Abstract：
:Neuroprotective effects of estrogens and progesterone have been widely studied in various experimental models. The present study was designed to compare possible neuroprotective effects of 17alpha-estradiol, 17beta-estradiol, and progesterone on oxidative stress in rats subjected to global cerebral ischemia. Global cerebral ischemia was induced in ovariectomized female rats by four vessel occlusion for 10 min. Following 72 h of reperfusion, levels of malondialdehyde (MDA, oxidative stress marker), and reduced glutathione (GSH, major endogenous antioxidant) were assessed in hippocampus, striatum and cortex of rats treated with either 17alpha-estradiol, 17beta-estradiol, progesterone or estradiol + progesterone beforehand. Steroid administration ameliorated ischemia-induced decrease in GSH and increase in MDA levels. Our data offers additional evidence that estrogens and progesterone or combination of two exert a remarkable neuroprotective effect reducing oxidative stress.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Ozacmak VH,Sayan Hsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
909-12issue
6eissn
0862-8408issn
1802-9973pii
1647journal_volume
58pub_type
杂志文章abstract：:K(+)-p-nitrophenylphosphatase (K(+)pNPPase) is the enzyme, which is considered to be involved in K(+)-dependent hydrolysis of the phosphoenzyme in the reaction cycle of Na(+), K(+)ATPase. The aim of our present study was to characterize some features of K(+)pNPPase in homogenates of the rat brain and liver. We determi...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:We studied the circadian oscillation of lipid peroxides (TBARS) in the pineal gland of rats adapted to light:dark 12:12 h regimen. The concentration of TBARS was determined at 3-h intervals during 24 hours. TBARS of pineal gland oscillated rhythmically during the 24 h period. The maximal concentration of lipoperoxidat...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:A total genome scan and pharmacogenetic study were designed to search for genetic determinants of blood pressure (BP) as well as heart and kidney weights. Genome scanning was carried out in 266 F(2) intercrosses from Prague hypertensive hypertriglyceridemic rats for phenotypes of organ weights, baseline BP, BP after b...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Pulmonary hypertension (PH) unresponsive to pharmacological intervention is considered a contraindication for orthotopic heart transplantation (OHTX) due to risk of postoperative right-heart failure. In this prospective study, we describe our experience with a treatment strategy of improving severe PH in heart transpl...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932158
更新日期：2011-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.933403
更新日期：2016-09-19 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934593
更新日期：2020-12-31 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.931768
更新日期：2010-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933947
更新日期：2019-03-06 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933366
更新日期：2017-05-04 00:00:00
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journal_title：Physiological research
pub_type： 社论
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:TGF-beta superfamily members including bone morphogenetic proteins (BMPs) and their receptors (BMPR-1A, -1B and -2) have been shown to be important for reproductive function in both males and females, while information on the role of BMPs in males is limited. Functional studies on select BMPs and BMP receptors have de...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933193
更新日期：2016-11-08 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933509
更新日期：2017-12-20 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.933392
更新日期：2016-09-19 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932086
更新日期：2011-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932841
更新日期：2015-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:The mouse kidneys are enlarged after the administration of thyroxine and this influence is not mediated through androgens. The administration of thyroxine increased the weight of the adrenals and the level of plasma corticosterone. Besides the direct effect of the thyroid hormones on the kidney, our findings indicate ...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933745
更新日期：2018-07-17 00:00:00
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journal_title：Physiological research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Familial hypercholesterolemia (FH) is most frequently caused by LDLR or APOB mutations. Therefore, the aim of our study was to examine the genetic background of Slovak patients suspected of FH. Patients with clinical suspicion of FH (235 unrelated probands and 124 family relatives) were recruited throughout Slovakia d...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933348
更新日期：2017-03-31 00:00:00
