Abstract：
:We investigated the influence of oxygenation of in vitro lung preparation on the pulmonary vascular reactivity. Small pulmonary vessels isolated from adult male Wistar rats exposed for 4 days to hypoxia (F(iO2) = 0.1, group CH) were compared with those of normoxic controls (group N). The bath in the chamber of small vessel myograph was saturated with gas mixture containing either 21% or 95% of O(2) with 5% CO(2) and we measured the reactions of vessels to acute hypoxic challenge with 0% O(2) or to PGF(2alpha). We did not observe any difference of the contractile responses between both groups when the normoxic conditions were set in the bath. When the bath oxygenation was increased to 95% O(2), the contractions induced by hypoxic challenge and PGF(2alpha) decreased in chronically hypoxic rats and did not change in normoxic controls. We hypothesize that reduced reactivity of vessels from hypoxic rats in hyperoxia results from the effect of chronic hypoxia on Ca(2+) signaling in the vascular smooth muscle, which is modulated by increased free radical production during the exposure to chronic hypoxia and further hyperoxia.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Zaloudíková M,Vízek M,Herget Jsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
917-20issue
6eissn
0862-8408issn
1802-9973pii
931878journal_volume
58pub_type
杂志文章abstract：:Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and...
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pub_type： 杂志文章
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journal_title：Physiological research
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journal_title：Physiological research
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Physiological research
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doi：
更新日期：2003-01-01 00:00:00
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journal_title：Physiological research
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doi：
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journal_title：Physiological research
pub_type： 杂志文章,评审
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journal_title：Physiological research
pub_type： 杂志文章,评审
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doi：
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doi：
更新日期：2009-01-01 00:00:00
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doi：
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pub_type： 杂志文章
doi：
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
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更新日期：1992-01-01 00:00:00
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