Abstract：
:In this study we analyzed the effects of melatonin (Mel, 1 mg/kg ip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Tasset I,Medina FJ,Peña J,Jimena I,Del Carmen Muñoz M,Salcedo M,Ruiz C,Feijóo M,Montilla P,Túnez Idoi
10.33549/physiolres.931684subject
Has Abstractpub_date
2010-01-01 00:00:00pages
105-112issue
1eissn
0862-8408issn
1802-9973pii
1684journal_volume
59pub_type
杂志文章abstract：:Vascular endothelial growth factor (VEGF) has an important role in the pathogenesis of retinopathy of prematurity (ROP) and inhibition of VEGF expression in the neovascular phase might prevent destructive neovascularization in ROP. It is suggested that retinoids exert a highly potent antiangiogenic activity by inhibit...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933171
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Impressive advances in molecular genetic techniques allow to analyze the effects of natural selection on the development of human genome. For example, the trend towards blonde hair and blue eyes was documented. The approach to analyze possible effects of natural selection on the evolution of recent phenotypes with hig...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933885
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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doi：
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pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932259
更新日期：2012-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Physiological research
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doi：
更新日期：2008-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933121
更新日期：2016-07-18 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933759
更新日期：2018-07-17 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Physiological research
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doi：
更新日期：2009-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Physiological research
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doi：
更新日期：2003-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934463
更新日期：2020-07-16 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Physiological research
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934013
更新日期：2019-06-30 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934488
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