Abstract：
:The main role of research in medicine is to provide relevant knowledge which, after successful translation to clinical practice, improves the quality of healthcare. The sex bias which is still present in the majority of research disciplines prefers male subjects despite legislation changes in the US grant agencies and European research programme Horizon 2020. Male subjects (cells, animals) still dominate in preclinical research and it has detrimental consequences for women's health and the quality of science. Opposite bias exists for data obtained mainly in animal models utilizing female subjects (e.g. research in multiple sclerosis, osteoporosis) with skewed outcomes for men affected by these diseases. Either way, scientists are producing results which compromise half of the population. Assumptions that females as cohorts are more variable and another assumption that the oestrous cycle should be tracked in case the females are enrolled in preclinical studies were proven wrong. Variability of male versus female cohorts are comparable and do not only stem from hormonal levels. The widespread prevalence of sex differences in human diseases ultimately requires detailed experiments performed on both sexes, unless the studies are specifically addressing reproduction or sex-related behaviors.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Plevkova J,Brozmanova M,Harsanyiova J,Sterusky M,Honetschlager J,Buday Tdoi
10.33549/physiolres.934593subject
Has Abstractpub_date
2020-12-31 00:00:00pages
S367-S378issue
Suppl 3eissn
0862-8408issn
1802-9973pii
934593journal_volume
69pub_type
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