Abstract：
:Data concerning the effect of NO on the function and structure of the heart are controversial. We have studied two main questions: (i) Does the heart muscle reflect the hypertension induced by long-term inhibition of NO synthase? (ii) Since the arginine-NO pathway is also operative in the autonomic nervous system, the second goal was to ascertain the possible changes of the adrenergic nervous system in the heart after long-term NO synthase inhibition. Wistar rats were administered L-NAME in drinking water (50 mg/kg bw/day) for 8 weeks. Systolic blood pressure and heart rate were monitored weekly. The heart/body weight ratio were determined at the end of experiment. The adrenergic nerve terminals visualized by histochemistry were counted according to Haug's point counting method. Blood pressure increased significantly in L-NAME-treated rats. No changes were found in the heart rate. Heart/body weight ratio increased markedly. Surprisingly, the density of adrenergic nerve terminals did not alter accordingly. The density of adrenergic nerve terminals in the left ventricle and septum decreased but no significant changes were found in the left atrium and the right ventricle. Hypertension due to NO deficiency induced cardiac hypertrophy that was characterized by a decline in the density of adrenergic innervation of the overloaded left ventricle and septum.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Gerová M,Hartmannová B,Dolezel S,Jezek Lsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
339-44issue
4eissn
0862-8408issn
1802-9973journal_volume
45pub_type
杂志文章abstract：:Parenteral nutrition-associated liver disease (PNALD) is a severe complication in patients completely dependent on parenteral nutrition (PN). The gold diagnostic standard, liver biopsy, is associated with significant health risk and therefore its use is limited. MicroRNAs (miRNAs) are small non-coding regulatory RNA m...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934103
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journal_title：Physiological research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
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doi：
更新日期：1996-01-01 00:00:00
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更新日期：2001-01-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-01-01 00:00:00
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更新日期：2002-01-01 00:00:00
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更新日期：2000-01-01 00:00:00
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更新日期：2000-01-01 00:00:00
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