Lower omega-3 index is a marker of increased propensity of hypertensive rat heart to malignant arrhythmias.

abstract：:The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of substrates including amino acids, lipids, inorganic ions, peptides, saccharides, metals, drugs, and proteins. The ABC transporters not only move a variet...

journal_title：Physiological research

authors： Stefková J,Poledne R,Hubácek JA

更新日期：2004-01-01 00:00:00

abstract：:Steroids are important markers in pregnancy. Although estimating their levels separately in umbilical arterial (UA) and venous blood (UV) enable more precise insights into the functioning fetoplacental unit compared to using mixed umbilical blood (UM), selective aspiration of UA and UV is technically more demanding th...

journal_title：Physiological research

authors： Pašková A,Pařízek A,Hill M,Velíková M,Kubátová J,Dušková M,Adamcová K,Koucký M,Simjak P,Černý A,Stárka L

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present study was to determine the optimal initial tension, i.e. initial stretch for rat coronary artery when using the multi-wire myograph system. We used the normalization procedure to mimic physiological conditions and to stretch the coronary arterial segments to normalized internal circumference (IC...

journal_title：Physiological research

authors： Ping NN,Cao L,Xiao X,Li S,Cao YX

更新日期：2014-01-01 00:00:00

abstract：:Erythrocytes (RBC) from untrained male Wistar rats and rat glomerular endothelial cells (EC) were used to investigate the effects of acute exercise (speed: 20 m/min, slope: 0, duration: 1 hour) on RBC membrane protein oxidation and adhesion to cultured EC. Experimental animals were divided into juvenile (age 10 weeks)...

journal_title：Physiological research

authors： Temiz Artmann A,Akhisaroglu M,Sercan Z,Resmi H,Kayatekin BM,Yorukoglu K,Kirkali G

更新日期：2006-01-01 00:00:00

abstract：:Data concerning the effect of NO on the function and structure of the heart are controversial. We have studied two main questions: (i) Does the heart muscle reflect the hypertension induced by long-term inhibition of NO synthase? (ii) Since the arginine-NO pathway is also operative in the autonomic nervous system, the...

journal_title：Physiological research

authors： Gerová M,Hartmannová B,Dolezel S,Jezek L

更新日期：1996-01-01 00:00:00

abstract：:Eukaryotic cytochrome c oxidase (CcO), the terminal component of the mitochondrial electron transport chain is a heterooligomeric complex that belongs to the superfamily of heme-copper containing terminal oxidases. The enzyme, composed of both mitochondrially and nuclear encoded subunits, is embedded in the inner mito...

journal_title：Physiological research

authors： Stiburek L,Hansikova H,Tesarova M,Cerna L,Zeman J

更新日期：2006-01-01 00:00:00

abstract：:We measured plasma concentrations, adipose tissue and placental mRNA expression of hepatokines fetuin A, fetuin B and fibroblast growth factor 21 (FGF21) in 12 healthy pregnant women (P group), 12 pregnant women with gestational diabetes (GDM) and 10 healthy non-pregnant women (N group) to explore their potential role...

journal_title：Physiological research

authors： Šimják P,Cinkajzlová A,Anderlová K,Kloučková J,Kratochvílová H,Lacinová Z,Kaválková P,Krejčí H,Mráz M,Pařízek A,Kršek M,Haluzík M

更新日期：2018-11-28 00:00:00

abstract：:Oculometric behaviour assessed by pupil response provides important information about central autonomic activity and emotional regulation. However, studies regarding pupil response to emotional stimuli in adolescent depression are rare. We aimed to study emotional-linked pupil response in adolescent depression. Twenty...

journal_title：Physiological research

authors： Sekaninova N,Ondrejka I,Bona Olexova L,Visnovcova Z,Mestanik M,Cesnekova D,Hamrakova A,Tonhajzerova I

更新日期：2019-12-20 00:00:00

abstract：:The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in t...

journal_title：Physiological research

authors： Ziaaldini MM,Hosseini SR,Fathi M

更新日期：2017-03-31 00:00:00

abstract：:Homeostasis of reactive oxygen species (ROS) in cardiomyocytes is critical for elucidation of normal heart physiology and pathology. Mitochondrial phospholipases A2 (mt-PLA2) have been previously suggested to be activated by ROS. Therefore, we have attempted to elucidate physiological role of such activation. We have ...

