Down-regulation of model yeast proteins by ubiquitin-dependent proteolysis.

abstract：:Remote ischemic preconditioning (RIPC) is a novel strategy of protection against ischemia-reperfusion (IR) injury in the heart (and/or other organs) by brief episodes of non-lethal IR in a distant organ/tissue. Importantly, RIPC can be induced noninvasively by limitation of blood flow in the extremity implying the app...

journal_title：Physiological research

authors： Ravingerova T,Farkasova V,Griecsova L,Carnicka S,Murarikova M,Barlaka E,Kolar F,Bartekova M,Lonek L,Slezak J,Lazou A

更新日期：2016-09-19 00:00:00

abstract：:We developed a novel behavioral task in which rats learn to recognize the configuration of objects in an animated scene displayed on a computer screen. The scene consisted of a moving bar and a stationary rectangle. Rats deprived of food were trained to press a lever for reward in a small chamber located in front of t...

journal_title：Physiological research

authors： Nekovárová T,Klement D

更新日期：2006-01-01 00:00:00

abstract：:Calcium cycling is a major determinant of cardiac function. S100A1 is the most abundant member of the calcium-binding S100 protein family in myocardial tissue. S100A1 interacts with a variety of calcium regulatory proteins such as SERCA2a, ryanodine receptors, L-type calcium channels and Na(+)/Ca(2+) exchangers, thus ...

journal_title：Physiological research

authors： Duarte-Costa S,Castro-Ferreira R,Neves JS,Leite-Moreira AF

更新日期：2014-01-01 00:00:00

abstract：:The organization of the neocortical projection to the inferior colliculus (IC) was studied in 36 rats using retrograde transport of horseradish peroxidase (HRP) or horseradish peroxidase conjugated with lectin (WGA-HRP). Projection to the external and dorsal cortices originates in the temporal neocortical areas Te 1, ...

journal_title：Physiological research

authors： Druga R,Syka J,Rajkowska G

更新日期：1997-01-01 00:00:00

abstract：:At present, there are insufficient information about baroreflex sensitivity (BRS) and factors that determine BRS in premature newborns. The objective of this study was to determine the relationship between BRS and the characteristics that reflecting the intrauterine development (gestational age and birth weight), as w...

journal_title：Physiological research

authors： Haskova K,Javorka M,Czippelova B,Zibolen M,Javorka K

更新日期：2017-09-22 00:00:00

abstract：:Our previous studies concerning the role of furosemide-resistant cation leaks in genetic hypertension demonstrated that blood pressure of recombinant inbred strains (derived from F2 hybrids of spontaneously hypertensive and normotensive Brown Norway rats) cosegregated with inward Na+ leak (determined in saline medium)...

journal_title：Physiological research

authors： Bin Talib HK,Zicha J

更新日期：1993-01-01 00:00:00

abstract：:Precise and efficient endocytosis is critical for sustained neurotransmission during continuous neuronal activity. Endocytosis is a prerequisite for maintaining the auditory function. However, the differences between the patterns of endocytosis in cochlear inner hair cells (IHCs) and outer hair cells (OHCs) remain unc...

journal_title：Physiological research

authors： Li S,Yu S,Ding T,Yan A,Qi Y,Gong S,Tang S,Liu K

更新日期：2019-08-29 00:00:00

abstract：:The mitochondrial DNA (mtDNA) amount in cells as the basis for mitochondrial energy generating system, which produces ATP, plays an important role in the fetal development and postnatal morbidity. Isolated human cord blood leukocytes (HCBL) contribute very little to the overall metabolic turnover, but they may serve a...

journal_title：Physiological research

authors： Pejznochová M,Tesarová M,Honzík T,Hansíková H,Magner M,Zeman J

更新日期：2008-01-01 00:00:00

abstract：:For better understanding of pathophysiological processes leading to increased retention of sodium as a consequence of hyperlipidemia, the properties of renal Na,K-ATPase, a key enzyme involved in maintaining sodium homeostasis in the organism, were studied. Enzyme kinetics of renal Na,K-ATPase were used for characteri...

journal_title：Physiological research

authors： Vrbjar N,Mézešová L,Javorková V,Vlkovičová J,Mitašíková M,Dlugošová K,Okruhlicová L,Tribulová N

更新日期：2011-01-01 00:00:00

abstract：:The goal of this study is to evaluate if promotion of angiogenesis by systemic treatment with an antagomir against miR-92a, a well established inhibitor of angiogenesis, will maximize the benefits of exercise on bone. Ten week old female C57BL6/J mice were subjected to two weeks of external load by four point bending....

journal_title：Physiological research

authors： Sengul A,Santisuk R,Xing W,Kesavan C

更新日期：2013-01-01 00:00:00

abstract：:Psychostimulants, including methamphetamine (MA), have neurotoxic effect, especially, if they are targeting CNS during its critical periods of development. The present study was aimed to examine cognitive changes after prenatal and neonatal MA treatment in combination with chronic MA exposure in adulthood of male rats...

