abstract：:Hypolipidemic and cardioprotective effects of statins can be associated with the development of myopathies and new-onset type 2 diabetes. These adverse effects may be related to increased oxidative stress. The plant extract silymarin (SM) is known for its antioxidant and anti-inflammatory actions. We tested the hypoth...

journal_title：Physiological research

authors： Marková I,Malínská H,Hüttl M,Miklánková D,Oliyarnyk O,Poruba M,Rácová Z,Kazdová L,Večeřa R

更新日期：2021-01-14 00:00:00

abstract：:We report that decreased expression of miR-30c in tumor compared to adjacent tissue is sex-dependent in colorectal cancer (CRC) patients. High expression of miR-30c was associated with better survival in the whole cohort. When the cohort was split into male and female subcohorts, decreased miR-30c expression in tumor ...

journal_title：Physiological research

authors： Herichova I,Reis R,Hasakova K,Vician M

更新日期：2020-12-31 00:00:00

abstract：:The main role of research in medicine is to provide relevant knowledge which, after successful translation to clinical practice, improves the quality of healthcare. The sex bias which is still present in the majority of research disciplines prefers male subjects despite legislation changes in the US grant agencies and...

journal_title：Physiological research

authors： Plevkova J,Brozmanova M,Harsanyiova J,Sterusky M,Honetschlager J,Buday T

更新日期：2020-12-31 00:00:00

abstract：:We investigated whether polyethylene glycol-coated Fe3O4 nanoparticles (IONs), acute stress and their combination modifies vascular functions, nitric oxide synthase (NOS) activity, mean arterial pressure (MAP) as well as hepcidin and ferritin H gene expressions in Wistar-Kyoto rats. Rats were divided into control, ION...

journal_title：Physiological research

authors： Líšková S,Bališ P,Mičurová A,Kluknavský M,Okuliarová M,Puzserová A,Škrátek M,Sekaj I,Maňka J,Valovič P,Bernátová I

更新日期：2020-12-22 00:00:00

abstract：:Atrial fibrillation is associated with atrial remodeling, in which connexin 43 (Cx43) and cell hypertrophy play important roles. In this study, apelin-13, an aliphatic peptide, was used to explore the protective effects of the adenosine monophosphate-activated protein kinase (AMPK)/mTOR signaling pathway on Cx43 expre...

journal_title：Physiological research

authors： Chen Y,Qiao X,Zhang L,Li X,Liu Q

更新日期：2020-11-16 00:00:00

abstract：:Sensorineural hearing loss and vertigo, resulting from lesions in the sensory epithelium of the inner ear, have a high incidence worldwide. The sensory epithelium of the inner ear may exhibit extreme degeneration and is transformed to flat epithelium (FE) in humans and mice with profound sensorineural hearing loss and...

journal_title：Physiological research

authors： He L,Guo JY,Liu K,Wang GP,Gong SS

更新日期：2020-11-16 00:00:00

abstract：:Methylphenidate is commonly used for the treatment of attention deficit hyperactivity disorder. The cardiovascular safety of methylphenidate has been a subject of debate with some studies indicating that methylphenidate increases the likelihood of experiencing a myocardial infarction. However, it is unknown whether me...

journal_title：Physiological research

authors： Seeley SL,D'Souza MS,Stoops TS,Rorabaugh BR

更新日期：2020-11-16 00:00:00

abstract：:Familial hypocalciuric hypercalcemia (FHH) type 1, caused by a heterozygous inactivating mutation of the gene encoding the calcium-sensing receptor (CaSR), is characterized by mild to moderate hypercalcemia, hypocalciuria and inappropriately normal or elevated parathyroid hormone (PTH). FHH must be differentiated from...

journal_title：Physiological research

authors： Zajíčková K,Dvořáková M,Moravcová J,Včelák J,Goltzman D

更新日期：2020-09-30 00:00:00

abstract：:Anthropogenic environmental pollutants affect many physiological, biochemical, and endocrine actions as reproduction, metabolism, immunity, behavior and as such can interfere with any aspect of hormone action. Microbiota and their genes, microbiome, a large body of microorganisms, first of all bacteria and co-existing...

journal_title：Physiological research

authors： Hampl R,Stárka L

更新日期：2020-09-30 00:00:00

abstract：:Hypersensitive pain response is observed in patients with Parkinson's disease (PD). However, the signal pathways leading to hyperalgesia still need to be clarified. Chronic oxidative stress is one of the hallmarks of PD pathophysiology. Since the midbrain periaqueductal gray (PAG) is an important component of the desc...

