Identification of novel small molecules that bind to the loop2 region of sclerostin - an in silico computational analysis.

abstract：:Perinatal hypoxemia may have serious long-term effects on the adult cardiovascular system and may lead to sex-dependent changes in cardiac tolerance to acute ischemia in adult life. The aim of the study was to answer the question whether gonadectomy of the male and female rats in the early phase of ontogenetic develop...

journal_title：Physiological research

authors： Netuka I,Szárszoi O,Malý J,Říha H,Turek D,Ostádalová I,Ostádal B

更新日期：2010-01-01 00:00:00

abstract：:At present, there are insufficient information about baroreflex sensitivity (BRS) and factors that determine BRS in premature newborns. The objective of this study was to determine the relationship between BRS and the characteristics that reflecting the intrauterine development (gestational age and birth weight), as w...

journal_title：Physiological research

authors： Haskova K,Javorka M,Czippelova B,Zibolen M,Javorka K

更新日期：2017-09-22 00:00:00

abstract：:We investigated whether polyethylene glycol-coated Fe3O4 nanoparticles (IONs), acute stress and their combination modifies vascular functions, nitric oxide synthase (NOS) activity, mean arterial pressure (MAP) as well as hepcidin and ferritin H gene expressions in Wistar-Kyoto rats. Rats were divided into control, ION...

journal_title：Physiological research

authors： Líšková S,Bališ P,Mičurová A,Kluknavský M,Okuliarová M,Puzserová A,Škrátek M,Sekaj I,Maňka J,Valovič P,Bernátová I

更新日期：2020-12-22 00:00:00

abstract：:Our previous studies concerning the role of furosemide-resistant cation leaks in genetic hypertension demonstrated that blood pressure of recombinant inbred strains (derived from F2 hybrids of spontaneously hypertensive and normotensive Brown Norway rats) cosegregated with inward Na+ leak (determined in saline medium)...

journal_title：Physiological research

authors： Bin Talib HK,Zicha J

更新日期：1993-01-01 00:00:00

abstract：:Inhibition of receptor-interacting serine/threonine-protein kinase 1 (RIP1) by necrostatin-1 (Nec-1) alleviates cardiac injury due to prevention of necroptotic cell death. Its inactive analogue necrostatin-1i (Nec-1i), lacking RIP1 activity, serves as a suitable control. It is unknown if these agents influence the hea...

journal_title：Physiological research

authors： Szobi A,Rajtik T,Adameova A

更新日期：2016-11-23 00:00:00

abstract：:Electrophysiological studies of whole organ systems in vitro often require measurement of nerve activity and/or stimulation of the organ via the associated nerves. Currently two-compartment setups are used for such studies. These setups are complicated and require two fluids in two separate compartments and stretching...

journal_title：Physiological research

authors： Choudhary M,Clavica F,van Mastrigt R,van Asselt E

更新日期：2016-06-20 00:00:00

abstract：:Cough is one of the most important defensive reflexes. However, extensive non- productive cough is a harmful mechanism leading to the damage of human airways. Cough is initiated by activation of vagal afferents in the airways. The site of their convergence is particularly the nucleus of the solitary tract (nTS). The s...

journal_title：Physiological research

authors： Lucanska M,Hajtman A,Calkovsky V,Kunc P,Pecova R

更新日期：2020-03-27 00:00:00

abstract：:The most common etiology of non-syndromic monogenic obesity are mutations in gene for the Melanocortin-4 receptor (MC485) with variable prevalence in different countries (1.2-6.3 % of obese children). The aim of our study was 1) to search for MC4R mutations in obese children in Slovakia and compare their prevalence wi...

journal_title：Physiological research

authors： Stanikova D,Surova M,Ticha L,Petrasova M,Virgova D,Huckova M,Skopkova M,Lobotkova D,Valentinova L,Mokan M,Stanik J,Klimes I,Gasperikova D

更新日期：2015-01-01 00:00:00

abstract：:Sensorineural hearing loss and vertigo, resulting from lesions in the sensory epithelium of the inner ear, have a high incidence worldwide. The sensory epithelium of the inner ear may exhibit extreme degeneration and is transformed to flat epithelium (FE) in humans and mice with profound sensorineural hearing loss and...

journal_title：Physiological research

authors： He L,Guo JY,Liu K,Wang GP,Gong SS

更新日期：2020-11-16 00:00:00

abstract：:Instead of a comprehensive review, we describe the basic undisputed facts and a modest contribution of our group to the fascinating area of the research on mitochondrial uncoupling proteins. After defining the terms uncoupling, leak, protein-mediated uncoupling, we discuss the assumption that due to their low abundanc...

