Effect of vitamin C on acute paracetamol poisoning.

abstract：:For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activ...

journal_title：Toxicology letters

authors： Matsukura M,Koike K,Zon G

更新日期：1995-12-01 00:00:00

abstract：:Due to advances in nanotechnology, exposure to particle compounds in the workplace has become unavoidable. Assessment of their toxicity on health is an important occupational safety issue. This study was conducted in mice to investigate the toxicological effects of submicron and nano-iron oxide particles on pulmonary ...

journal_title：Toxicology letters

authors： Ban M,Langonné I,Huguet N,Goutet M

更新日期：2012-05-05 00:00:00

abstract：:Testicular Leydig cells express estrogen receptors and are the predominant source of the male sex steroid hormone testosterone (T). Previous studies demonstrated that genistein acts through estrogen receptors in Leydig cells. In the present study, pre-treatment of Leydig cells isolated from 35 day-old male Long Evans ...

journal_title：Toxicology letters

authors： Hancock KD,Coleman ES,Tao YX,Morrison EE,Braden TD,Kemppainen BW,Akingbemi BT

更新日期：2009-02-10 00:00:00

abstract：:Mycotoxins and heavy metals are ubiquitous in the environment and contaminate many foods. The widespread use of pesticides in crop production to control disease contributes further to the chemical contamination of foods. Thus multiple chemical contaminants threaten the safety of many food commodities; hence the presen...

journal_title：Toxicology letters

authors： Clarke R,Connolly L,Frizzell C,Elliott CT

更新日期：2015-10-01 00:00:00

abstract：:Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors dist...

journal_title：Toxicology letters

authors： Mou Z,Yuan YH,Zhang Z,Song LK,Chen NH

更新日期：2020-05-15 00:00:00

abstract：:Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens. Studies on the mode-of-action of arsenite indicate that it can also act as co-carcinogen or as a cancer promoter, and that it can facilitate progression of cancers. Some studies on development of lung cancers have suggested a synergism between arsenit...

journal_title：Toxicology letters

authors： Pang Y,Xu Y,Li H,Li Y,Zhao Y,Jiang R,Shen L,Zhou J,Wang X,Liu Q

更新日期：2013-04-12 00:00:00

abstract：:Hexachlorobenzene (HCB) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) kinetics were compared in rats before, during and after partial starvation. Food restriction produced a drastic mobilization of the residues stored in the adipose tissue resulting in symptoms of neurotoxicity. The redistribution was reversibl...

journal_title：Toxicology letters

authors： To-Figueras J,Gómez-Catalán J,Rodamilans M,Corbella J

更新日期：1988-07-01 00:00:00

abstract：:Cadmium is a toxic heavy metal which has been shown to be a possible risk factor of atherosclerosis in epidemiological and experimental studies. Since intimal hyperplasia in vascular tissue is an important component of atherosclerosis, we examined the effect of cadmium on the proliferation of vascular smooth muscle ce...

journal_title：Toxicology letters

authors： Fujiwara Y,Watanabe S,Kaji T

更新日期：1998-02-01 00:00:00

abstract：:Biochemical and histopathologic parameters of nephrotoxicity were measured in groups of male Fischer-344 rats after a 2-week, 5-days-a-week schedule of oral administration (0.5 ml/kg) of the following substances: aviation gasoline (grade 100) (AVG), automobile regular unleaded gasoline (ULG) and 2,2,4-trimethylpentane...

journal_title：Toxicology letters

authors： Gérin M,Viau C,Talbot D,Greselin E

更新日期：1988-11-01 00:00:00

abstract：:Troglitazone (TGZ) is an orally active hypoglycemic agent which is used for the treatment of non-insulin-dependent diabetes mellitus. It had been associated with severe drug-induced liver failure which resulted in its withdrawal from the market in 2000. While the exact mechanism of its toxicity remains unknown, it has...

journal_title：Toxicology letters

authors： Saha S,New LS,Ho HK,Chui WK,Chan EC

更新日期：2010-02-01 00:00:00

abstract：:The relative toxicity of three legacy and six emerging brominated flame retardants* was studied in the male Harlan Sprague Dawley rat. The hepatocellular and thyroid toxicity of each flame retardant was evaluated following five-day exposure to each of the nine flame retardants (oral gavage in corn oil) at 0.1-1000 μmo...