journal_title：Physiological research

authors： Hrebíčková I,Ševčíková M,Nohejlová K,Šlamberová R

更新日期：2016-12-22 00:00:00

abstract：:An important mechanism underlying cochlear hair cell (HC) susceptibility to hypoxia/ischemia is the influx of Ca(2+). Two main ATP-dependent mechanisms contribute to maintaining low Ca(2+) levels: uptake of Ca(2+) into intracellular stores via smooth endoplasmic reticulum calcium ATPase (SERCA) and extrusion of Ca(2+)...

journal_title：Physiological research

authors： Amarjargal N,Mazurek B,Haupt H,Andreeva N,Fuchs J,Gross J

更新日期：2008-01-01 00:00:00

abstract：:The effect of Na+-K+-ATPase inhibitor ouabain on the resting membrane potential (Vm) was studied by glass microelectrodes in isolated somatic longitudinal muscles of the earthworm Lumbricus terrestris and compared with frog sartorius muscle. In earthworm muscle, Vm was -49 mV (inside negative) in a reference external ...

journal_title：Physiological research

authors： Volkov EM,Nurullin LF,Svandová I,Nikolsky EE,Vyskocil F

更新日期：2000-01-01 00:00:00

abstract：:Eukaryotic cytochrome c oxidase (CcO), the terminal component of the mitochondrial electron transport chain is a heterooligomeric complex that belongs to the superfamily of heme-copper containing terminal oxidases. The enzyme, composed of both mitochondrially and nuclear encoded subunits, is embedded in the inner mito...

journal_title：Physiological research

authors： Stiburek L,Hansikova H,Tesarova M,Cerna L,Zeman J

更新日期：2006-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) is associated with increased concentration of intracellular calcium, which is pathological and may lead to irreversible damage of cell functions and structures. The aim of our study was to investigate the impact of 6 months vitamin D(3) supplementation (14 000 IU/week) on free cytosolic ca...

journal_title：Physiological research

authors： Morvová M Jr,Lajdová I,Spustová V,Zvarík M,Šikurová L

更新日期：2014-01-01 00:00:00

abstract：:The laser radiation absorbed by cells induces production of reactive oxygen species (ROS), followed by the development of oxidative stress. Proteins are major targets for ROS due to their abundance in biological systems. The aim of the present pilot study was to examine the effects of transcutaneous laser blood irradi...

journal_title：Physiological research

authors： Kilik R,Bober P,Ropovik I,Beňačka R,Genči J,Nečas A,Sabo J

更新日期：2019-12-30 00:00:00

abstract：:Nephrotoxicity of cisplatin (CP) involves renal oxidative stress and inflammation, and sesamin (a major liganin in many plants) has strong antioxidant and antiinflammatory actions. Therefore, we investigated here the possible mitigative action of sesamin on CP nephrotoxicity in rats. Sesamin was given orally (5 mg/kg/...

journal_title：Physiological research

authors： Ali BH,Al Salam S,Al Suleimani Y,Al Za'abi M,Ashique M,Manoj P,Sudhadevi M,Al Tobi M,Nemmar A

更新日期：2020-02-19 00:00:00

abstract：:Aquaporin proteins (AQPs) are a family of channels expressed in numerous mammalian tissues, where they play a fundamental role in regulating water transport across cell membranes. Based on reports that AQPs are present in the reproductive system and participate in reproductive processes, our aim was to investigate the...

journal_title：Physiological research

authors： Skowronska A,Mlotkowska P,Majewski M,Nielsen S,Skowronski MT

更新日期：2016-11-08 00:00:00

abstract：:Adiponectin is an adipokine increasing glucose and fatty acid metabolism and improving insulin sensitivity. The aim of this study was to investigate the role of adiponectin in the regulation of adipocyte lipolysis. Human adipocytes isolated from biopsies obtained during surgical operations from 16 non-obese and 17 obe...

journal_title：Physiological research

authors： Wedellová Z,Dietrich J,Siklová-Vítková M,Kološtová K,Kováčiková M,Dušková M,Brož J,Vedral T,Stich V,Polák J

更新日期：2011-01-01 00:00:00

abstract：:The most common etiology of non-syndromic monogenic obesity are mutations in gene for the Melanocortin-4 receptor (MC485) with variable prevalence in different countries (1.2-6.3 % of obese children). The aim of our study was 1) to search for MC4R mutations in obese children in Slovakia and compare their prevalence wi...

journal_title：Physiological research

authors： Stanikova D,Surova M,Ticha L,Petrasova M,Virgova D,Huckova M,Skopkova M,Lobotkova D,Valentinova L,Mokan M,Stanik J,Klimes I,Gasperikova D

