Changes in STIM isoforms expression and gender-specific alterations in Orai expression in human heart failure.

abstract：:We sought to examine the association between maternal erythrocyte omega-3, omega-6 and trans fatty acids and risk of preeclampsia. We conducted a case-control study of 170 women with proteinuric, pregnancy-induced hypertension and 185 normotensive pregnant women who delivered at Harare Maternity Hospital, Harare, Zimb...

journal_title：Physiological research

authors： Mahomed K,Williams MA,King IB,Mudzamiri S,Woelk GB

更新日期：2007-01-01 00:00:00

abstract：:The laser radiation absorbed by cells induces production of reactive oxygen species (ROS), followed by the development of oxidative stress. Proteins are major targets for ROS due to their abundance in biological systems. The aim of the present pilot study was to examine the effects of transcutaneous laser blood irradi...

journal_title：Physiological research

authors： Kilik R,Bober P,Ropovik I,Beňačka R,Genči J,Nečas A,Sabo J

更新日期：2019-12-30 00:00:00

abstract：:Recent results of the authors have demonstrated that the elevation of extracellular adenosine induced by the combined administration of dipyridamole, a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), a soluble adenosine prodrug, mediates radioprotective effects in mice. Furthermore...

journal_title：Physiological research

authors： Pospísil M,Hofer M,Vacek A,Netíková J,Pipalová I,Viklická S

更新日期：1993-01-01 00:00:00

abstract：:Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining normal blood pressure, kidney function and water and electrolyte homeostasis. The renal microvasculature expresses a multitude of receptors mediating vasodilation and vasoconstriction, which can influence glomerular blood f...

journal_title：Physiological research

authors： Guan Z,Makled MN,Inscho EW

更新日期：2020-07-16 00:00:00

abstract：:An oxidant/antioxidant imbalance is thought to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We hypothesized that antioxidant capacity reflected by erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activities, and serum levels of the l...

journal_title：Physiological research

authors： Kluchová Z,Petrásová D,Joppa P,Dorková Z,Tkácová R

更新日期：2007-01-01 00:00:00

abstract：:This study was designated to estimate protective role of ETA and ETB receptor antagonist against endothelin 1 (ET-1)-induced oxidative stress in lungs and determine whether these effects are mediated by nitric oxide (NO) synthase. Experiments were performed on Wistar rats divided into the following groups: I - saline ...

journal_title：Physiological research

authors： Kleniewska P,Gorąca A

更新日期：2016-11-23 00:00:00

abstract：:Impaired cerebrovascular reactivity (CVR), an important risk factor for future stroke, is affected by a presence carotid stenosis. However, in some cases CVR can be impaired in the absence of carotid stenosis due to several poorly characterized mechanisms. We hypothesized that arterial stiffening as observed in corona...

journal_title：Physiological research

authors： Rucka D,Marek J,Rucklova Z,Lubanda JC,Havranek S,Skvaril J,Varejka P,Chochola M,Karetova D,Korinek J,Linhart A

更新日期：2015-01-01 00:00:00

abstract：:Hypoxic pulmonary vasoconstriction (HPV) occurs in smooth muscle cells (SMC) from small pulmonary arteries (SPA) and is accompanied by increases in free cytoplasmic calcium ([Ca2+]i) and cytoplasmic pH (pHi). SMC from large pulmonary arteries (LPA) relax during hypoxia, and [Ca2+]i and pHi decrease. Increases in pHi a...

journal_title：Physiological research

authors： Madden JA,Keller PA,Kleinman JG

更新日期：2000-01-01 00:00:00

abstract：:The global epidemic of diabetes is of significant concern. Diabetes associated vascular disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also the most rapidly increasing risk factor for cognitive impairment, a silent disease that causes loss of creativity, productivity, and ...

journal_title：Physiological research

authors： Li W,Abdul Y,Ward R,Ergul A

更新日期：2018-06-27 00:00:00

abstract：:Aquaporin proteins (AQPs) are a family of channels expressed in numerous mammalian tissues, where they play a fundamental role in regulating water transport across cell membranes. Based on reports that AQPs are present in the reproductive system and participate in reproductive processes, our aim was to investigate the...

journal_title：Physiological research

authors： Skowronska A,Mlotkowska P,Majewski M,Nielsen S,Skowronski MT

更新日期：2016-11-08 00:00:00

abstract：:Vision is a fascinating example of the interaction of a biological system with the outside world. The first step of translating electromagnetic energy into a biologically recognizable signal involves the phototransduction cascade in retinal photoreceptor cells. Phototransduction is the best studied example of a GTP bi...

