Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimenta

abstract：:D-galactosamine is a hepatotoxic agent, which induces diffuse injury of liver tissue followed by the regeneration process. Our data showed a high increase of serum aminotransferases after D-galactosamine administration, which indicates a high extent of liver injury. When lipid emulsion was applied immediately after D-...

journal_title：Physiological research

authors： Ferencíková R,Cervinková Z,Drahota Z

更新日期：2003-01-01 00:00:00

abstract：:An impairment of the survival of mice subjected to whole-body gamma-irradiation with a lethal dose of 10 Gy and treated with a repeated postirradiation administration of prostaglandin synthesis inhibitors (PGSIs), indomethacin or diclofenac, was observed. Morphological examination of the gastrointestinal tract and the...

journal_title：Physiological research

authors： Hofer M,Pospísil M,Tkadlecek L,Viklická S,Pipalová I,Holá J

更新日期：1992-01-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) has been demonstrated to be implicated in disorder of insulin secretion and diabetes mellitus. In this study, we aimed to evaluate the protective role of tempol, a powerful antioxidant, in chronic intermittent hypoxia (IH)-induced pancreatic injury. The rat model of OSA was established by...

journal_title：Physiological research

authors： Wang Y,Ai L,Hai B,Cao Y,Li R,Li H,Li Y

更新日期：2019-06-30 00:00:00

abstract：:Leptin and adiponectin, two adipocytokines, may work together in regulating energy homeostasis and insulin action. Leptin gene expression has been investigated in term placental tissue complicated by gestational diabetes mellitus (GDM), but never in conjunction with all isoforms of the leptin receptor (LEPR A-D), or w...

journal_title：Physiological research

authors： Meller M,Qiu C,Vadachkoria S,Abetew DF,Luthy DA,Williams MA

更新日期：2006-01-01 00:00:00

abstract：:The effects of 8-days treatment with 17alpha-estradiol (33.3 microg/kg) and progesterone (1.7 mg/kg) on plasma lipids and fatty acid composition of plasma phospholipids were examined in intact (INT) and bilaterally common carotid arteries occluded (BCO) male Wistar rats. Significant decrease of triglyceride level was ...

journal_title：Physiological research

authors： Petrović S,Takić M,Arsić A,Vučić V,Drakulić D,Milošević M,Glibetić M

更新日期：2014-01-01 00:00:00

abstract：:Psychostimulants, including methamphetamine (MA), have neurotoxic effect, especially, if they are targeting CNS during its critical periods of development. The present study was aimed to examine cognitive changes after prenatal and neonatal MA treatment in combination with chronic MA exposure in adulthood of male rats...

journal_title：Physiological research

authors： Hrebíčková I,Ševčíková M,Nohejlová K,Šlamberová R

更新日期：2016-12-22 00:00:00

abstract：:The purpose of this study was to investigate plasma concentrations of cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) during and after real and simulated space flight. Venous blood was obtained 3 min after the beginning and 2 min after the lower body negative pressure maneuver in two cosmona...

journal_title：Physiological research

authors： Rössler A,Noskov V,László Z,Polyakow VV,Hinghofer-Szalkay HG

更新日期：2001-01-01 00:00:00

abstract：:The aim of the present study was to determine the optimal initial tension, i.e. initial stretch for rat coronary artery when using the multi-wire myograph system. We used the normalization procedure to mimic physiological conditions and to stretch the coronary arterial segments to normalized internal circumference (IC...

journal_title：Physiological research

authors： Ping NN,Cao L,Xiao X,Li S,Cao YX

更新日期：2014-01-01 00:00:00

abstract：:The paper presents an example of a new type of a structured model containing time delays in parallel branches. This model was selected as optimal to describe mathematically the lymphocyte migration between the venous blood and prescapular lymph in Merino ewes under physiological conditions. The model allowed to identi...

journal_title：Physiological research

authors： Dedík L,Durisová M,Srikusalanukul W,McCullagh P

更新日期：1999-01-01 00:00:00

abstract：:The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. ...