journal_title：Physiological research

authors： Zhang W,Sun L,Yang X,Wang R,Wang H

更新日期：2020-08-31 00:00:00

abstract：:The influence of cilostazol on learning and memory, and cyclin D1 expression in the cerebral cortex of rats with chronic cerebral ischemia were investigated. A chronic cerebral ischemia model was established using the permanent bilateral common carotid artery occlusion method (2VO), learning and memory capacity was de...

journal_title：Physiological research

authors： Wei AX,Shao MY,Liu Y,Sun Y,Wang LM,Ma XY,Mang J,Xu ZX

更新日期：2020-08-31 00:00:00

abstract：:Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining normal blood pressure, kidney function and water and electrolyte homeostasis. The renal microvasculature expresses a multitude of receptors mediating vasodilation and vasoconstriction, which can influence glomerular blood f...

journal_title：Physiological research

authors： Guan Z,Makled MN,Inscho EW

更新日期：2020-07-16 00:00:00

abstract：:Methamphetamine (MA), as a psychostimulant drug that crosses the placental barrier, may disrupt the development of social play. The present study aims to examine the effect of prenatal MA (5 mg/kg) exposure during the first (gestational day (GD) 1-11) or second (GD 12-22) halves of prenatal development of rats on soci...

journal_title：Physiological research

authors： Ševčíková M,Petríková I,Šlamberová R

更新日期：2020-04-30 00:00:00

abstract：:New knowledge about the neural aspects of cough has revealed a complex network of pathways that initiate cough. The effect of inflammation on cough neural processing occurs at multiple peripheral and central sites within the nervous system. Evidence exists that direct or indirect neuroimmune interaction induces a comp...

journal_title：Physiological research

authors： Kunc P,Fabry J,Lucanska M,Zatko T,Grendar M,Pecova R

更新日期：2020-03-27 00:00:00

abstract：:Cough is one of the most important defensive reflexes. However, extensive non- productive cough is a harmful mechanism leading to the damage of human airways. Cough is initiated by activation of vagal afferents in the airways. The site of their convergence is particularly the nucleus of the solitary tract (nTS). The s...

journal_title：Physiological research

authors： Lucanska M,Hajtman A,Calkovsky V,Kunc P,Pecova R

更新日期：2020-03-27 00:00:00

abstract：:Nephrotoxicity of cisplatin (CP) involves renal oxidative stress and inflammation, and sesamin (a major liganin in many plants) has strong antioxidant and antiinflammatory actions. Therefore, we investigated here the possible mitigative action of sesamin on CP nephrotoxicity in rats. Sesamin was given orally (5 mg/kg/...

journal_title：Physiological research

authors： Ali BH,Al Salam S,Al Suleimani Y,Al Za'abi M,Ashique M,Manoj P,Sudhadevi M,Al Tobi M,Nemmar A

更新日期：2020-02-19 00:00:00

abstract：:Endometrial cancer is one of the most frequent gynecological malignancies present in more than 95 % of all uterine cancers. In spite of that, screening of such disease is not commonly performed in clinical practice due to enormous costs and relatively low sensitivity. Therefore, developing an effective screening test ...

journal_title：Physiological research

authors： Kacírová M,Bober P,Alexovič M,Tomková Z,Tkáčiková S,Talian I,Mederová L,Bérešová D,Tóth R,Andrašina I,Kožlejová Z,Kilík R,Divín R,Sabo J

更新日期：2019-12-30 00:00:00

abstract：:The laser radiation absorbed by cells induces production of reactive oxygen species (ROS), followed by the development of oxidative stress. Proteins are major targets for ROS due to their abundance in biological systems. The aim of the present pilot study was to examine the effects of transcutaneous laser blood irradi...

journal_title：Physiological research

authors： Kilik R,Bober P,Ropovik I,Beňačka R,Genči J,Nečas A,Sabo J

更新日期：2019-12-30 00:00:00

abstract：:To compare serum adiponectin changes across the menstrual cycle between normal weight and overweight/obese young women and its correlation with serum estradiol. Young women (n=56) with regular menstrual cycle had been grouped according to their BMI into normal weight group (n=26) and overweight /obese group (n=30). Bl...

journal_title：Physiological research

authors： Salem AM,Latif R,Rafique N

更新日期：2019-12-30 00:00:00

abstract：:Chronic kidney disease adversely affects the structure and metabolism of bone tissue, which may be a result of disturbed biochemical processes in adipose tissue. Renal replacement therapy is a life-saving therapy but it does not restore all metabolic functions and sometimes even escalates some disturbances. The study ...

journal_title：Physiological research

authors： Marchelek-Myśliwiec M,Dziedziejko V,Nowosiad-Magda M,Wiśniewska M,Safranow K,Pawlik A,Domański L,Dołęgowska K,Dołęgowska B,Stępniewska J,Ciechanowski K

