Abstract:
:Cough is one of the most important defensive reflexes. However, extensive non- productive cough is a harmful mechanism leading to the damage of human airways. Cough is initiated by activation of vagal afferents in the airways. The site of their convergence is particularly the nucleus of the solitary tract (nTS). The second-order neurons terminate in the pons, medulla and spinal cord and there is also the cortical and subcortical control of coughing.Upper airway cough syndrome (UACS) - previously postnasal drip syndrome - is one of the most common causes of chronic cough together with asthma and gastroesophageal reflux. The main mechanisms leading to cough in patients with nasal and sinus diseases are postnasal drip, direct irritation of nasal mucosa, inflammation in the lower airways, upper airway inflammation and the cough reflex sensitization. The cough demonstrated by UACS patients is probably due to hypersensitivity of the upper airways sensory nerve or lower airways sensory nerve, or a combination of both. Further studies are needed to clarify this mechanism.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Lucanska M,Hajtman A,Calkovsky V,Kunc P,Pecova Rdoi
10.33549/physiolres.934400subject
Has Abstractpub_date
2020-03-27 00:00:00pages
S35-S42issue
Suppl 1eissn
0862-8408issn
1802-9973pii
934400journal_volume
69pub_type
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pub_type: 杂志文章,评审
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journal_title:Physiological research
pub_type: 杂志文章
doi:
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journal_title:Physiological research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.33549/physiolres.934522
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pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-12-20 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:
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