Abstract:
:The present study was designed to measure interstitial levels of norepinephrine-regulating lipolysis (NE) in subcutaneous abdominal adipose tissue of anorexia nervosa (AN) patients and control subjects under basal conditions and after the local administration of an inhibitor of NE re-uptake, maprotiline. In vivo microdialysis technique was used to assess subcutaneous adipose NE levels in five women with AN (body mass index 14.62+/-0.47 kg/m(2)) and six age-matched controls (22.1+/-0.52 kg/m(2)). NE was assayed using high performance liquid chromatography with electrochemical detection after batch alumina extraction. Measured basal adipose tissue NE levels reflecting its interstitial levels were significantly increased in AN patients compared to the controls (106.0+/-20.9 vs. 40.0+/-5.0 pg/ml). The local maprotiline administration resulted in a significant increase in adipose tissue NE levels (AN patients: 440.0+/-28.6 vs. 202.0+/-33.0 pg/ml in the controls) in both groups. Markedly increased subcutaneous abdominal adipose tissue NE levels in AN patients compared to control subjects reflect increased sympathetic nervous system activity but not altered membrane noradrenergic transporter system in anorexia nervosa patients.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Nedvídková J,Dostálová I,Barták V,Papezov H,Pacák Ksubject
Has Abstractpub_date
2004-01-01 00:00:00pages
409-13issue
4eissn
0862-8408issn
1802-9973journal_volume
53pub_type
杂志文章abstract::We investigated how postural responses to galvanic vestibular stimulation were affected by standing on a translating support surface and by somatosensory loss due to diabetic neuropathy. We tested the hypothesis that an unstable surface and somatosensory loss can result in an increase of vestibulospinal sensitivity. B...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::We present the current state of complex circulatory dynamics model development based on Guyton's famous diagram. The aim is to provide an open-source model that will allow the simulation of a number of pathological conditions on a virtual patient including cardiac, respiratory, and kidney failure. The model will also ...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Because insulin resistance is inevitably associated with cardiovascular complications, there is a need to further investigate the potential involvement of oxidative stress and the cyclo-oxygenase (COX) pathway in the vascular modifications associated to this pathological context. Endothelial function was evaluated in ...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Reduced physical activity and abundant energy intake are two most common factors leading to uncontrolled body weight gain. But these factors are not under entire internal consciousness control; they are also partially genetically determined and are affected by for example food marketing practices. In addition to these...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
abstract::The influence of a subconvulsant dose of kainic acid (KA) on the activity of neurons was studied in the sensorimotor cortical area of urethane-anesthetized rats. A total of 41 neurons was recorded, 38 of these in layer V (probably pyramidal cells). The activity of 18 neurons was recorded before as well as more than 30...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. ...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:10.33549/physiolres.933403
更新日期:2016-09-19 00:00:00
abstract::As an autoimmune disease, type 1 diabetes mellitus (DM) can be associated with other autoimmune disorders. The aim of this study was to detect subclinically associated autoimmune thyroid disease, coeliac disease, and Addison's disease. The presence of autoantibodies was evaluated with special regard to the control of ...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Fibroblast growth factor-21 (FGF-21) has been recently characterized as a new adipokine. The aim of this study was to assess FGF-21 levels in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationship between FGF-21, disease activity and metabolic status. The levels of FGF-21 in seru...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.932324
更新日期:2012-01-01 00:00:00
abstract::The incidence of metabolic syndrome increases in the developed countries, therefore biomedical research is focused on the understanding of its etiology. The study of exact mechanisms is very complicated because both genetic and environmental factors contribute to this complex disease. The ability of environmental fact...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:10.33549/physiolres.933174
更新日期:2015-01-01 00:00:00
abstract::Inflammation and other immune responses are involved in the variety of diseases and disorders. The acute response to endotoxemia includes activation of innate immune mechanisms as well as changes in autonomic nervous activity. The autonomic nervous system and the inflammatory response are intimately linked and sympath...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:10.33549/physiolres.933671
更新日期:2017-09-22 00:00:00
abstract::This study attempted to compare the muscle fiber morphological responses to dynamic electrical muscle stimulation (DEMS) and dynamic hydraulic stimulation (DHS) in rats under hindlimb suspension (HLS). DEMS at 1 Hz, 50 Hz and 100 Hz for 10 min/day, 5 days/week were introduced to the animals' right quadriceps. Static a...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.933101
更新日期:2017-07-18 00:00:00
abstract::The aim of this study was to assess the molecular basis of renal Na,K-ATPase disturbances in response to NO-deficient hypertension induced in rats by NO-synthase inhibition with 40 mg/kg/day N(G)-nitro-L-arginine methyl ester (L-NAME) for four weeks. After 4-week administration of L-NAME, the systolic blood pressure (...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The aim of this study was to determine the effect of chronic crowding on the cardiovascular system of Wistar-Kyoto (WKY) rats. Rats were randomly divided into the control (480 cm(2) per rat) or crowded (200 cm(2) per rat) group for eight weeks. Body weight, blood pressure (BP), heart rate and plasma nitrate/nitrite le...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::The administration of a diet containing 5% of dried oyster mushroom to male Wistar rats fed a cholesterol diet (0.3%) shortly after weaning for 8 weeks reduced cholesterol levels in the serum and liver by 27 and 33%, respectively and increased the fractional turnover rate of 125I-very-low-density lipoproteins (VLDL) b...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The global epidemic of diabetes is of significant concern. Diabetes associated vascular disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also the most rapidly increasing risk factor for cognitive impairment, a silent disease that causes loss of creativity, productivity, and ...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:10.33549/physiolres.933833
