The molecular genetic background of familial hypercholesterolemia: data from the Slovak nation-wide survey.

abstract：:The left and right ventricle originate from distinct parts of the cardiac tube, and several genes are known to be differentially expressed in these compartments. The aims of this study were to determine developmental differences in gene expression between the left and right ventricle, and to assess the effect of alter...

journal_title：Physiological research

authors： Krejčí E,Pesevski Z,DeAlmeida AC,Mrug M,Fresco VM,Argraves WS,Barth JL,Cui X,Sedmera D

更新日期：2012-01-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) and polycystic ovary syndrome (PCOS) are distinct pathologies with impaired insulin sensitivity as a common feature. The aim of this study was to evaluate the response of fat tissue adipokines and gastrointestinal incretins to glucose load in patients diagnosed with one of the two d...

journal_title：Physiological research

authors： Vejrazkova D,Lischkova O,Vankova M,Stanicka S,Vrbikova J,Lukasova P,Vcelak J,Vacinova G,Bendlova B

更新日期：2017-05-04 00:00:00

abstract：:The haemolytic action of HgCl2 (0, 15 mmol.l-1) was studied in relation to the ionic strength and concentration of glucose and saccharose in incubating medium. Blood from 94 donors, aged 19-46 years were used in our experiments. In relation to the ionic strength the haemolytic action was characteristic with two maxima...

journal_title：Physiological research

authors： Nicák A,Mojzis J

更新日期：1992-01-01 00:00:00

abstract：:The most common etiology of non-syndromic monogenic obesity are mutations in gene for the Melanocortin-4 receptor (MC485) with variable prevalence in different countries (1.2-6.3 % of obese children). The aim of our study was 1) to search for MC4R mutations in obese children in Slovakia and compare their prevalence wi...

journal_title：Physiological research

authors： Stanikova D,Surova M,Ticha L,Petrasova M,Virgova D,Huckova M,Skopkova M,Lobotkova D,Valentinova L,Mokan M,Stanik J,Klimes I,Gasperikova D

更新日期：2015-01-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) therapy, i.e. breathing pure oxygen under increased environmental pressures serves as a treatment for diverse medical conditions. However, elevated oxygen concentration can be detrimental to central nervous system or lungs. Our study aimed to evaluate the effects of repeated exposure to HBO on ...

journal_title：Physiological research

authors： Dejmek J,Kohoutová M,Kripnerová M,Čedíková M,Tůma Z,Babuška V,Bolek L,Kuncová J

更新日期：2018-12-31 00:00:00

abstract：:Clusterin is a heterodimeric glycoprotein with wide range of functions. To further explore its possible regulatory role in energy homeostasis and in adipose tissue, we measured plasma clusterin and its mRNA expression in subcutaneous adipose tissue (SCAT) of 15 healthy lean women, 15 obese women (OB) and 15 obese wome...

journal_title：Physiological research

authors： Kloučková J,Lacinová Z,Kaválková P,Trachta P,Kasalický M,Haluzíková D,Mráz M,Haluzík M

更新日期：2016-07-18 00:00:00

abstract：:Epitestosterone competes with testosterone for androgen receptors and inhibits several enzymes of steroidogenesis. Insulin-like growth factors (IGFs) stimulate the growth of prostate cells and directly activate androgen receptors in prostatic tumor cell lines. The prostate-specific antigen (PSA) decreases the affinity...

journal_title：Physiological research

authors： Hill M,Bílek R,Safarík L,Stárka L

更新日期：2000-01-01 00:00:00

abstract：:Resveratrol, which is a polyphenol present in red wines and vegetables included in human diets, exerts many biological effects. The aim of the present study was to investigate its effect on some activities of polymorphonuclear leukocytes, particularly the generation of superoxide anion ((O2)(-)) in whole blood, hypoch...

journal_title：Physiological research

authors： Cavallaro A,Ainis T,Bottari C,Fimiani V

更新日期：2003-01-01 00:00:00

abstract：:The microcirculation, like all physiological systems undergoes modifications during the course of pregnancy. These changes aid the adaption to the new anatomical and physiological environment of pregnancy and ensure adequate oxygen supply to the fetus. Even though the microcirculation is believed to be involved in maj...

journal_title：Physiological research

authors： Abdo I,George RB,Farrag M,Cerny V,Lehmann C

更新日期：2014-01-01 00:00:00

abstract：:This study was designated to estimate protective role of ETA and ETB receptor antagonist against endothelin 1 (ET-1)-induced oxidative stress in lungs and determine whether these effects are mediated by nitric oxide (NO) synthase. Experiments were performed on Wistar rats divided into the following groups: I - saline ...

