Abstract：
:The gold standard material in bypass surgery of blood vessels remains the patient's own artery or vein. However, this material may be unavailable, or may suffer vein graft disease. Currently available vascular prostheses, namely polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE), perform well as large-caliber replacements, but their long-term patency is discouraging in small-caliber applications (<6 mm), such as in coronary, crural or microvessel surgery. This failure is mainly a result of an unfavorable healing process with surface thrombogenicity, due to lack of endothelial cells and anastomotic intimal hyperplasia caused by hemodynamic disturbances. An ideal small-diameter vascular graft has become a major focus of research. Novel biomaterials have been manufactured, and tissue-biomaterial interactions have been optimized. Tissue engineering technology has proven that the concept of partially or totally living blood vessels is feasible. The purpose of this review is to outline the vascular graft materials that are currently being implanted, taking into account cell-biomaterial physiology, tissue engineering approaches and the collective achievements of the authors.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Chlupác J,Filová E,Bacáková Lsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
S119-39eissn
0862-8408issn
1802-9973pii
931918journal_volume
58 Suppl 2pub_type
历史文章,杂志文章,评审abstract：:The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear superfamily of ligand-activated transcription factors. PPARgamma acts as a nutrient sensor that regulates several homeostatic functions. Its disruption can lead to vascular pathologies, disorders of fatty acid/lipid metabolism and insulin res...
journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.933439
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journal_title：Physiological research
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journal_title：Physiological research
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doi：
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pub_type： 杂志文章
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journal_title：Physiological research
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journal_title：Physiological research
pub_type： 杂志文章,评审
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
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doi：
更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-03-27 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
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更新日期：2018-12-18 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Physiological research
pub_type： 杂志文章
doi：
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journal_title：Physiological research
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doi：
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journal_title：Physiological research
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章
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