更新日期:2018-06-27 00:00:00
abstract::An important mechanism underlying cochlear hair cell (HC) susceptibility to hypoxia/ischemia is the influx of Ca(2+). Two main ATP-dependent mechanisms contribute to maintaining low Ca(2+) levels: uptake of Ca(2+) into intracellular stores via smooth endoplasmic reticulum calcium ATPase (SERCA) and extrusion of Ca(2+)...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::This study was undertaken to investigate the effects of lower body positive pressure (LBPP) on cardiovascular responses during a 15-min walking trial in young (22.1+/-0.4 years) and elderly women (67.8+/-1.1 years). The application of 20 mm Hg LBPP reduced ground reaction forces by 31.2+/-0.5 kgw in both groups. We hy...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.932459
更新日期:2013-01-01 00:00:00
abstract::Hemodynamics in the distal end-to-side anastomosis is related to early development of intimal hyperplasia and bypass failure. In this study we investigated the effect of diameter ratios between the target artery and the bypass at three different angles of the connection. The pulsatile flow field was visualized using p...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.933297
更新日期:2016-12-13 00:00:00
abstract::At present, there are insufficient information about baroreflex sensitivity (BRS) and factors that determine BRS in premature newborns. The objective of this study was to determine the relationship between BRS and the characteristics that reflecting the intrauterine development (gestational age and birth weight), as w...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.933681
更新日期:2017-09-22 00:00:00
abstract::Cough is one of the most important defensive reflexes. However, extensive non- productive cough is a harmful mechanism leading to the damage of human airways. Cough is initiated by activation of vagal afferents in the airways. The site of their convergence is particularly the nucleus of the solitary tract (nTS). The s...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:10.33549/physiolres.934400
更新日期:2020-03-27 00:00:00
abstract::Differential pulse voltammetry with a carbon fibre microelectrode (ME) was used in pentobarbital-anaesthetized rats for monitoring the stobadine current (STB.C) on both sides of the blood-brain barrier (BBB) in the arterial bloodstream (BS) and in the corpus striatum (CS). The STB.C exhibited a distinct peak at a pola...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The circadian rhythms of many behavioral and physiological functions are regulated by the major circadian pacemaker in the suprachiasmatic nucleus. Long-term opiate addiction and drug withdrawal may affect circadian rhythmicity of various hormones or the sleep/activity pattern of many experimental subjects; however, l...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.933183
更新日期:2016-07-18 00:00:00
abstract::In this study we compared several parameters characterizing differences in the lipoprotein profile between members of families with a positive or negative family history of coronary artery disease (CAD). In addition to regular parameters such as the body mass index (BMI), total plasma cholesterol (TC), low density (LD...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Male rats aged 45, 85, 145 and 270 days (daily body mass increments on an optimal diet containing casein were 6.73, 2.88, 0.53 and 0.31 g respectively) were fed 15 days ad libitum on a diet with a nutrient content physiological for their age, in which the protein source was milk casein (ratio of essential to nonessent...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::During 48 hours after application sublethal doses of hepatotoxic agent thiacetamide decrease cytochrome c oxidase activity of rat liver homogenate and isolated mitochondria to 46% and 32% of original values, respectively. This decrease may be prevented by simultaneous application of lipid emulsion (mixture of Lipofund...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Obstructive sleep apnea (OSA) has been demonstrated to be implicated in disorder of insulin secretion and diabetes mellitus. In this study, we aimed to evaluate the protective role of tempol, a powerful antioxidant, in chronic intermittent hypoxia (IH)-induced pancreatic injury. The rat model of OSA was established by...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.934010
更新日期:2019-06-30 00:00:00
abstract::Heart failure has become the most widely studied syndrome in cardiology over the recent years. Despite the encouraging achievements by angiotensin converting enzyme (ACE) inhibitors, the mortality of patients with chronic heart failure remains high. There are several factors which can potentially be responsible for th...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::This study was designed primarily to identify relationships among indices of muscle tissue structure (m. vastus lateralis) and of somatic qualities (anthropometric parameters) in 44 untrained men and 105 well-trained athletes. The ratio of glycolytic to oxidative muscle fibres was significantly less (P < 0.05) in endu...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Three-dimensional electrogram was used for analysis of ischemia manifestation in isolated hearts. Three parameters based on spherical coordination system were used in this study - amplitude of electrical heart vector, its azimuth and elevation. The parameters were presented as a trend. This approach reflected ischemic...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:
更新日期:2010-01-01 00:00:00
abstract::To compare serum adiponectin changes across the menstrual cycle between normal weight and overweight/obese young women and its correlation with serum estradiol. Young women (n=56) with regular menstrual cycle had been grouped according to their BMI into normal weight group (n=26) and overweight /obese group (n=30). Bl...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.934197
更新日期:2019-12-30 00:00:00