journal_title：Toxicology letters

authors： Shockley KR,Cora MC,Malarkey DE,Jackson-Humbles D,Vallant M,Collins BJ,Mutlu E,Robinson VG,Waidyanatha S,Zmarowski A,Machesky N,Richey J,Harbo S,Cheng E,Patton K,Sparrow B,Dunnick JK

更新日期：2020-10-10 00:00:00

abstract：OBJECTIVES:Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Maximal oxime effects are expected when effective doses are administered as soon as possible and as long as reactivation can be anticipated. An obidoxime plasma level i...

journal_title：Toxicology letters

authors： Thiermann H,Eyer F,Felgenhauer N,Pfab R,Zilker T,Eyer P,Worek F

更新日期：2010-09-01 00:00:00

abstract：:Nuclear accumulation of the tumorsuppressor protein p53 indicates the occurrence of chromatin injury (J. Cancer Res. Clin. Oncol. 1991, 117, 30; Oncogene 1993, 8, 307) and may be used as an analytical tool to detect genotoxic agents. This mechanism was used to evaluate the DNA-damaging potency (clastogenicity) of the ...

journal_title：Toxicology letters

authors： Hess RD,Brandner G

更新日期：1996-11-01 00:00:00

abstract：:The effects of cadmium (Cd) on the immune organs were examined histopathologically. On 2 or 3 days after a single i.p. injection of 1.8 mg Cd/kg body weight into mice, slight loss of body weight, significant decrease of thymus weight and marked increase of spleen weight were observed. Lymph node weight did not show an...

journal_title：Toxicology letters

authors： Yamada YK,Shimizu F,Kawamura R,Kubota K

更新日期：1981-04-01 00:00:00

abstract：:Chemical warfare agents, such as soman, and pesticides, such as chlorpyrifos, dichlorvos or malathion, are toxic organophosphorous compounds (OPCs) that are readily absorbed by the skin. Decontamination using solvents or surfactants may modify the cornified layer - the skin's main barrier against xenobiotic penetratio...

journal_title：Toxicology letters

authors： Mircioiu C,Voicu VA,Ionescu M,Miron DS,Radulescu FS,Nicolescu AC

更新日期：2013-05-23 00:00:00

abstract：UNLABELLED:The Mre11, Rad50, and Nbs1 (MRN) complex is a DNA double-strand break sensor involved in DNA damage repair. Herein, we explored whether deletion of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoprotective gene, affected MRN complex expression in the kidney after cisplatin-induced acute kidney injury (AKI)....

journal_title：Toxicology letters

authors： Kim YJ,Kim TW,Park SR,Kim HT,Jung DY,Ryu SY,Jung JY

更新日期：2016-01-22 00:00:00

abstract：:Sulfolane is a solvent which produces hypothermia and decreased oxygen consumption following acute exposure. In the present experiment, we investigated effects of sulfolane on a behavioral measure of toxicity at ambient temperatures which would either prevent or facilitate the development of hypothermia. Adult male Lo...

journal_title：Toxicology letters

authors： Ruppert PH,Dyer RS

更新日期：1985-11-01 00:00:00

abstract：:In this study, we aimed to evaluate the genotoxic effects of fungicides fenarimol and propamocarb which are used to protect crops from fungi. For this reason, bone-marrow micronucleus and chromosome aberration tests were carried out in Swiss albino mice. Mice were injected with four different doses of fenarimol and pr...

journal_title：Toxicology letters

authors： Aydemir N,Bilaloğlu R

更新日期：2004-02-28 00:00:00

abstract：:Cadmium (Cd), which accumulates primarily in the liver and the kidney, induces apoptosis and also causes necrotic cell death in certain pathophysiologic situations. Previously, we have shown that Cd activated mitogen-activated protein kinases and that sulfur amino acid deficiency potentiated Cd-induced cytotoxicity vi...

journal_title：Toxicology letters

authors： Kim SC,Cho MK,Kim SG

更新日期：2003-10-15 00:00:00

abstract：:Polarographic measurements of the rates of oxygen consumption by isolated rat liver mitochondria respiring on pyruvate/malate in metabolic state 4 revealed that additions of micromolar amounts of chalepin, a naturally occurring furocoumarin resulted in significant decreases in respiratory rates. At 16 microM chalepin,...

