Deficit of coenzyme Q in heart and liver mitochondria of rats with streptozotocin-induced diabetes.

abstract：:It is believed that atherogenesis is a multifactorial process, which could already start in utero. Development of atherosclerosis progresses over decades and leads to the cardiovascular morbidity and mortality in adulthood. At present, we have no exact explanation for all the risk factors acting in the pathogenesis of...

journal_title：Physiological research

authors： Szitányi P,Janda J,Poledne R

更新日期：2003-01-01 00:00:00

abstract：:Ultraviolet-radiation exerts a well-known role in the development of various ocular diseases and may contribute to the progress of age-related macular degeneration. Therefore, the use of compounds able to protect the eyes from UV-induced cellular damage is challenging. The aim of this study has been to test the protec...

journal_title：Physiological research

authors： Vizzarri F,Palazzo M,Bartollino S,Casamassima D,Parolini B,Troiano P,Caruso C,Costagliola C

更新日期：2018-07-17 00:00:00

abstract：:The aim of the present work was to investigate a new mechanism likely contributing to the toxic action of acetaminophen, especially to explore the possible inhibition of glutathione reductase through an acetaminophen-glutathione conjugate (APAP-SG). APAP-SG conjugate was synthesized by organic synthesis and purified b...

journal_title：Physiological research

authors： Rousar T,Pařík P,Kucera O,Bartos M,Červinková Z

更新日期：2010-01-01 00:00:00

abstract：:The present study was designed to measure interstitial levels of norepinephrine-regulating lipolysis (NE) in subcutaneous abdominal adipose tissue of anorexia nervosa (AN) patients and control subjects under basal conditions and after the local administration of an inhibitor of NE re-uptake, maprotiline. In vivo micro...

journal_title：Physiological research

authors： Nedvídková J,Dostálová I,Barták V,Papezov H,Pacák K

更新日期：2004-01-01 00:00:00

abstract：:The global epidemic of diabetes is of significant concern. Diabetes associated vascular disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also the most rapidly increasing risk factor for cognitive impairment, a silent disease that causes loss of creativity, productivity, and ...

journal_title：Physiological research

authors： Li W,Abdul Y,Ward R,Ergul A

更新日期：2018-06-27 00:00:00

abstract：:Whole blood surface tension of 15 healthy subjects recorded by the ring method was investigated in the temperature range from 20 to 40 degrees C. The surface tension omega as a function of temperature t ( degrees C) is described by an equation of linear regression as omega(t) = (-0.473 t + 70.105) x 10(-3) N/m. Blood ...

journal_title：Physiological research

authors： Rosina J,Kvasnák E,Suta D,Kolárová H,Málek J,Krajci L

更新日期：2007-01-01 00:00:00

abstract：:No data are available about the effects of AT1 receptor antagonist losartan on the skeleton and there is also little information on the activity of an ACE inhibitor enalapril on bone metabolism. It is widely believed that the vasculature plays an important role in bone remodeling under normal and pathological conditio...

journal_title：Physiological research

authors： Broulík PD,Tesar V,Zima T,Jirsa M

更新日期：2001-01-01 00:00:00

abstract：:The present review brings the survey of the most frequently used behavioural tests in experimental models of Parkinson's disease (PD). Although there is no spontaneous occurrence of parkinsonism in animals, several experimental animal models of PD have been developed to achieve the same clinical features in animals. T...

journal_title：Physiological research

authors： Mokrý J

更新日期：1995-01-01 00:00:00

abstract：:Both, common gene variants and human adenovirus 36 (Adv36) are involved in the pathogenesis of obesity. The potential relationship between these two pathogenic factors has not yet been investigated. The aim of our study was to examine the association of obesity susceptibility loci with Adv36 status. Genotyping of ten ...

journal_title：Physiological research

authors： Dušátková L,Zamrazilová H,Aldhoon Hainerová I,Atkinson RL,Sedláčková B,Lee ZP,Včelák J,Bendlová B,Kunešová M,Hainer V

更新日期：2015-01-01 00:00:00

abstract：:Hypericin is a photosensitizing plant pigment from Hypericum perforatum with multiple modes of light-induced biological activities due to production of singlet oxygen and/or excited-state proton transfer with consequent pH drop in the hypericin environment. In the present work, we studied the effects of three inhibito...

journal_title：Physiological research

authors： Mirossay A,Mirossay L,Sarisský M,Papp P,Mojzis J

更新日期：2002-01-01 00:00:00

abstract：:Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and...