journal_title：Physiological research

authors： Jezek P,Zácková M,Růzicka M,Skobisová E,Jabůrek M

更新日期：2004-01-01 00:00:00

abstract：:Prazosin, an alpha(1)-adrenoceptor antagonist, is well known for its depressant effect on motivation and motor activity, while it has no effect on retention of spatial behavior in several tasks, e.g. in the Morris water maze and radial arm maze. The role of alpha(1)-adrenoceptors in operant tasks with stimulus-control...

journal_title：Physiological research

authors： Levčík D,Stuchlík A,Klement D

更新日期：2013-01-01 00:00:00

abstract：:The organization of the neocortical projection to the inferior colliculus (IC) was studied in 36 rats using retrograde transport of horseradish peroxidase (HRP) or horseradish peroxidase conjugated with lectin (WGA-HRP). Projection to the external and dorsal cortices originates in the temporal neocortical areas Te 1, ...

journal_title：Physiological research

authors： Druga R,Syka J,Rajkowska G

更新日期：1997-01-01 00:00:00

abstract：:In this experiment we studied the effect of different pedalling rates during cycling at a constant power output (PO) 132+/-31 W (mean+/-S.D.), corresponding to 50% VO2 max, on the oxygen uptake and the magnitude of the slow component of VO2 kinetics in humans. The PO corresponded to 50% of VO2 max, established during ...

journal_title：Physiological research

authors： Zoladz JA,Duda K,Majerczak J

更新日期：1998-01-01 00:00:00

abstract：:Hepcidin is a key regulator of iron metabolism and plays an important role in many pathologies. It is increased by iron administration and by inflammation, while erythropoiesis downregulates its expression. It decreases iron availability and thus contributes to anemia of chronic diseases. The aim of the study was to m...

journal_title：Physiological research

authors： Přikryl P,Hrušková Z,Konopásek P,Hladinová Z,Tesař V,Vokurka M

更新日期：2018-12-18 00:00:00

abstract：:To compare circulating pigment epithelium derived factor (PEDF) levels in type 2 diabetes patients (T2D) with and without metabolic syndrome (MetS+/-) to healthy controls and assess PEDF association with plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF) as markers of endothelial dysfunction. Fi...

journal_title：Physiological research

authors： Karasek D,Spurna J,Kubickova V,Krystynik O,Cibickova L,Schovanek J,Goldmannova D

更新日期：2019-06-30 00:00:00

abstract：:We investigated the influence of oxygenation of in vitro lung preparation on the pulmonary vascular reactivity. Small pulmonary vessels isolated from adult male Wistar rats exposed for 4 days to hypoxia (F(iO2) = 0.1, group CH) were compared with those of normoxic controls (group N). The bath in the chamber of small v...

journal_title：Physiological research

authors： Zaloudíková M,Vízek M,Herget J

更新日期：2009-01-01 00:00:00

abstract：:We analyzed the effect of FK 506 on the production of nitric oxide by macrophages. Isolated rat peritoneal macrophages were cultured for 24 h with or without lipopolysaccharide (LPS) (5 microg/ml) and in the absence or presence of FK 506 (0.1 and 1 microg/ml). The concentration of NO2- in culture supernatants was take...

journal_title：Physiological research

authors： Strestíková P,Otová B,Filipec M,Farghali H

更新日期：2000-01-01 00:00:00

abstract：:No data are available about the effects of AT1 receptor antagonist losartan on the skeleton and there is also little information on the activity of an ACE inhibitor enalapril on bone metabolism. It is widely believed that the vasculature plays an important role in bone remodeling under normal and pathological conditio...

journal_title：Physiological research

authors： Broulík PD,Tesar V,Zima T,Jirsa M

更新日期：2001-01-01 00:00:00

abstract：:In this study we compared several parameters characterizing differences in the lipoprotein profile between members of families with a positive or negative family history of coronary artery disease (CAD). In addition to regular parameters such as the body mass index (BMI), total plasma cholesterol (TC), low density (LD...

journal_title：Physiological research

authors： Dobiásová M,Raslová K,Rauchová H,Vohnout B,Ptácková K,Frohlich J

更新日期：2001-01-01 00:00:00

abstract：:Circadian clock plays an essential role in orchestrating daily physiology, and its disruption can evoke metabolic diseases such as obesity. L-Carnitine can reduce blood lipid levels, and ameliorate fatty liver through regulating lipid metabolism. However, whether L-Carnitine administration may affect the disturbance o...

journal_title：Physiological research

authors： Xie X,Guo A,Wu T,Hu Q,Huang L,Yao C,Zhao B,Zhang W,Chi B,Lu P,Zhao Z,Fu Z

更新日期：2017-11-24 00:00:00

abstract：:We report that decreased expression of miR-30c in tumor compared to adjacent tissue is sex-dependent in colorectal cancer (CRC) patients. High expression of miR-30c was associated with better survival in the whole cohort. When the cohort was split into male and female subcohorts, decreased miR-30c expression in tumor ...

