Abstract：
:Resveratrol, which is a polyphenol present in red wines and vegetables included in human diets, exerts many biological effects. The aim of the present study was to investigate its effect on some activities of polymorphonuclear leukocytes, particularly the generation of superoxide anion ((O2)(-)) in whole blood, hypochlorous acid (HOCl) and nitric oxide (NO) production by isolated cells, and chemotaxis. Resveratrol showed significant dose-dependent inhibitory effect on all these activities. In particular, it inhibited O2(-) generation in stimulated but not in resting neutrophils, decreased HOCl much more than O2(-) production indicating an effect on myeloperoxidase secretion since HOCl production is directly and proportionally dependent on O2(-) generation and reduced cell motility. The small dose of resveratrol (4.38 nM) used is attainable with a diet including red wine and vegetables confirming its protective role against some pathological processes such as inflammation, coronary heart disease, and cancer.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Cavallaro A,Ainis T,Bottari C,Fimiani Vsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
555-62issue
5eissn
0862-8408issn
1802-9973journal_volume
52pub_type
杂志文章abstract：:The effects of selenium (Se) on antioxidant defense system in liver and kidneys of rats with cadmium (Cd)-induced toxicity were examined. Cd exposure (15 mg Cd/kg b.m./day as CdCl(2) for 4 weeks) resulted in increased lipid peroxidation (LP) in both organs (p<0.005 and p<0.01). Vitamin C (Vit C) was decreased in the l...
journal_title：Physiological research
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doi：
更新日期：2008-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.33549/physiolres.933392
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journal_title：Physiological research
pub_type： 杂志文章,评审
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journal_title：Physiological research
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更新日期：2007-01-01 00:00:00
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journal_title：Physiological research
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doi：
更新日期：2002-01-01 00:00:00
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journal_title：Physiological research
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doi：
更新日期：2010-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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doi：
更新日期：2006-01-01 00:00:00
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更新日期：2019-12-20 00:00:00
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journal_title：Physiological research
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doi：
更新日期：2005-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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doi：
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pub_type： 杂志文章,评审
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更新日期：1999-01-01 00:00:00
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journal_title：Physiological research
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更新日期：2008-01-01 00:00:00
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