journal_title：Physiological research

authors： Ježek J,Jabůrek M,Zelenka J,Ježek P

更新日期：2010-01-01 00:00:00

abstract：:Sensorineural hearing loss and vertigo, resulting from lesions in the sensory epithelium of the inner ear, have a high incidence worldwide. The sensory epithelium of the inner ear may exhibit extreme degeneration and is transformed to flat epithelium (FE) in humans and mice with profound sensorineural hearing loss and...

journal_title：Physiological research

authors： He L,Guo JY,Liu K,Wang GP,Gong SS

更新日期：2020-11-16 00:00:00

abstract：:The present study was performed to evaluate the role of neuronal nitric oxide synthase (nNOS)-derived nitric oxide (NO) during the developmental phase of hypertension in transgenic rats harboring the mouse Ren-2 renin gene (TGR). The first aim of the present study was to examine nNOS mRNA expression in the renal corte...

journal_title：Physiological research

authors： Cervenka L,Kramer HJ,Malý J,Vanecková I,Bäcker A,Bokemeyer D,Bader M,Ganten D,Mitchell KD

更新日期：2002-01-01 00:00:00

abstract：:Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and...

journal_title：Physiological research

authors： Sedivy P,Dezortova M,Drobny M,Vlasakova Z,Herynek V,Hajek M

更新日期：2018-07-17 00:00:00

abstract：:We developed a novel behavioral task in which rats learn to recognize the configuration of objects in an animated scene displayed on a computer screen. The scene consisted of a moving bar and a stationary rectangle. Rats deprived of food were trained to press a lever for reward in a small chamber located in front of t...

journal_title：Physiological research

authors： Nekovárová T,Klement D

更新日期：2006-01-01 00:00:00

abstract：:The aim of the study was to evaluate short-term heart rate variability (HRV) as an index of cardiac autonomic control in rats with lipopolysaccharide (LPS)-induced endotoxemia. Animals were injected intraperitoneally with LPS (100 microg/kg b.w.) and control group with an equivalent volume of saline. ECG recordings we...

journal_title：Physiological research

authors： Zila I,Mokra D,Kopincova J,Kolomaznik M,Javorka M,Calkovska A

更新日期：2015-01-01 00:00:00

abstract：:Ischemic postconditioning and remote conditioning are potentially useful tools for protecting ischemic myocardium. This study tested the hypothesis that 2,3-dehydrosilybin (DHS), a flavonolignan component of Silybum marianum, could attenuate cardiomyocyte damage following hypoxia/reoxygenation by decreasing the genera...

journal_title：Physiological research

authors： Gabrielová E,Křen V,Jabůrek M,Modrianský M

更新日期：2015-01-01 00:00:00

abstract：:Gain-of-function (GOF) mutations in ion channels are rare events, which lead to increased agonist sensitivity or altered gating properties, and may render the channel constitutively active. Uncovering and following characterization of such mutants contribute substantially to the understanding of the molecular basis of...

journal_title：Physiological research

authors： Boukalova S,Touska F,Marsakova L,Hynkova A,Sura L,Chvojka S,Dittert I,Vlachova V

更新日期：2014-01-01 00:00:00

abstract：:Neuroprotective effects of estrogens and progesterone have been widely studied in various experimental models. The present study was designed to compare possible neuroprotective effects of 17alpha-estradiol, 17beta-estradiol, and progesterone on oxidative stress in rats subjected to global cerebral ischemia. Global ce...

journal_title：Physiological research

authors： Ozacmak VH,Sayan H

更新日期：2009-01-01 00:00:00

abstract：:Sexually mature female Wistar rats were given daily intragastric doses of ethinylestradiol (EE) and levonorgestrel (LE) used normally in women: (1) 0.03 mg EE and 0.05 mg LE; (2) 0.04 mg EE and 0.075 mg LE; (3) 0.03 mg EE and 0.125 mg LE. All groups were treated for 6 months in 5-day cycles (four-day treatment with a ...

journal_title：Physiological research

authors： Nowaczyk-Dura G,Czekaj P

更新日期：1998-01-01 00:00:00

abstract：:The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. ...

journal_title：Physiological research

authors： Barančík M,Grešová L,Barteková M,Dovinová I

更新日期：2016-09-19 00:00:00

abstract：:Experiments were conducted to study the effect of goldthioglucose (GTG) upon the processes associated with lipid peroxidation. The glucose-6-phosphate dehydrogenase activity (G6PD; E.C. 1. 1.1.49) in red blood cells (RBC) and the amount of malonaldehyde precursors (MDA) per gram of brain, liver and kidney were determi...