journal_title：Physiological research

authors： Kleniewska P,Gorąca A

更新日期：2016-11-23 00:00:00

abstract：:Precise and efficient endocytosis is critical for sustained neurotransmission during continuous neuronal activity. Endocytosis is a prerequisite for maintaining the auditory function. However, the differences between the patterns of endocytosis in cochlear inner hair cells (IHCs) and outer hair cells (OHCs) remain unc...

journal_title：Physiological research

authors： Li S,Yu S,Ding T,Yan A,Qi Y,Gong S,Tang S,Liu K

更新日期：2019-08-29 00:00:00

abstract：:The mood and behavior of individuals result from an orchestra of many factors. Among them steroids play an important role; however, only several common hormones have been investigated in this respect. It has been demonstrated that some steroid metabolites long considered merely the products of steroid hormone metaboli...

journal_title：Physiological research

authors： Dušková M,Hill M,Bičíková M,Šrámková M,Řípová D,Mohr P,Stárka L

更新日期：2015-01-01 00:00:00

abstract：:Primary aldosteronism (PA) is the most common cause of endocrine hypertension with a high frequency of cardiovascular complications. The unfavorable cardiometabolic profile may be due to aldosterone-mediated activation of inflammatory cells, circulatory cytokines and activation of collagen synthesis in the vessel wall...

journal_title：Physiological research

authors： Šomlóová Z,Petrák O,Rosa J,Štrauch B,Indra T,Zelinka T,Haluzík M,Zikán V,Holaj R,Widimský J Jr

更新日期：2016-06-20 00:00:00

abstract：:Hypersensitive pain response is observed in patients with Parkinson's disease (PD). However, the signal pathways leading to hyperalgesia still need to be clarified. Chronic oxidative stress is one of the hallmarks of PD pathophysiology. Since the midbrain periaqueductal gray (PAG) is an important component of the desc...

journal_title：Physiological research

authors： Zhang W,Sun L,Yang X,Wang R,Wang H

更新日期：2020-08-31 00:00:00

abstract：:The goal of this study was to identify small molecular weight compounds that bind to sclerostin using in-silico methods because of the established importance of sclerostin-based therapies for the treatment of disease characterized by low bone mass. The zinc database (Zdb) revealed that nine potential molecules bind to...

journal_title：Physiological research

authors： Muthusamy K,Mohan S,Nagamani S,Kesavan C

更新日期：2016-11-23 00:00:00

abstract：:Levels of conjugated dienes of fatty acids (first peroxidation product) in relation to their substrates and promotors (triacylglycerols, homocysteine, iron) as well as to their inhibitors (essential antioxidative vitamins) were assessed in a vegetarian group (n=24) and compared with subjects on a mixed diet (tradition...

journal_title：Physiological research

authors： Krajcovicová-Kudlácková M,Spustová V,Pauková V

更新日期：2004-01-01 00:00:00

abstract：:Sensorineural hearing loss and vertigo, resulting from lesions in the sensory epithelium of the inner ear, have a high incidence worldwide. The sensory epithelium of the inner ear may exhibit extreme degeneration and is transformed to flat epithelium (FE) in humans and mice with profound sensorineural hearing loss and...

journal_title：Physiological research

authors： He L,Guo JY,Liu K,Wang GP,Gong SS

更新日期：2020-11-16 00:00:00

abstract：:The present study evaluates the protective role of Quercetin (Quer), against immobilization stress- induced anxiety, depression and cognition alteration in mice using behavioral and biochemical parameters. 24 adult Albino mice were distributed into 2 groups vehicle (n=12; 1 ml/kg) and Quer injected (n=12; 20 mg/kg/ml)...

journal_title：Physiological research

authors： Samad N,Saleem A,Yasmin F,Shehzad MA

更新日期：2018-11-14 00:00:00

abstract：:We investigated the effects of different weight loss protocols on leptin levels in obese females with the aim of addressing the leptin resistance which has been found to be an aggravating factor in obesity. Twenty-four obese females enrolled to one of three 12-week weight loss protocols: orlistat-induced weight loss (...

journal_title：Physiological research

authors： Ozcelik O,Dogan H,Celik H,Ayar A,Serhatlioglu S,Kelestimur H

更新日期：2005-01-01 00:00:00

abstract：:The concept of vena contracta space reduction in tricuspid valve position was tested in an animal model. Feasibility of specific artificial obturator body (REMOT) fixed to the right ventricular apex and interacting with tricuspid valve leaflets was evaluated in three different animal studies. Catheter-based technique ...

journal_title：Physiological research

authors： Sochman J,Peregrin JH,Pavcnik D,Uchida BT,Timmermans HA,Sedmera D,Benada O,Kofronova O,Keller FS,Rosch J