更新日期：2019-12-30 00:00:00

abstract：:Oculometric behaviour assessed by pupil response provides important information about central autonomic activity and emotional regulation. However, studies regarding pupil response to emotional stimuli in adolescent depression are rare. We aimed to study emotional-linked pupil response in adolescent depression. Twenty...

journal_title：Physiological research

authors： Sekaninova N,Ondrejka I,Bona Olexova L,Visnovcova Z,Mestanik M,Cesnekova D,Hamrakova A,Tonhajzerova I

更新日期：2019-12-20 00:00:00

abstract：:Methamphetamine is one of the most abused hard drugs in the Czech Republic. Its popularity is high not only in Eastern Bloc of Europe but is growing in other countries around the world, including the United States. In addition, methamphetamine abuse increases in drug addicts during pregnancy. Although research into th...

journal_title：Physiological research

authors： Šlamberová R

更新日期：2019-12-20 00:00:00

abstract：:Store-operated calcium entry (SOCE) is one of regulatory mechanisms which regulates Ca2+ cycling in the heart. SOCE alterations in pathological conditions contribute to progression of heart failure and cardiac hypertrophy by multiple signaling pathways such as Cn/NFAT and CaMKII/MEF2. Several components mediating SOCE...

journal_title：Physiological research

authors： Čendula R,Dragún M,Gažová A,Kyselovič J,Hulman M,Máťuš M

更新日期：2019-11-30 00:00:00

abstract：:Evaluation of possible interactions with enzymes of drug metabolism is an important part of studies on safety and, in general, on the properties of any drug or biologically active compound. Here, focus is given on interactions of three sesquiterpenes (beta-caryophyllene oxide (CAO), trans-nerolidol (tNER) and farnesol...

journal_title：Physiological research

authors： Špičáková A,Bazgier V,Skálová L,Otyepka M,Anzenbacher P

更新日期：2019-11-22 00:00:00

abstract：:Epoxyeicosatrienoic acids (EETs) are also known as epoxyeicosanoids that have renal and cardiovascular actions. These renal and cardiovascular actions can be regulated by soluble epoxide hydrolase (sEH) that degrades and inactivates EETs. Extensive animal hypertension studies have determined that vascular, epithelial ...

journal_title：Physiological research

authors： Imig JD

更新日期：2019-10-25 00:00:00

abstract：:Metabolic syndrome and one of its manifestations, essential hypertension, is an important cause of worldwide morbidity and mortality. Morbidity and mortality associated with hypertension are caused by organ complications. Previously we revealed a decrease of blood pressure and an amelioration of cardiac fibrosis in a ...

journal_title：Physiological research

authors： Mirchi LF,Chylíková B,Janků M,Šeda O,Liška F

更新日期：2019-10-25 00:00:00

abstract：:Endothelin alters central sympathetic responses, but the resultant effects on arrhythmogenesis are unknown. We examined ventricular tachyarrhythmias after endothelin receptor-A blockade in the brain of Wistar rats with acute myocardial infarction. For this aim, BQ-123 (n=6) or phosphate-buffered saline (n=6) were inje...

journal_title：Physiological research

authors： Lekkas P,Georgiou ES,Kontonika M,Mouchtouri ET,Mourouzis I,Pantos C,Kolettis TM

更新日期：2019-10-25 00:00:00

abstract：:Parenteral nutrition-associated liver disease (PNALD) is a severe complication in patients completely dependent on parenteral nutrition (PN). The gold diagnostic standard, liver biopsy, is associated with significant health risk and therefore its use is limited. MicroRNAs (miRNAs) are small non-coding regulatory RNA m...

journal_title：Physiological research

authors： Cahová M,Daňková H,Heczková M,Brátová M,Ďásková N,Baštová H,Gojda J,Wohl P

更新日期：2019-08-29 00:00:00

abstract：:Precise and efficient endocytosis is critical for sustained neurotransmission during continuous neuronal activity. Endocytosis is a prerequisite for maintaining the auditory function. However, the differences between the patterns of endocytosis in cochlear inner hair cells (IHCs) and outer hair cells (OHCs) remain unc...

journal_title：Physiological research

authors： Li S,Yu S,Ding T,Yan A,Qi Y,Gong S,Tang S,Liu K

更新日期：2019-08-29 00:00:00

abstract：:To compare circulating pigment epithelium derived factor (PEDF) levels in type 2 diabetes patients (T2D) with and without metabolic syndrome (MetS+/-) to healthy controls and assess PEDF association with plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF) as markers of endothelial dysfunction. Fi...

journal_title：Physiological research

authors： Karasek D,Spurna J,Kubickova V,Krystynik O,Cibickova L,Schovanek J,Goldmannova D

