Abstract：
:Through the analysis of the common apolipoprotein (apo) E gene polymorphism in large Caucasian population study with the PCR and subsequent restriction analysis, we have identified carriers of mutant allele Arg136-->Ser. Both of them (71-years-old female and her 43-years-old son) have normal lipid parameters. We suggest that Arg136-->Ser mutation in apoE is not necessarily connected with elevated lipid levels in all cases. Furthermore, so far unidentified factors (environmental and/or genetic) are important for the development of lipid metabolism disorders in apoE Arg136-->Ser mutation carriers.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Hubácek JA,Adámková V,Skodová Zsubject
Has Abstractpub_date
2005-01-01 00:00:00pages
573-5issue
5eissn
0862-8408issn
1802-9973pii
687journal_volume
54pub_type
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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更新日期：2003-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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doi：10.33549/physiolres.933426
更新日期：2016-10-20 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934598
更新日期：2020-12-31 00:00:00
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pub_type： 杂志文章
doi：10.33549/physiolres.934567
更新日期：2020-12-22 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.934291
更新日期：2019-10-25 00:00:00
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doi：
更新日期：1998-01-01 00:00:00
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doi：
更新日期：2008-01-01 00:00:00
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更新日期：2009-01-01 00:00:00
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doi：
更新日期：2001-01-01 00:00:00
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