Abstract：
:We present the current state of complex circulatory dynamics model development based on Guyton's famous diagram. The aim is to provide an open-source model that will allow the simulation of a number of pathological conditions on a virtual patient including cardiac, respiratory, and kidney failure. The model will also simulate the therapeutic influence of various drugs, infusions of electrolytes, blood transfusion, etc. As a current result of implementation, we describe a core model of human physiology targeting the systemic circulation, arterial pressure and body fluid regulation, including short- and long-term regulations. The model can be used for educational purposes and general reflection on physiological regulation in pathogenesis of various diseases.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Kofránek J,Rusz Jsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
897-908issue
6eissn
0862-8408issn
1802-9973pii
931838journal_volume
59pub_type
杂志文章abstract：:The present study investigated the effects of head cooling during endurance cycling on performance and the serotonergic neuroendocrine response to exercise in the heat. Subjects exercised at 75 % VO(2max) to volitional fatigue on a cycle ergometer at an ambient temperature of 29+/-1.0 degrees C, with a relative humidi...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Physiological research
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doi：
更新日期：2009-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章
doi：10.33549/physiolres.933348
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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doi：
更新日期：1999-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章
doi：10.33549/physiolres.932380
更新日期：2013-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932580
更新日期：2014-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934010
更新日期：2019-06-30 00:00:00
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更新日期：2014-01-01 00:00:00
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pub_type： 杂志文章
doi：10.33549/physiolres.932793
更新日期：2015-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933297
更新日期：2016-12-13 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933350
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934127
更新日期：2019-10-25 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.933174
更新日期：2015-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
abstract：:Gastrointestinal hormones play an important role in the neuroendocrine regulation of food intake and postprandial satiety. Ghrelin is a 28-amino acid orexigenic peptide produced mainly by the stomach that is involved in both the long-term regulation of body weight and the short-term regulation of postprandial satiety....
journal_title：Physiological research
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doi：
更新日期：2009-01-01 00:00:00
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doi：
更新日期：2007-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