journal_title：Physiological research

authors： Sedivy P,Dezortova M,Drobny M,Vlasakova Z,Herynek V,Hajek M

更新日期：2018-07-17 00:00:00

abstract：:Plant-based n-3 polyunsaturated fatty acids (PUFA) possess a prospective antiatherogenic potential. Currant oil from Ribes nigrum L. is one of the few plant oils containing PUFAn-3 (15.3 mol%) in addition to PUFAn-6 (60.5 mol%). This study was aimed at comparing the effects of currant oil with those of lard fat, rich ...

journal_title：Physiological research

authors： Vecera R,Skottová N,Vána P,Kazdová L,Chmela Z,Svagera Z,Walterá D,Ulrichová J,Simánek V

更新日期：2003-01-01 00:00:00

abstract：:Prazosin, an alpha(1)-adrenoceptor antagonist, is well known for its depressant effect on motivation and motor activity, while it has no effect on retention of spatial behavior in several tasks, e.g. in the Morris water maze and radial arm maze. The role of alpha(1)-adrenoceptors in operant tasks with stimulus-control...

journal_title：Physiological research

authors： Levčík D,Stuchlík A,Klement D

更新日期：2013-01-01 00:00:00

abstract：:We have investigated the effect of a diet containing of 4% oyster fungus (Pleurotus ostreatus) and 0.1% cholesterol on glycaemia and hyperlipoproteinaemia in rats with insulin-dependent diabetes (streptozotocin 45 mg/kg). After two months, the rats with diabetes kept on the oyster fungus diet, had a significantly lowe...

journal_title：Physiological research

authors： Chorváthová V,Bobek P,Ginter E,Klvanová J

更新日期：1993-01-01 00:00:00

abstract：:Maghemite (gamma-Fe2O3) nanoparticles, 12 nm in size, were prepared by co-precipitation of Fe(II) and Fe(III) chlorides with ammonium hydroxide and oxidation with hydrogen peroxide. To achieve stability and biocompatibility, obtained particles were coated with silica, to which glucose and ascorbic acid were bound by d...

journal_title：Physiological research

authors： Moskvin M,Horák D

更新日期：2016-10-20 00:00:00

abstract：:Male and female rats were given oestradiol benzoate (1 mg s.c. twice a week for 3 weeks) and/or sodium nitroprusside (SN), a donor of nitric oxide (NO), which was administered in their food in amounts of 0.2 or 0.6 mg/rat/day. Neither oestradiol-induced hypertrophy of the hypophysis, nor the serum prolactin (PRL) leve...

journal_title：Physiological research

authors： Nedvídková J,Schreiber V

更新日期：1992-01-01 00:00:00

abstract：:The concept of vena contracta space reduction in tricuspid valve position was tested in an animal model. Feasibility of specific artificial obturator body (REMOT) fixed to the right ventricular apex and interacting with tricuspid valve leaflets was evaluated in three different animal studies. Catheter-based technique ...

journal_title：Physiological research

authors： Sochman J,Peregrin JH,Pavcnik D,Uchida BT,Timmermans HA,Sedmera D,Benada O,Kofronova O,Keller FS,Rosch J

更新日期：2014-01-01 00:00:00

abstract：:I am pleased to introduce this special issue of Physiological Research published on the occasion of the 60th anniversary of the Institute of Physiology. It is only a second issue of this kind, the previous one being Physiological Research 53 (Suppl. 1) 2004. Since then, the Institute contributed its expertise to moder...

journal_title：Physiological research

authors： Kubínová L

更新日期：2014-01-01 00:00:00

abstract：:Levels of conjugated dienes of fatty acids (first peroxidation product) in relation to their substrates and promotors (triacylglycerols, homocysteine, iron) as well as to their inhibitors (essential antioxidative vitamins) were assessed in a vegetarian group (n=24) and compared with subjects on a mixed diet (tradition...

journal_title：Physiological research

authors： Krajcovicová-Kudlácková M,Spustová V,Pauková V

更新日期：2004-01-01 00:00:00

abstract：:We studied the response of several parameters related to oxidative stress in the liver of aging rats. Male Wistar rats aged 1.5, 3, 18 and 24 months were used. Livers showed an increase in superoxide anion (O(2)(-)) concentration at 1.5 and 18 months of age compared to the 3-month-old group; a decrease in superoxide d...

journal_title：Physiological research

authors： Mármol F,Sánchez J,López D,Martínez N,Xaus C,Peralta C,Roselló-Catafau J,Mitjavila MT,Puig-Parellada P

更新日期：2010-01-01 00:00:00

abstract：:T-2 toxin and its metabolite HT-2 toxin are one of the most toxic mycotoxins of type A-trichothecenes, which are produced mainly by Fusarium species. Therefore, study of Fusarium toxins T-2 toxin and HT-2 toxin is an essential issue because they could also play role in failures of reproductive functions as well as end...