journal_title：Physiological research

authors： Kostová D,Michnová E

更新日期：1999-01-01 00:00:00

abstract：:In the mammalian neocortex, the calcium-binding protein calretinin is expressed in a subset of cortical interneurons. In the recent years, research on interneurons is one of the most rapidly growing fields in neuroscience. This review summarizes the actual knowledge of the functions of calretinin in neuronal homeostas...

journal_title：Physiological research

authors： Barinka F,Druga R

更新日期：2010-01-01 00:00:00

abstract：:It is believed that atherogenesis is a multifactorial process, which could already start in utero. Development of atherosclerosis progresses over decades and leads to the cardiovascular morbidity and mortality in adulthood. At present, we have no exact explanation for all the risk factors acting in the pathogenesis of...

journal_title：Physiological research

authors： Szitányi P,Janda J,Poledne R

更新日期：2003-01-01 00:00:00

abstract：:Kainic acid (KA) is a potent neurotoxic substance valuable in research of temporal lobe epilepsy. We tested how subconvulsive dose of KA influences spontaneous behavior of adult Wistar rats. Animals were treated with 5 mg/kg of KA and tested in Laboras open field test for one hour in order to evaluate various behavior...

journal_title：Physiological research

authors： Riljak V,Marešová D,Pokorný J,Jandová K

更新日期：2015-01-01 00:00:00

abstract：:Autoimmune endocrinopathies can be divided according to the presence of organ specific autoantibodies and according to the clinical manifestations into isolated autoimmune endocrinopathies, autoimmune polyglandular syndromes (APS) and polyglandular activation of autoimmunity (PAA). Many factors take part in the develo...

journal_title：Physiological research

authors： Hrdá P,Sterzl I,Matucha P

更新日期：2003-01-01 00:00:00

abstract：:Growth of the A549 cell line in a perfusion system suitable for use in a magnetic resonance study has been characterized and shown to be stable physiologically and hence appropriate for serial observations. Several methods of monitoring cell growth were compared to assess the behavior of the cells in this system. Comp...

journal_title：Physiological research

authors： Shankland EG,Livesey JC,Wiseman RW,Krohn KA

更新日期：2002-01-01 00:00:00

abstract：:Methamphetamine (MA), as a psychostimulant drug that crosses the placental barrier, may disrupt the development of social play. The present study aims to examine the effect of prenatal MA (5 mg/kg) exposure during the first (gestational day (GD) 1-11) or second (GD 12-22) halves of prenatal development of rats on soci...

journal_title：Physiological research

authors： Ševčíková M,Petríková I,Šlamberová R

更新日期：2020-04-30 00:00:00

abstract：:Inflammation and other immune responses are involved in the variety of diseases and disorders. The acute response to endotoxemia includes activation of innate immune mechanisms as well as changes in autonomic nervous activity. The autonomic nervous system and the inflammatory response are intimately linked and sympath...

journal_title：Physiological research

authors： Zila I,Mokra D,Kopincova J,Kolomaznik M,Javorka M,Calkovska A

更新日期：2017-09-22 00:00:00

abstract：:The potential of novel scaffold containing sodium hyaluronate, type I collagen, and fibrin was investigated in the regeneration of osteochondral defects in miniature pigs. Both autologous chondrocyte-seeded scaffolds and non-seeded scaffolds were implanted into two defects located in the non-weight-bearing zone of the...

journal_title：Physiological research

authors： Filová E,Rampichová M,Handl M,Lytvynets A,Halouzka R,Usvald D,Hlucilová J,Procházka R,Dezortová M,Rolencová E,Kostáková E,Trc T,Stastný E,Kolácná L,Hájek M,Motlík J,Amler E

更新日期：2007-01-01 00:00:00

abstract：:Senile dementia of Alzheimer's type (AD) is commonly characterized as a neurodegenerative disorder, which exhibits gradual changes of consciousness, loss of memory, perception and orientation as well as loss of personality and intellect. AD prevalence increases dramatically with age and is the fourth cause of death in...

journal_title：Physiological research

authors： Rípová D,Strunecká A

更新日期：2001-01-01 00:00:00