Abstract:
:The possible role of acetylcholine receptors on the HgCl(2)-induced dopamine (DA) release from rat striatum was investigated by using in vivo brain microdialysis technique after administration of selective nicotinic and muscarinic receptor antagonists, mecamylamine and atropine, respectively. Intrastriatal infusion of 1mM HgCl(2) increased striatal DA to 1717.2+/-375.4% respect to basal levels. Infusion of 1mM HgCl(2) in 1mM mecamylamine pretreated animals produced an increase on striatal DA levels 58% less than that induced in non-pretreated animals. In the case of atropine, this treatment reduced 62% the effect produced by HgCl(2) as compared to non-pretreated rats. These data show that acetylcholine receptors could participate on HgCl(2)-induced dopamine release since administration of nicotinic and muscarinic receptor antagonists reduces HgCl(2) effects on DA release.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Vidal L,Durán R,Faro LR,Alfonso Mdoi
10.1016/j.toxlet.2008.03.008subject
Has Abstractpub_date
2008-05-30 00:00:00pages
181-4issue
3eissn
0378-4274issn
1879-3169pii
S0378-4274(08)00082-9journal_volume
178pub_type
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