Abstract:
:Metabolic syndrome is a prevalent, complex condition. The search for genetic determinants of the syndrome is currently undergoing a paradigm enhancement by adding systems genetics approaches to association studies. We summarize the current evidence on relations between an emergent new candidate, zinc finger and BTB domain containing 16 (ZBTB16) transcription factor and the major components constituting the metabolic syndrome. Information stemming from studies on experimental models with altered Zbtb16 expression clearly shows its effect on adipogenesis, cardiac hypertrophy and fibrosis, lipid levels and insulin sensitivity. Based on current evidence, we provide a network view of relations between ZBTB16 and hallmarks of metabolic syndrome in order to elucidate the potential functional links involving the ZBTB16 node. Many of the identified genes interconnecting ZBTB16 with all or most metabolic syndrome components are linked to immune function, inflammation or oxidative stress. In summary, ZBTB16 represents a promising pleiotropic candidate node for metabolic syndrome.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Šeda O,Šedová L,Včelák J,Vaňková M,Liška F,Bendlová Bdoi
10.33549/physiolres.933730subject
Has Abstractpub_date
2017-09-26 00:00:00pages
S357-S365issue
Suppl 3eissn
0862-8408issn
1802-9973pii
933730journal_volume
66pub_type
杂志文章,评审abstract::Male rats aged 45, 85, 145 and 270 days (daily body mass increments on an optimal diet containing casein were 6.73, 2.88, 0.53 and 0.31 g respectively) were fed 15 days ad libitum on a diet with a nutrient content physiological for their age, in which the protein source was milk casein (ratio of essential to nonessent...
journal_title:Physiological research
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journal_title:Physiological research
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journal_title:Physiological research
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.33549/physiolres.932793
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
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