Abstract：
:Impressive advances in molecular genetic techniques allow to analyze the effects of natural selection on the development of human genome. For example, the trend towards blonde hair and blue eyes was documented. The approach to analyze possible effects of natural selection on the evolution of recent phenotypes with high risk of cardiovascular disease has not been described yet. A possible effect on the evolution of two main risk factors - hypercholesterolemia and hypertension - is presented. The close relationship of non-HDL cholesterol blood concentration to the proportion of pro-inflammatory macrophages in human visceral adipose tissue might be a result of long-lasting natural selection. Individuals with higher proportion of this phenotype might also display a higher ability to fight infection, which was very common in human setting from prehistory until Middle Ages. Successful battle against infections increased the probability to survive till reproductive age. Similar hypothesis was proposed to explain frequent hypertension in African Americans. A long-lasting selection for higher ability to conserve sodium during long-term adaptation to low sodium intake and hot weather was followed by a short-term (but very hard) natural selection of individuals during transatlantic slave transport. Only those with very high capability to retain sodium were able to survive. Natural selection of phenotypes with high plasma cholesterol concentration and/or high blood pressure is recently potentiated by high-fat high-sodium diet and overnutrition. This hypothesis is also supported by the advantage of familial hypercholesterolemia in the 19th century (at the time of high infection disease mortality) in contrast to the disadvantage of familial hypercholesterolemia during the actual period of high cardiovascular disease mortality.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Poledne R,Zicha Jdoi
10.33549/physiolres.933885subject
Has Abstractpub_date
2018-05-04 00:00:00pages
155-163issue
2eissn
0862-8408issn
1802-9973pii
933885journal_volume
67pub_type
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933745
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2005-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-03-31 00:00:00
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doi：
更新日期：2001-01-01 00:00:00
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