更新日期：2019-06-30 00:00:00

abstract：:Obstructive sleep apnea (OSA) has been demonstrated to be implicated in disorder of insulin secretion and diabetes mellitus. In this study, we aimed to evaluate the protective role of tempol, a powerful antioxidant, in chronic intermittent hypoxia (IH)-induced pancreatic injury. The rat model of OSA was established by...

journal_title：Physiological research

authors： Wang Y,Ai L,Hai B,Cao Y,Li R,Li H,Li Y

更新日期：2019-06-30 00:00:00

abstract：:Neutral trehalase 1 (Nth1) from Saccharomyces cerevisiae catalyzes disaccharide trehalose hydrolysis and helps yeast to survive adverse conditions, such as heat shock, starvation or oxidative stress. 14-3-3 proteins, master regulators of hundreds of partner proteins, participate in many key cellular processes. Nth1 is...

journal_title：Physiological research

authors： Alblova M,Smidova A,Kalabova D,Lentini Santo D,Obsil T,Obsilova V

更新日期：2019-04-30 00:00:00

abstract：:Mammalian Meckel´s cartilage is a temporary structure associated with mandible development. Notably, its elimination is not executed by apoptosis, and autophagy was suggested as the major mechanism. Simultaneous reports point to pro-apoptotic caspases as novel participants in autophagic pathways in general. The aim of...

journal_title：Physiological research

authors： Bíliková P,Švandová E,Veselá B,Doubek J,Poliard A,Matalová E

更新日期：2019-03-06 00:00:00

abstract：:Hyperbaric oxygen (HBO) therapy, i.e. breathing pure oxygen under increased environmental pressures serves as a treatment for diverse medical conditions. However, elevated oxygen concentration can be detrimental to central nervous system or lungs. Our study aimed to evaluate the effects of repeated exposure to HBO on ...

journal_title：Physiological research

authors： Dejmek J,Kohoutová M,Kripnerová M,Čedíková M,Tůma Z,Babuška V,Bolek L,Kuncová J

更新日期：2018-12-31 00:00:00

abstract：:Hepcidin is a key regulator of iron metabolism and plays an important role in many pathologies. It is increased by iron administration and by inflammation, while erythropoiesis downregulates its expression. It decreases iron availability and thus contributes to anemia of chronic diseases. The aim of the study was to m...

journal_title：Physiological research

authors： Přikryl P,Hrušková Z,Konopásek P,Hladinová Z,Tesař V,Vokurka M

更新日期：2018-12-18 00:00:00

abstract：:Oxidative stress markers are usually measured in plasma, a stable environment for biomarkers. Blood collection is invasive, but the use of alternative biofluids is limited, due to high variability. In this study, we aimed to establish reference values for oxidative stress markers in plasma, urine and saliva of adult, ...

journal_title：Physiological research

authors： Gyurászová M,Kovalčíková A,Janšáková K,Šebeková K,Celec P,Tóthová Ľ

更新日期：2018-12-18 00:00:00

abstract：:We measured plasma concentrations, adipose tissue and placental mRNA expression of hepatokines fetuin A, fetuin B and fibroblast growth factor 21 (FGF21) in 12 healthy pregnant women (P group), 12 pregnant women with gestational diabetes (GDM) and 10 healthy non-pregnant women (N group) to explore their potential role...

journal_title：Physiological research

authors： Šimják P,Cinkajzlová A,Anderlová K,Kloučková J,Kratochvílová H,Lacinová Z,Kaválková P,Krejčí H,Mráz M,Pařízek A,Kršek M,Haluzík M

更新日期：2018-11-28 00:00:00

abstract：:Graves' disease affects approximately 3 % of women and 0.5 % of men. The first-choice therapy is based on the administration of thyrostatic drugs. However, approximately half of patients relapse within two years of discontinuation. These patients must then decide whether to re-initiate thyrostatics, which may have ser...

journal_title：Physiological research

authors： Vejrazkova D,Vcelak J,Vaclavikova E,Vankova M,Zajickova K,Duskova M,Vrbikova J,Bendlova B

更新日期：2018-11-28 00:00:00

abstract：:The present study evaluates the protective role of Quercetin (Quer), against immobilization stress- induced anxiety, depression and cognition alteration in mice using behavioral and biochemical parameters. 24 adult Albino mice were distributed into 2 groups vehicle (n=12; 1 ml/kg) and Quer injected (n=12; 20 mg/kg/ml)...

journal_title：Physiological research

authors： Samad N,Saleem A,Yasmin F,Shehzad MA

更新日期：2018-11-14 00:00:00

abstract：:We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of gamma-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, ...

journal_title：Physiological research

authors： Hofer M,Hoferová Z,Gruzdev A,Dušek L,Falk M

更新日期：2018-11-14 00:00:00