Abstract：
:Vascular aging is associated with both structural and functional changes that can take place at the level of the endothelium, vascular smooth muscle cells and the extracellular matrix of blood vessels. With regard to the endothelium, reduced vasodilatation in response to agonists occurs in large conduit arteries as well as in resistance arteries with aging. Reviews concerning the different hypotheses that may account for this endothelial dysfunction have pointed out alterations in the equilibrium between endothelium-derived relaxing and constricting factors. Thus, a decreased vasorelaxation due to nitric oxide and, in some arteries, endothelium-derived hyperpolarizing factor as well as an increased vasoconstriction mediated by cyclooxygenase products such as thromboxane A2 are likely to occur in age-induced impairment of endothelial vasodilatation. Furthermore, enhanced oxidative stress plays a critical role in the deleterious effect of aging on the endothelium by means of nitric oxide breakdown due to reactive oxygen species. The relative contribution of the above phenomenon in age-related endothelial dysfunction is highly dependent on the species and type of vascular bed.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Matz RL,Schott C,Stoclet JC,Andriantsitohaina Rsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
11-8issue
1eissn
0862-8408issn
1802-9973journal_volume
49pub_type
杂志文章,评审abstract：:Exposure to hyperbaric oxygen leads to increased amount of reactive oxygen species (ROS) that are derived from various sources. After the discovery that ROS can function as signaling molecules, the idea of ROS being hazardous to biological tissues has been challenged. The aim of this study was to examine the changes i...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The Prague Hereditary Hypercholesterolemic (PHHC) rat is a model of hypercholesterolemia. In previous experiments, it was found to be completely resistant to the development of atherosclerosis. It was assumed that the reverse transport of cholesterol (RCT) might be the reason for this resistance. In this study, RCT wa...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932680
更新日期：2014-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933765
更新日期：2018-12-18 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933410
更新日期：2017-07-18 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932324
更新日期：2012-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933226
更新日期：2015-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933759
更新日期：2018-07-17 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.933403
更新日期：2016-09-19 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932611
更新日期：2014-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932599
更新日期：2013-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
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更新日期：2020-02-19 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933890
更新日期：2018-11-14 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
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更新日期：2018-11-28 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:The effects of 8-days treatment with 17alpha-estradiol (33.3 microg/kg) and progesterone (1.7 mg/kg) on plasma lipids and fatty acid composition of plasma phospholipids were examined in intact (INT) and bilaterally common carotid arteries occluded (BCO) male Wistar rats. Significant decrease of triglyceride level was ...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932590
更新日期：2014-01-01 00:00:00
abstract：:Familial hypocalciuric hypercalcemia (FHH) type 1, caused by a heterozygous inactivating mutation of the gene encoding the calcium-sensing receptor (CaSR), is characterized by mild to moderate hypercalcemia, hypocalciuria and inappropriately normal or elevated parathyroid hormone (PTH). FHH must be differentiated from...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934522
更新日期：2020-09-30 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932631
更新日期：2014-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933856
更新日期：2018-06-27 00:00:00