journal_title：Physiological research

authors： Jindrová H

更新日期：1998-01-01 00:00:00

abstract：:Fibroblast growth factor-21 (FGF-21) has been recently characterized as a new adipokine. The aim of this study was to assess FGF-21 levels in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationship between FGF-21, disease activity and metabolic status. The levels of FGF-21 in seru...

journal_title：Physiological research

authors： Hulejová H,Andrés Cerezo L,Kuklová M,Pecha O,Vondráček T,Pavelka K,Vencovský J,Haluzík M,Senolt L

更新日期：2012-01-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) has been demonstrated to be implicated in disorder of insulin secretion and diabetes mellitus. In this study, we aimed to evaluate the protective role of tempol, a powerful antioxidant, in chronic intermittent hypoxia (IH)-induced pancreatic injury. The rat model of OSA was established by...

journal_title：Physiological research

authors： Wang Y,Ai L,Hai B,Cao Y,Li R,Li H,Li Y

更新日期：2019-06-30 00:00:00

abstract：:It has been reported that the major function of the sterol regulatory element binding protein 2 (SREBP-2) is to activate preferentially cholesterol biosynthesis in liver and adipose tissue rather than fatty acid synthesis. In the current study, we analyzed the effects of overexpression of human dominant-positive SREBP...

journal_title：Physiological research

authors： Landa V,Zídek V,Mlejnek P,Šimáková M,Šilhavý J,Trnovská J,Kazdová L,Pravenec M

更新日期：2014-01-01 00:00:00

abstract：:As an autoimmune disease, type 1 diabetes mellitus (DM) can be associated with other autoimmune disorders. The aim of this study was to detect subclinically associated autoimmune thyroid disease, coeliac disease, and Addison's disease. The presence of autoantibodies was evaluated with special regard to the control of ...

journal_title：Physiological research

authors： Prázný M,Skrha J,Límanová Z,Vanícková Z,Hilgertová J,Prázná J,Jaresová M,Stríz I

更新日期：2005-01-01 00:00:00

abstract：:The gold standard material in bypass surgery of blood vessels remains the patient's own artery or vein. However, this material may be unavailable, or may suffer vein graft disease. Currently available vascular prostheses, namely polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE), per...

journal_title：Physiological research

authors： Chlupác J,Filová E,Bacáková L

更新日期：2009-01-01 00:00:00

abstract：:Hindlimb unweighting (HU) leads to capillary regression in skeletal muscle. However, the molecular mechanism(s) remains to be elucidated. To gain insight into the regulation of this process, we investigated gene expression of hypoxia-inducible factor-1alpha (HIF-1alpha)vascular endothelial growth factor (VEGF), angiop...

journal_title：Physiological research

authors： Wagatsuma A

更新日期：2008-01-01 00:00:00

abstract：:Metabolic acidosis could occur due to either endogenous acids accumulation or bicarbonate loss from the gastrointestinal tract or commonly from the kidney. This study aimed to investigate the possible underlying mechanism(s) of chronic acidosis-induced cardiac contractile and electrical changes in rats. Twenty four ad...

journal_title：Physiological research

authors： Lasheen NN,Mohamed GF

更新日期：2016-12-13 00:00:00

abstract：:The effects of two non-competitive NMDA antagonists--MK-801 and ketamine--were studied in a model of generalized seizures elicited by s.c. injection of strychnine (2 or 3 mg/kg) in adult rats. The animals were observed in isolation for 30 min after strychnine administration. Pretreatment with MK-801 (0.5 or 2 mg/kg i....

journal_title：Physiological research

authors： Kubová H,Mares P

更新日期：1994-01-01 00:00:00

abstract：:Adiponectin is an adipokine increasing glucose and fatty acid metabolism and improving insulin sensitivity. The aim of this study was to investigate the role of adiponectin in the regulation of adipocyte lipolysis. Human adipocytes isolated from biopsies obtained during surgical operations from 16 non-obese and 17 obe...

journal_title：Physiological research

authors： Wedellová Z,Dietrich J,Siklová-Vítková M,Kološtová K,Kováčiková M,Dušková M,Brož J,Vedral T,Stich V,Polák J