journal_title：Physiological research

authors： Barančík M,Grešová L,Barteková M,Dovinová I

更新日期：2016-09-19 00:00:00

abstract：:We investigated the effects of different weight loss protocols on leptin levels in obese females with the aim of addressing the leptin resistance which has been found to be an aggravating factor in obesity. Twenty-four obese females enrolled to one of three 12-week weight loss protocols: orlistat-induced weight loss (...

journal_title：Physiological research

authors： Ozcelik O,Dogan H,Celik H,Ayar A,Serhatlioglu S,Kelestimur H

更新日期：2005-01-01 00:00:00

abstract：:T-2 toxin and its metabolite HT-2 toxin are one of the most toxic mycotoxins of type A-trichothecenes, which are produced mainly by Fusarium species. Therefore, study of Fusarium toxins T-2 toxin and HT-2 toxin is an essential issue because they could also play role in failures of reproductive functions as well as end...

journal_title：Physiological research

authors： Kolesarova A,Maruniakova N,Kadasi A,Halenar M,Marak M,Sirotkin AV

更新日期：2017-09-22 00:00:00

abstract：:The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in t...

journal_title：Physiological research

authors： Ziaaldini MM,Hosseini SR,Fathi M

更新日期：2017-03-31 00:00:00

abstract：:Three-dimensional electrogram was used for analysis of ischemia manifestation in isolated hearts. Three parameters based on spherical coordination system were used in this study - amplitude of electrical heart vector, its azimuth and elevation. The parameters were presented as a trend. This approach reflected ischemic...

journal_title：Physiological research

authors： Janousek O,Kolárová J,Nováková M,Provazník I

更新日期：2010-01-01 00:00:00

abstract：:Experimental and epidemiological studies suggest that calcium intake is inversely related to weight gain. Calcium of dairy origin has been shown to be more effective in promoting weight loss. However, clinical studies yielded controversial results concerning the role of calcium intake in weight change. The aim of this...

journal_title：Physiological research

authors： Kabrnová-Hlavatá K,Hainer V,Gojová M,Hlavatý P,Kopský V,Nedvídková J,Kunesová M,Parízková J,Wagenknecht M,Hill M,Drbohlav J

更新日期：2008-01-01 00:00:00

abstract：:Ferritin and increased iron stores first appeared on the list of cardiovascular risk factors more than 30 years ago and their causal role in the pathogenesis of atherosclerosis has been heavily discussed since the early 1990s. It seems that besides traditional factors such as hyperlipoproteinemia, hypertension, diabet...

journal_title：Physiological research

authors： Kraml P

更新日期：2017-04-05 00:00:00

abstract：:Circadian oscillations in biological variables in mammals are controlled by a central pacemaker in the suprachiasmatic nuclei (SCN) of the hypothalamus which coordinates circadian oscillators in peripheral tissues. The molecular clockwork responsible for this rhythmicity consists of several clock genes and their corre...

journal_title：Physiological research

authors： Bendová Z,Sumová A

更新日期：2006-01-01 00:00:00

abstract：:Graves' disease affects approximately 3 % of women and 0.5 % of men. The first-choice therapy is based on the administration of thyrostatic drugs. However, approximately half of patients relapse within two years of discontinuation. These patients must then decide whether to re-initiate thyrostatics, which may have ser...

journal_title：Physiological research

authors： Vejrazkova D,Vcelak J,Vaclavikova E,Vankova M,Zajickova K,Duskova M,Vrbikova J,Bendlova B

更新日期：2018-11-28 00:00:00

abstract：:Gain-of-function (GOF) mutations in ion channels are rare events, which lead to increased agonist sensitivity or altered gating properties, and may render the channel constitutively active. Uncovering and following characterization of such mutants contribute substantially to the understanding of the molecular basis of...

journal_title：Physiological research

authors： Boukalova S,Touska F,Marsakova L,Hynkova A,Sura L,Chvojka S,Dittert I,Vlachova V

更新日期：2014-01-01 00:00:00

abstract：:Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and...

journal_title：Physiological research

authors： Sedivy P,Dezortova M,Drobny M,Vlasakova Z,Herynek V,Hajek M

更新日期：2018-07-17 00:00:00

abstract：:In this experiment we studied the effect of different pedalling rates during cycling at a constant power output (PO) 132+/-31 W (mean+/-S.D.), corresponding to 50% VO2 max, on the oxygen uptake and the magnitude of the slow component of VO2 kinetics in humans. The PO corresponded to 50% of VO2 max, established during ...