journal_title：Physiological research

authors： Herichova I,Reis R,Hasakova K,Vician M

更新日期：2020-12-31 00:00:00

abstract：:Adiponectin is an adipokine increasing glucose and fatty acid metabolism and improving insulin sensitivity. The aim of this study was to investigate the role of adiponectin in the regulation of adipocyte lipolysis. Human adipocytes isolated from biopsies obtained during surgical operations from 16 non-obese and 17 obe...

journal_title：Physiological research

authors： Wedellová Z,Dietrich J,Siklová-Vítková M,Kološtová K,Kováčiková M,Dušková M,Brož J,Vedral T,Stich V,Polák J

更新日期：2011-01-01 00:00:00

abstract：:Polyunsaturated omega-3 fatty acids (omega-3 PUFA) are important components of cell membrane affecting its function and their deficiency is deleterious to health. We have previously shown that spontaneously hypertensive rats (SHR) are prone to life-threatening arrhythmias that are reduced by omega-3 PUFA intake. Purpo...

journal_title：Physiological research

authors： Bačová B,Seč P,Radošinská J,Certík M,Vachulová A,Tribulová N

更新日期：2013-01-01 00:00:00

abstract：:Quaternary benzo[c]phenanthridine alkaloids (QBA), fagaronine (FA), sanguinarine (SA), chelerythrine (CHE) and the QBA extract from Macleya cordata (EX) exerted differential inhibitory effect on the hydrolytic activity of particular dipeptidyl peptidase (DPP)-like enzyme isolated from human blood plasma and from human...

journal_title：Physiological research

authors： Sedo A,Malík R,Vicar J,Simánek V,Ulrichová J

更新日期：2003-01-01 00:00:00

abstract：:Neutral trehalase 1 (Nth1) from Saccharomyces cerevisiae catalyzes disaccharide trehalose hydrolysis and helps yeast to survive adverse conditions, such as heat shock, starvation or oxidative stress. 14-3-3 proteins, master regulators of hundreds of partner proteins, participate in many key cellular processes. Nth1 is...

journal_title：Physiological research

authors： Alblova M,Smidova A,Kalabova D,Lentini Santo D,Obsil T,Obsilova V

更新日期：2019-04-30 00:00:00

abstract：:Photodynamic therapy (PDT) is now being used more frequently in carefully selected cases of malignancies. The drugs used for PDT are mostly derivatives of haematoporphyrine (HPD) and its active component photofrine II. Another compound prepared by total synthesis is meso-tetra-(4-sulfonatophenyl)-porphine (TPPS4) but ...

journal_title：Physiological research

authors： Zima T,Jirsa M,Jirsa M Jr,Bradová V,Stejskal J,Zabka J,Povýsil C,Janebová M

更新日期：1997-01-01 00:00:00

abstract：:Recent results of the authors have demonstrated that the elevation of extracellular adenosine induced by the combined administration of dipyridamole, a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), a soluble adenosine prodrug, mediates radioprotective effects in mice. Furthermore...

journal_title：Physiological research

authors： Pospísil M,Hofer M,Vacek A,Netíková J,Pipalová I,Viklická S

更新日期：1993-01-01 00:00:00

abstract：:Familial hypocalciuric hypercalcemia (FHH) type 1, caused by a heterozygous inactivating mutation of the gene encoding the calcium-sensing receptor (CaSR), is characterized by mild to moderate hypercalcemia, hypocalciuria and inappropriately normal or elevated parathyroid hormone (PTH). FHH must be differentiated from...

journal_title：Physiological research

authors： Zajíčková K,Dvořáková M,Moravcová J,Včelák J,Goltzman D

更新日期：2020-09-30 00:00:00

abstract：:Metabolic acidosis could occur due to either endogenous acids accumulation or bicarbonate loss from the gastrointestinal tract or commonly from the kidney. This study aimed to investigate the possible underlying mechanism(s) of chronic acidosis-induced cardiac contractile and electrical changes in rats. Twenty four ad...

journal_title：Physiological research

authors： Lasheen NN,Mohamed GF

更新日期：2016-12-13 00:00:00

abstract：:Primary aldosteronism (PA) is the most common cause of endocrine hypertension with a high frequency of cardiovascular complications. The unfavorable cardiometabolic profile may be due to aldosterone-mediated activation of inflammatory cells, circulatory cytokines and activation of collagen synthesis in the vessel wall...

journal_title：Physiological research

authors： Šomlóová Z,Petrák O,Rosa J,Štrauch B,Indra T,Zelinka T,Haluzík M,Zikán V,Holaj R,Widimský J Jr

更新日期：2016-06-20 00:00:00