更新日期：2011-01-01 00:00:00

abstract：:We determined and characterized the Mg2+-dependent, Ca2+-stimulated ATPase (Ca-ATPase) activity in cell plasma membranes from the myometrium of pregnant women, and compared these characteristics to those of the active Ca2+-transport already demonstrated in this tissue. Similarly to the Ca2+-transport system, the Ca2+-...

journal_title：Physiological research

authors： Carrera F,Proverbio T,Marín R,Proverbio F

更新日期：2000-01-01 00:00:00

abstract：:The purpose of this study was to determine if there is flow-mediated vasodilation of the femoral artery in response to progressive increases in flow within a physiological range observed in the in vivo experiments. Femoral artery blood flow was determined in conscious rabbits (n = 5) using chronically implanted flowpr...

journal_title：Physiological research

authors： Clifford PS,Madden JA,Hamann JJ,Buckwalter JB,Valic Z

更新日期：2010-01-01 00:00:00

abstract：:Through the analysis of the common apolipoprotein (apo) E gene polymorphism in large Caucasian population study with the PCR and subsequent restriction analysis, we have identified carriers of mutant allele Arg136-->Ser. Both of them (71-years-old female and her 43-years-old son) have normal lipid parameters. We sugge...

journal_title：Physiological research

authors： Hubácek JA,Adámková V,Skodová Z

更新日期：2005-01-01 00:00:00

abstract：:The presence of insulin resistance is frequently found in essential hypertension. There are, however, only sparse data with respect to the potential presence of insulin resistance in patients with secondary hypertension. We have therefore undertaken a study to reveal the potential occurrence of insulin resistance in p...

journal_title：Physiological research

authors： Widimský J Jr,Sindelka G,Haas T,Prázný M,Hilgertová J,Skrha J

更新日期：2000-01-01 00:00:00

abstract：:Insulin is known to increase blood flow in parallel to glucose uptake in skeletal muscle. However, it is not known if an increase in blood flow by itself is associated with an increase in glucose uptake in the absence of hyperinsulinemia. To investigate further this matter, the effect of increased blood flow on forear...

journal_title：Physiological research

authors： Sarabi M,Lind L,Millgard J,Hänni A,Hägg A,Berne C,Lithell H

更新日期：1999-01-01 00:00:00

abstract：:We studied the effect of thiazide-like diuretic--indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) and assessed the involvement of nitric oxide in this process. Six-week-old male SHR were treated with indapamide (1 mg/kg/day) for six weeks. Age-matched SHR were use...

journal_title：Physiological research

authors： Janega P,Kojsová S,Jendeková L,Babál P,Pechánová O

更新日期：2007-01-01 00:00:00

abstract：:In the mammalian neocortex, the calcium-binding protein calretinin is expressed in a subset of cortical interneurons. In the recent years, research on interneurons is one of the most rapidly growing fields in neuroscience. This review summarizes the actual knowledge of the functions of calretinin in neuronal homeostas...

journal_title：Physiological research

authors： Barinka F,Druga R

更新日期：2010-01-01 00:00:00

abstract：:The aim of this study was to obtain a detailed analysis of the relationship between the finger arterial compliance C [ml/mm Hg] and the arterial transmural pressure P(t) [mm Hg]. We constructed a dynamic plethysmograph enabling us to set up a constant pressure P(css) [mm Hg] and a superimposed fast pressure vibration ...

journal_title：Physiological research

authors： Moudr J,Svačinová J,Závodná E,Honzíková N

更新日期：2014-01-01 00:00:00

abstract：:Graves' disease affects approximately 3 % of women and 0.5 % of men. The first-choice therapy is based on the administration of thyrostatic drugs. However, approximately half of patients relapse within two years of discontinuation. These patients must then decide whether to re-initiate thyrostatics, which may have ser...

journal_title：Physiological research

authors： Vejrazkova D,Vcelak J,Vaclavikova E,Vankova M,Zajickova K,Duskova M,Vrbikova J,Bendlova B

更新日期：2018-11-28 00:00:00

abstract：:In this experiment we studied the effect of different pedalling rates during cycling at a constant power output (PO) 132+/-31 W (mean+/-S.D.), corresponding to 50% VO2 max, on the oxygen uptake and the magnitude of the slow component of VO2 kinetics in humans. The PO corresponded to 50% of VO2 max, established during ...

journal_title：Physiological research

authors： Zoladz JA,Duda K,Majerczak J

更新日期：1998-01-01 00:00:00