Abstract：
:Using the comet assay technique, this paper examines the protection from the cisplatin-induced genetic damage in mouse bone marrow cells provided by cedron-leaf infusion. Animals were separated into six groups: (I) untreated, (II) negative control, (III) treated with cedron-leaf infusion (5%), (IV) treated with cisplatin (6 mg/kg b.w.), (V) pretreated with infusion and treated with cisplatin and (VI) positive control (cyclophosphamide, 20 mg/kg b.w.). Based on the tail moment values found, four types of comets were distinguished. No statistical differences (P<0.01) were found between untreated animals, negative control and infusion treated mice. As expected, treatment of mice with a single dose of cis-DDP-induced genetic damage and the pretreatment with infusion prior to cis-DDP injection inhibited the capacity of cisplatin to induce genetic damage. Cell viability was up to 90% in all cases. The results suggest that infusion could exert its in vivo antigenotoxic action by enhancing the antioxidant status of bone marrow cells. The found could be attributed to its scavenging potency towards free radicals.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Zamorano-Ponce E,Fernández J,Vargas G,Rivera P,Carballo MAdoi
10.1016/j.toxlet.2004.04.002keywords:
subject
Has Abstractpub_date
2004-08-30 00:00:00pages
85-90issue
1eissn
0378-4274issn
1879-3169pii
S037842740400205Xjournal_volume
152pub_type
杂志文章abstract：:The chronic toxic effects of chromium (2.6 mg/1) on the carbohydrate metabolism of a teleost fish, Channa punctatus were examined after 60 and 120 days of exposure. After 60 days the lactic acid content of blood and muscles was increased but liver lactic acid content decreased. Liver glycogen was also depleted. The ac...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90003-6
更新日期：1983-04-01 00:00:00
abstract：:α-asarone is a natural phenylpropene found in several plants, which are widely used for flavoring foods and treating diseases. Previous studies have demonstrated that α-asarone has many pharmacological functions, while some reports indicated its toxicity. However, little is known about its cardiovascular effects. This...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2020.02.003
更新日期：2020-05-15 00:00:00
abstract：:Dopaminergic system dysfunction is proved to be a possible mechanism in acrylamide (ACR) -induced neurotoxicity. The neurotransmitter dopamine (DA) has an increasingly important role in the dopaminergic system. Thus, the goal of this study is to evaluate effects of ACR on dopamine and its metabolite levels, dopamine t...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.04.017
更新日期：2015-07-02 00:00:00
abstract：:Euphorbia milii (Euphorbiaceae) is a decorative plant used in gardens and living fences. In China, it has also been employed in herbal remedies for hepatitis and abdominal edema. Since E. milii latex--lyophilized or in natura--proved to be a potent plant molluscicide, its toxicity to non-target organisms has been comp...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(03)00303-5
更新日期：2003-11-30 00:00:00
abstract：OBJECTIVE:To evaluate manganese in exhaled breath condensate (Mn-EBC) as an indicator of exposure to fumes from metal inert gas welding process. METHODS:We collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and chrom...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.01.034
更新日期：2014-04-07 00:00:00
abstract：:Oxidative damage plays a key role in septic shock induced by lipopolysaccharide (LPS) which is known to enhance the formation of reactive oxygen species (ROS). In this study, biochemical parameters indicative of oxidative stress were tested in the rat heart following LPS challenge, with and without pretreatment with t...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(01)00369-1
更新日期：2001-08-06 00:00:00
abstract：:Guidelines concerning the preclinical safety assessment of therapeutic proteins are available, e.g. in the European Community (EC Notes for Guidance). Unlike rather rigidly prescribing test systems such as those known for chemical substances, it is agreed that for biotechnologically-produced products, testing may be q...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(92)90206-y
更新日期：1992-12-01 00:00:00
abstract：:N-acetyl-beta-D-glucosaminidase (NAG) activity in urine was measured in patients with 'itai-itai' disease, from chronically advanced cadmium poisoning. Elevation of NAG activity, however, was not so marked as that of beta 2-microglobulin (beta 2-MG) in the urine of patients and suspected patients. We conclude that the...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90193-5
更新日期：1983-05-01 00:00:00
abstract：:Effects of vitamin E on cell morphology and cellular protein thiols under oxidative stress was investigated in cultured rat hepatocytes with different vitamin E status. Hepatocytes were incubated in the presence or absence of 100 microM alpha-tocopherol succinate for 24 h then treated with 1.5 mM t-butyl hydroperoxide...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(96)03793-9
更新日期：1996-12-16 00:00:00
abstract：:Furan, a potential human carcinogen, is formed during heat-treatment of food. Previous studies of the genotoxicity of furan have given disparate results. Hence, there is a need for complementary data to clarify the mechanism behind the carcinogenicity of furan. In this study, we have used the flow cytometer-based micr...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2006.08.020
更新日期：2007-02-28 00:00:00
abstract：:Dichloroacetic acid (DCA) is a complete hepatocarcinogen and tumor promoter in the male B6C3F1 mouse. Published reports indicate that the compound is non-genotoxic. This study examines possible non-genotoxic (epigenetic) mechanisms by which DCA elicits its carcinogenic response. Correlative biochemical, pathologic and...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(95)03409-9
更新日期：1995-11-01 00:00:00
abstract：:The intestinal epithelium is the first barrier against food contaminants and is highly sensitive to Fusarium toxins, especially deoxynivalenol (DON) and zearalenone (ZEA). Here, we explored the effects of low doses of DON and/or ZEA in naturally moldy diets on intestinal functions in piglets, including inflammatory re...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2020.07.032
更新日期：2020-10-15 00:00:00
abstract：:Aminoglycoside antibiotics play an integral role in antimicrobial chemotherapy. Unfortunately, these drugs are known to cause nephrotoxicity in man and experimental animals. In fact, the incidence of renal dysfunction during the course of clinical treatment with aminoglycoside antibiotics is approximately 10%. Over th...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(90)90067-v
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Vitamin A is widely used in cosmetic preparations. Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites. METHODS:Two groups of 14 female volunteer...