更新日期：2015-01-01 00:00:00

abstract：:Expression of the immediate-early gene c-fos, a marker of neuronal activation was employed in adult anesthetized non-decerebrate cats, in order to localize the brainstem neuronal populations functionally related to sniff-like (gasp-like) aspiration reflex (AR). Tissues were immunoprocessed using an antibody raised aga...

journal_title：Physiological research

authors： Jakus J,Halasová E,Poliacek I,Tomori Z,Stránsky A

更新日期：2004-01-01 00:00:00

abstract：:Pulmonary hypertension (PH) unresponsive to pharmacological intervention is considered a contraindication for orthotopic heart transplantation (OHTX) due to risk of postoperative right-heart failure. In this prospective study, we describe our experience with a treatment strategy of improving severe PH in heart transpl...

journal_title：Physiological research

authors： Kettner J,Dorazilová Z,Netuka I,Malý J,Al-Hiti H,Melenovský V,Skalský I,Říha H,Málek I,Kautzner J,Pirk J

更新日期：2011-01-01 00:00:00

abstract：:The effect of increased coronary flow on transmural ventricular repolarization was investigated in six pentobabital-anesthetized sheep. Fresh blood at 10 ml/min was injected into the left circumflex coronary artery (LCX) in addition to the normal coronary flow. Unipolar electrocardiograms were simultaneously registere...

journal_title：Physiological research

authors： Zhang YZ,He B,Wang LX

更新日期：2007-01-01 00:00:00

abstract：:Male and female rats were given oestradiol benzoate (1 mg s.c. twice a week for 3 weeks) and/or sodium nitroprusside (SN), a donor of nitric oxide (NO), which was administered in their food in amounts of 0.2 or 0.6 mg/rat/day. Neither oestradiol-induced hypertrophy of the hypophysis, nor the serum prolactin (PRL) leve...

journal_title：Physiological research

authors： Nedvídková J,Schreiber V

更新日期：1992-01-01 00:00:00

abstract：:Increased excitability of the spinal motor system has been observed after loud and unexpected acoustic stimuli (AS) preceding H-reflexes. The paradigm has been proposed as an electrophysiological marker of reticulospinal tract activity in humans. The brainstem reticular formation also maintains dense anatomical interc...

journal_title：Physiological research

authors： Ilic TV,Pötter-Nerger M,Holler I,Siebner HR,Ilic NV,Deuschl G,Volkmann J

更新日期：2011-01-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) therapy, i.e. breathing pure oxygen under increased environmental pressures serves as a treatment for diverse medical conditions. However, elevated oxygen concentration can be detrimental to central nervous system or lungs. Our study aimed to evaluate the effects of repeated exposure to HBO on ...

journal_title：Physiological research

authors： Dejmek J,Kohoutová M,Kripnerová M,Čedíková M,Tůma Z,Babuška V,Bolek L,Kuncová J

更新日期：2018-12-31 00:00:00

abstract：:A "pulse like" increase of cytoplasmic calcium concentration, which is proportional to ionophore concentration, is induced in red cells by exposure to A23187. Different Ca2+ levels are attained depending on cellular calcium buffering power and/or primary active calcium transport activation. We examined the effect of A...

journal_title：Physiological research

authors： Serrani RE,Gioia IA,Corchs JL

更新日期：1995-01-01 00:00:00

abstract：:Maghemite (gamma-Fe2O3) nanoparticles, 12 nm in size, were prepared by co-precipitation of Fe(II) and Fe(III) chlorides with ammonium hydroxide and oxidation with hydrogen peroxide. To achieve stability and biocompatibility, obtained particles were coated with silica, to which glucose and ascorbic acid were bound by d...

journal_title：Physiological research

authors： Moskvin M,Horák D

更新日期：2016-10-20 00:00:00

abstract：:We investigated whether polyethylene glycol-coated Fe3O4 nanoparticles (IONs), acute stress and their combination modifies vascular functions, nitric oxide synthase (NOS) activity, mean arterial pressure (MAP) as well as hepcidin and ferritin H gene expressions in Wistar-Kyoto rats. Rats were divided into control, ION...

journal_title：Physiological research

authors： Líšková S,Bališ P,Mičurová A,Kluknavský M,Okuliarová M,Puzserová A,Škrátek M,Sekaj I,Maňka J,Valovič P,Bernátová I

更新日期：2020-12-22 00:00:00

abstract：:We studied the psychophysiology of soluble intercellular adhesion molecule-1 (sICAM-1) in 25 apparently healthy middle-aged men who underwent an acute psychosocial stressor three times with one week apart. Measures of the biological stress response were obtained at week one and three. The magnitude of the sICAM-1 stre...

journal_title：Physiological research

authors： von Känel R,Preckel D,Kudielka BM,Fischer JE

更新日期：2007-01-01 00:00:00