journal_title：Toxicology letters

authors： Olorunsogo OO,Emerole GO,Malomo SO,Thabrew MI

更新日期：1983-03-01 00:00:00

abstract：:It is well known that dichlorodiphenyltrichloroethane (DDT) is used as an insecticide and prevents many people in the tropical zone from devastating malaria. On the other hand, a number of reports have indicated that it may act as an endocrine disruptor and also has possible carcinogenic effects. However, the effects ...

journal_title：Toxicology letters

authors： Shinomiya N,Shinomiya M

更新日期：2003-02-03 00:00:00

abstract：:E-64d (a calpain and autophagy inhibitor) has previously been shown safe for the treatment of Alzheimer's disease in humans. In the present study, the potential protective mechanism of E-64d on hippocampal aberrant mossy fiber sprouting was examined in a developmental rat model of penicillin-induced recurrent epilepti...

journal_title：Toxicology letters

authors： Ni H,Ren SY,Zhang LL,Sun Q,Tian T,Feng X

更新日期：2013-02-27 00:00:00

abstract：:Administration of carcinogenic doses of urethane to male rats (for 30 days) and to females (for 45 days) caused degranulation of microsomes of livers and lungs to approx. 15 and 35%, respectively. The cholesterol levels also declined more than 50% in urethane-treated rats when compared with controls. Studies on struct...

journal_title：Toxicology letters

authors： Renuka,Dani HM

更新日期：1983-01-01 00:00:00

abstract：:A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...

journal_title：Toxicology letters

authors： Okey AB,Riddick DS,Harper PA

更新日期：1994-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were treated i.p. with different doses of bromobenzene (0, 0.1, 0.2, 0.3 and 0.5 mmol/kg) in corn oil for 4 weeks. The animals were killed 24 h after the end of the treatment for hepatic drug metabolism studies. A significant induction of the activities of microsomal aniline hydroxylase (51%) ...

journal_title：Toxicology letters

authors： Chakrabarti S

更新日期：1984-01-01 00:00:00

abstract：:The binding of [3H]aflatoxin B1 (AFB1) to the DNA, RNA and protein of liver after i.p. administration to rats with and without ethanol pretreatment was studied. The quantities of AFB1 binding to DNA and RNA were significantly increased by ethanol pretreatment but the formation of protein adducts was not affected. AFB1...

journal_title：Toxicology letters

authors： Toskulkao C,Glinsukon T

更新日期：1986-02-01 00:00:00

abstract：:Previous studies have suggested that elevated blood homocysteic acid (HCA) levels increased the risk of Alzheimer's disease (AD), but the underlying mechanisms are unclear. Herein, we studied the neuronal toxicity of HCA and the underlying mechanisms in HT-22 cells. Results showed that HCA induced cell death in concen...

journal_title：Toxicology letters

authors： Tan M,Ouyang Y,Jin M,Chen M,Liu P,Chao X,Chen Z,Chen X,Ramassamy C,Gao Y,Pi R

更新日期：2013-10-23 00:00:00

abstract：:The availability of different chemical forms of mercury (Hg) was studied in primary cultures of rat hepatocytes incubated with mercuric acetate (HgAc), mercuric diethyldithiocarbamate (Hg(DTC)2) or methyl mercuric chloride (MeHgCl), labelled with 203Hg. The uptake of Hg was linearly related to the concentration in the...

journal_title：Toxicology letters

authors： Hellström-Lindahl E,Oskarsson A

更新日期：1989-10-01 00:00:00

abstract：:The incidence of spontaneous neoplasms in outbred, inbred and F1 hybrid strains was compared using the Charles River-CD rat and mouse, the F344 rat, and B6C3HF1 mouse. These strains are commonly used in carcinogenic studies. Each strain has a consistent pattern of tumor occurrence; testicular, pituitary and lymphoreti...

journal_title：Toxicology letters

authors： Sher SP,Jensen RD,Bokelman DL

更新日期：1982-04-01 00:00:00

abstract：:Trichothecenes are mycotoxins which produce lethal toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a hig...

journal_title：Toxicology letters

authors： Feuerstein G,Leader P,Siren AL,Braquet P

更新日期：1987-10-01 00:00:00