journal_title：Physiological research

authors： Kolesarova A,Maruniakova N,Kadasi A,Halenar M,Marak M,Sirotkin AV

更新日期：2017-09-22 00:00:00

abstract：:Anthracyclines, e.g. doxorubicin, pirarubicin, are widely used as cytostatic agents in the polymer nanotherapeutics designed for the highly effective antitumor therapy with reduced side effects. However, their precise dosage scheme needs to be optimized, which requires an accurate method for their quantification on th...

journal_title：Physiological research

authors： Koziolova E,Janouskova O,Chytil P,Studenovsky M,Kostka L,Etrych T

更新日期：2015-01-01 00:00:00

abstract：:Statins are the most commonly used drugs in patients with dyslipidemia. Among the patients, a significant inter-individual variability with supposed strong genetic background in statin treatment efficacy has been observed. Genome wide screenings detected variants within the CELSR2/PSRC1/SORT1, CILP2/PBX4, APOB, APOE/C...

journal_title：Physiological research

authors： Vrablík M,Hubáček JA,Dlouhá D,Lánská V,Rynekrová J,Zlatohlávek L,Prusíková M,Ceška R,Adámková V

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to determine the effect of chronic crowding on the cardiovascular system of Wistar-Kyoto (WKY) rats. Rats were randomly divided into the control (480 cm(2) per rat) or crowded (200 cm(2) per rat) group for eight weeks. Body weight, blood pressure (BP), heart rate and plasma nitrate/nitrite le...

journal_title：Physiological research

authors： Bernátová I,Púzserová A,Navarová J,Csizmadiová Z,Zeman M

更新日期：2007-01-01 00:00:00

abstract：:Glucose tolerance, insulin binding to erythrocytes, insulinaemia, plasma total cholesterol, plasma triglycerides, weight of fat pads, food consumption and body weight changes were studied in genetically hypertensive lean Koletsky rats. Long-term treatment with dopaminergic agonist terguride (0.2 mg/kg/day) normalized ...

journal_title：Physiological research

authors： Golda V,Hilgertová J

更新日期：1997-01-01 00:00:00

abstract：:Sexually mature female Wistar rats were given daily intragastric doses of ethinylestradiol (EE) and levonorgestrel (LE) used normally in women: (1) 0.03 mg EE and 0.05 mg LE; (2) 0.04 mg EE and 0.075 mg LE; (3) 0.03 mg EE and 0.125 mg LE. All groups were treated for 6 months in 5-day cycles (four-day treatment with a ...

journal_title：Physiological research

authors： Nowaczyk-Dura G,Czekaj P

更新日期：1998-01-01 00:00:00

abstract：:Osteoporotic fractures are the result of low density and especially inferior bone quality (microarchitecture) caused by both internal (genes, hormones) and external (life style) influences. Bone mechanosensors are extremely important for the overall integrity of the skeleton, because in response to mechanical load the...

journal_title：Physiological research

authors： Zofková I

更新日期：2008-01-01 00:00:00

abstract：:Data concerning the effect of NO on the function and structure of the heart are controversial. We have studied two main questions: (i) Does the heart muscle reflect the hypertension induced by long-term inhibition of NO synthase? (ii) Since the arginine-NO pathway is also operative in the autonomic nervous system, the...

journal_title：Physiological research

authors： Gerová M,Hartmannová B,Dolezel S,Jezek L

更新日期：1996-01-01 00:00:00

abstract：:Rhythmic daily changes in the Na,K-ATPase activity have been previously described for rat kidney cortex, showing two peaks: at 0900 h and 2100 h, and two valleys: at 1500 h and 0100 h -0300 h. The oscillations in Na,K-ATPase activity are produced by an inhibitor, which binds the enzyme and is present in the rat blood ...

journal_title：Physiological research

authors： Reyes A,Galindo MM,García L,Segura-Pena D,Caruso-Neves C,Eblen-Zajjur A,Proverbio T,Marín R,Proverbio F

更新日期：2009-01-01 00:00:00

abstract：:Research and clinical implications on novel cardiac biomarkers has intensified significantly in the past few years. The high-sensitive troponin T (hscTnT) assay plays a dominant role in diagnostic algorithm regarding myocardial injury in adults. Despite generally accepted use of hscTnT there are no data about physiolo...

journal_title：Physiological research

authors： Jehlicka P,Huml M,Rajdl D,Mockova A,Matas M,Dort J,Masopustova A

更新日期：2018-05-04 00:00:00