journal_title：Toxicology letters
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.toxlet.2005.09.029
更新日期：2006-05-05 00:00:00
abstract：:Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli wa...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(96)03637-5
更新日期：1996-04-01 00:00:00
abstract：:Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutan...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(86)90094-9
更新日期：1986-02-01 00:00:00
abstract：:Superparamagnetic iron oxide nanoparticles (SPION) are used as high-sensitive enhancer for magnetic resonance imaging, where they represent a promising tool for early diagnosis of destructive diseases such as rheumatoid arthritis (RA). Since we could demonstrate that professional phagocytes are activated by amino-poly...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.01.003
更新日期：2016-03-14 00:00:00
abstract：:A short-term initiation/promotion bioassay has been developed in rat liver using putative preneoplastic foci as the endpoint for the detection of chemical carcinogens. The two protocols of the bioassay used in this study were varied according to the time 2/3 partial hepatectomy was performed in relation to when the in...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90177-1
更新日期：1982-07-01 00:00:00
abstract：:Risk assessment of xenobiotics is a qualitative and quantitative assessment of toxic properties conventionally based on data resulting from tests in animals exposed to the substance. The assessment of dose-effect relationship includes evaluation of exposure at the site of action. More recently, emphasis is put on unde...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(01)00291-0
更新日期：2001-03-31 00:00:00
abstract：:In order to assess the applicability of the micronucleus (MN) and G2 assays as biomarkers of in vitro radiosensitivity and cancer susceptibility, we investigated the inter- and intra-individual variation of these endpoints. For the MN assay unstimulated blood cultures from 57 healthy donors were exposed in vitro to 3....
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.12.044
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:The epithelial to mesenchymal transition (EMT) contributes to fibrosis during silicosis. Zinc finger CCCH-type containing 4 protein (ZC3H4) is a novel CCCH-type zinc finger protein that activates inflammation in pulmonary macrophages during silicosis. However, whether ZC3H4 is involved in EMT during silicosi...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.02.014
更新日期：2019-06-01 00:00:00
abstract：:The effects of selenium on cellular toxicity and histochemical distribution of mercury were examined in a cell culture system of mouse peritoneal macrophages. Selenium protected against the toxicity of mercury in cultures exposed to 4 microM of mercuric chloride. Selenomethionine caused a significant increase in cell ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(89)90144-6
更新日期：1989-06-01 00:00:00
abstract：:Styrene and its chiral main metabolite styrene-7.8-oxide are well characterized regarding their cytotoxic, genotoxic and neurotoxic properties. To our knowledge, no data exist on the influence of styrene and styrene-7.8-oxide on immune reactions. Epidemiological studies suggest that exposure to environmental pollutant...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.06.014
更新日期：2006-01-05 00:00:00
abstract：:Lithocholic acid (LCA) supplementation in the diet results in intrahepatic cholestasis and bile infarcts. Previously we showed that an innate immune response is critical for cholestatic liver injury in the bile duct ligated mice. Thus, the purpose of this study was to investigate the role of neutrophils in the mechani...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.04.001
更新日期：2014-07-03 00:00:00
abstract：:We have previously shown that rituximab has a significant radiosensitizing effect on Raji cells in vitro. To investigate whether calcium signals participate in rituximab- and radiation-induced cell death in Raji cells, confocal laser scanning microscopy was used to detect kinetic changes in intracellular free calcium ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.12.018
更新日期：2012-03-25 00:00:00
abstract：:This study was conducted to evaluate whether vitamin C (VC) was associated with total antioxidant status (TAS) in human plasma and to determine the usefulness of VC on TAS in the treatment of patients with paraquat poisoning. VC and TAS were measured in 56 healthy subjects. Then, various concentrations (1-100 mg/dl) o...
journal_title：Toxicology letters
pub_type： 临床试验,杂志文章
doi：10.1016/s0378-4274(01)00431-3
更新日期：2002-01-05 00:00:00
abstract：BACKGROUND:GAPDH, well known for its house-keeping functions, has also been shown to be involved in cell injury, apoptosis and death under conditions of stress such as starvation, chemical injury and oxidative stress. This study examines the effect of GAPDH knockdown on cell injury in response to Rotenone. METHODS:GAP...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.02.017
更新日期：2015-05-05 00:00:00
abstract：:When considering the state of the art in toxicology from an analytical perspective, the key developments relate to three major areas. (1) Forensic horizon: Today forensic analysis has broadened its scope dramatically, to include workplace toxicology, drug abuse testing, drugs and driving, doping, environmental and vet...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(98)00293-8
更新日期：1998-12-28 00:00:00
abstract：:The activity of femoral-epiphyseal acid phosphatase, a marker enzyme of bone resorption induced by parathyroid hormone, was increased by a single oral dose of Zn 100 mg/kg to rats. This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supp...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90276-x
更新日期：1983-10-01 00:00:00
abstract：:Mercury, one of the widespread pollutants in the world, induces oxidative stress and dysfunction in many cell types. Alveolar type II epithelial cells are known to be vulnerable to oxidative stress. Alveolar type II epithelial cells produce and secrete surfactants to maintain morphological organization, biophysical fu...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.02.003
更新日期：2010-05-04 00:00:00