journal_title：Physiological research

authors： Zoladz JA,Duda K,Majerczak J

更新日期：1998-01-01 00:00:00

abstract：:In this retrospective study we analysed changes of the ST segment in patients with arterial hypertension using multi-lead body surface mapping of the electric heart field as the ST segment often shows non-specific changes and is influenced by many different conditions. We constructed isointegral maps (IIM) of chosen i...

journal_title：Physiological research

authors： Kozlíková K,Martinka J,Bulas J

更新日期：2012-01-01 00:00:00

abstract：:The influence of chronic angiotensin AT1 receptor blockade by specific antibody on the development of genetic hypertension was studied in young spontaneously hypertensive rats (SHR). The immunization of 4-week-old SHR with a small part of the angiotensin AT1 receptor molecule attenuated the development of hypertension...

journal_title：Physiological research

authors： Zelezná B,Velek J,Veselský L,Zicha J,Dobesová Z,Kunes J

更新日期：1996-01-01 00:00:00

abstract：:The gold standard material in bypass surgery of blood vessels remains the patient's own artery or vein. However, this material may be unavailable, or may suffer vein graft disease. Currently available vascular prostheses, namely polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE), per...

journal_title：Physiological research

authors： Chlupác J,Filová E,Bacáková L

更新日期：2009-01-01 00:00:00

abstract：:Epitestosterone competes with testosterone for androgen receptors and inhibits several enzymes of steroidogenesis. Insulin-like growth factors (IGFs) stimulate the growth of prostate cells and directly activate androgen receptors in prostatic tumor cell lines. The prostate-specific antigen (PSA) decreases the affinity...

journal_title：Physiological research

authors： Hill M,Bílek R,Safarík L,Stárka L

更新日期：2000-01-01 00:00:00

abstract：:Hindlimb unweighting (HU) leads to capillary regression in skeletal muscle. However, the molecular mechanism(s) remains to be elucidated. To gain insight into the regulation of this process, we investigated gene expression of hypoxia-inducible factor-1alpha (HIF-1alpha)vascular endothelial growth factor (VEGF), angiop...

journal_title：Physiological research

authors： Wagatsuma A

更新日期：2008-01-01 00:00:00

abstract：:New knowledge about the neural aspects of cough has revealed a complex network of pathways that initiate cough. The effect of inflammation on cough neural processing occurs at multiple peripheral and central sites within the nervous system. Evidence exists that direct or indirect neuroimmune interaction induces a comp...

journal_title：Physiological research

authors： Kunc P,Fabry J,Lucanska M,Zatko T,Grendar M,Pecova R

更新日期：2020-03-27 00:00:00

abstract：:The mitochondrial DNA (mtDNA) amount in cells as the basis for mitochondrial energy generating system, which produces ATP, plays an important role in the fetal development and postnatal morbidity. Isolated human cord blood leukocytes (HCBL) contribute very little to the overall metabolic turnover, but they may serve a...

journal_title：Physiological research

authors： Pejznochová M,Tesarová M,Honzík T,Hansíková H,Magner M,Zeman J

更新日期：2008-01-01 00:00:00

abstract：:Metabolic syndrome is a prevalent, complex condition. The search for genetic determinants of the syndrome is currently undergoing a paradigm enhancement by adding systems genetics approaches to association studies. We summarize the current evidence on relations between an emergent new candidate, zinc finger and BTB do...

journal_title：Physiological research

authors： Šeda O,Šedová L,Včelák J,Vaňková M,Liška F,Bendlová B

更新日期：2017-09-26 00:00:00

abstract：:It was recognized that recombinant inbred strains are a very powerful system for the study of the genetics of hypertension, linkage analysis and gene mapping. Such set of recombinant inbred strains has been developed in the cooperation of Prof V. Kren and Dr. M. Pravenec in Prague. These recombinant inbred strains wer...

journal_title：Physiological research

authors： Kunes J,Zicha J

更新日期：1993-01-01 00:00:00