更新日期：2014-01-01 00:00:00

abstract：:Statins are the most commonly used drugs in patients with dyslipidemia. Among the patients, a significant inter-individual variability with supposed strong genetic background in statin treatment efficacy has been observed. Genome wide screenings detected variants within the CELSR2/PSRC1/SORT1, CILP2/PBX4, APOB, APOE/C...

journal_title：Physiological research

authors： Vrablík M,Hubáček JA,Dlouhá D,Lánská V,Rynekrová J,Zlatohlávek L,Prusíková M,Ceška R,Adámková V

更新日期：2012-01-01 00:00:00

abstract：:Insulin is known to increase blood flow in parallel to glucose uptake in skeletal muscle. However, it is not known if an increase in blood flow by itself is associated with an increase in glucose uptake in the absence of hyperinsulinemia. To investigate further this matter, the effect of increased blood flow on forear...

journal_title：Physiological research

authors： Sarabi M,Lind L,Millgard J,Hänni A,Hägg A,Berne C,Lithell H

更新日期：1999-01-01 00:00:00

abstract：:Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their level...

journal_title：Physiological research

authors： Cibičková Ľ,Langová K,Vaverková H,Kubíčková V,Karásek D

更新日期：2017-07-18 00:00:00

abstract：:Hindlimb unweighting (HU) leads to capillary regression in skeletal muscle. However, the molecular mechanism(s) remains to be elucidated. To gain insight into the regulation of this process, we investigated gene expression of hypoxia-inducible factor-1alpha (HIF-1alpha)vascular endothelial growth factor (VEGF), angiop...

journal_title：Physiological research

authors： Wagatsuma A

更新日期：2008-01-01 00:00:00

abstract：:Impaired cerebrovascular reactivity (CVR), an important risk factor for future stroke, is affected by a presence carotid stenosis. However, in some cases CVR can be impaired in the absence of carotid stenosis due to several poorly characterized mechanisms. We hypothesized that arterial stiffening as observed in corona...

journal_title：Physiological research

authors： Rucka D,Marek J,Rucklova Z,Lubanda JC,Havranek S,Skvaril J,Varejka P,Chochola M,Karetova D,Korinek J,Linhart A

更新日期：2015-01-01 00:00:00

abstract：:Ferritin and increased iron stores first appeared on the list of cardiovascular risk factors more than 30 years ago and their causal role in the pathogenesis of atherosclerosis has been heavily discussed since the early 1990s. It seems that besides traditional factors such as hyperlipoproteinemia, hypertension, diabet...

journal_title：Physiological research

authors： Kraml P

更新日期：2017-04-05 00:00:00

abstract：:The aim of the present study was to compare the oscillations of oxygenation in skeletal muscle between early and late phases in prolonged exercise. During prolonged exercise at 60 % of peak oxygen uptake (V(.)o(2)) for 60 min and at rest, oxygenated hemoglobin/myoglobin (Hb/MbO(2)) and total Hb/Mb (THb/Mb) were determ...

journal_title：Physiological research

authors： Yano T,Lian CS,Arimitsu T,Yamanaka R,Afroundeh R,Shirakawa K,Yunoki T

更新日期：2013-01-01 00:00:00

abstract：:Hepcidin is a key regulator of iron metabolism and plays an important role in many pathologies. It is increased by iron administration and by inflammation, while erythropoiesis downregulates its expression. It decreases iron availability and thus contributes to anemia of chronic diseases. The aim of the study was to m...

journal_title：Physiological research

authors： Přikryl P,Hrušková Z,Konopásek P,Hladinová Z,Tesař V,Vokurka M

更新日期：2018-12-18 00:00:00

abstract：:We performed a systematic study to check whether neurons in the area TE (the anterior part of inferotemporal cortex) in rhesus monkey, regarded as the last stage of the ventral visual pathway, could be modulated by auditory stimuli. Two fixating rhesus monkeys were presented with visual, auditory or combined audiovisu...

journal_title：Physiological research

authors： Kaposvári P,Csibri P,Csete G,Tompa T,Sáry G

更新日期：2011-01-01 00:00:00

abstract：:Atrial fibrillation is associated with atrial remodeling, in which connexin 43 (Cx43) and cell hypertrophy play important roles. In this study, apelin-13, an aliphatic peptide, was used to explore the protective effects of the adenosine monophosphate-activated protein kinase (AMPK)/mTOR signaling pathway on Cx43 expre...

journal_title：Physiological research

authors： Chen Y,Qiao X,Zhang L,Li X,Liu Q

更新日期：2020-11-16 00:00:00