death under conditions of stress such as starvation, chemical injury and oxidative stress. This study examines the effect of GAPDH knockdown on cell injury in response to Rotenone. METHODS:GAP...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.02.017
更新日期:2015-05-05 00:00:00
abstract::Pyrethroid pesticides are used preferably over organochlorines and organophosphates due to their high effectiveness, low toxicity to non-target organisms and easy biodegradibility. However, it is possible that during the pyrethroid metabolism, there is generation of reactive oxygen species (ROS) and pyrethroids may pr...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(98)00399-3
更新日期:1999-04-12 00:00:00
abstract::Nitrogen mustard (HN-2), also known as mechlorethamine, is an alkylating anticancer agent as well as blister inducing chemical warfare agent. We evaluated the cytoprotective efficacy of amifostine, DRDE-07 and their analogues, and other antidotes of mustard agents against HN-2. Administration of 1 LD(50) of HN-2 (20mg...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2009.04.015
更新日期:2009-08-10 00:00:00
abstract::A previous study revealed that a single i.p. administration of 6 mg/kg body wt. of mercuric chloride (MC) durably inhibits the rat cerebral microvascular Na+/K(+)-ATPase activity [1]. In this study, cerebral microvessels isolated 18 h after MC treatment were compared to those obtained from control rats and subsequentl...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90127-9
更新日期:1994-02-15 00:00:00
abstract::Histone deacetylase (HDAC) inhibitors have recently emerged as a new class of anti-cancer agents. Trichostatin A (TSA), a classical HDAC inhibitor, has been demonstrated to induce cell cycle arrest, promote cell apoptosis, and inhibit metastasis. However, the molecular mechanism underlying TSA function has not been fu...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2013.05.643
更新日期:2013-07-31 00:00:00
abstract::Recently published studies suggest a weak positive correlation between increased dietary acrylamide intake and the increased risk of endometrial and ovarian cancer. However, risk assessment of acrylamide remains difficult because the carcinogenic mechanisms are still unknown and in particular the molecular effects of ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2012.12.017
更新日期:2013-02-27 00:00:00
abstract::Betel quid chewing, which contributes high concentration of safrole in saliva, is a popular oral habit in Taiwan. Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known. Here, we used LC/ESI-ITMS(n) and LC/QTOF-MS confirmed safrole-dGMP as reference standard to dete...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.09.013
更新日期:2008-12-15 00:00:00