Abstract：
:Transgenic mice overexpressing a transthyretin promoter-ANF structural fusion gene have a life-long reduction in arterial blood pressure compared to nontransgenic littermates. The present study was designed to test the hypothesis that the high plasma level of ANF in the transgenic mice inhibits the renin-angiotensin and/or vasopressin systems, thereby causing the hypotension. Mice were anaesthetized with Inactin and arterial pressure and heart rate were monitored before and during Saralasin infusion and vasopressin V1 receptor blockade. Effectiveness of the blockade was determined by injection of angiotensin and vasopressin before and during Saralasin and V1 receptor antagonist administration. Saralasin was associated with hypotension in both transgenic and nontransgenic mice. The decrease in blood pressure was proportionally greater in the transgenic animals. Vasopressin receptor blockade had little effect on blood pressure in either group. Heart rates were not different between the groups during any maneuver. We conclude that the chronic hypotensive effect of ANF overproduction does not involve the inhibition of either renin-angiotensin or vasopressin systems. The data, however, suggest that the renin-angiotensin system may be stimulated in the ANF-transgenic mice.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Lichardus B,Veress AT,Field LJ,Sonnenberg Hsubject
Has Abstractpub_date
1994-01-01 00:00:00pages
145-50issue
3eissn
0862-8408issn
1802-9973journal_volume
43pub_type
杂志文章abstract：:Cancer therapy with daunorubicin is limited by its cardiotoxicity. It has been suggested that daunorubicin-induced free radical generation can be involved. The precise molecular mechanism of daunorubicin-induced cardiotoxicity is still not well understood but it is believed that mitochondria play an important role in ...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their level...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933410
更新日期：2017-07-18 00:00:00
abstract：:In the mammalian neocortex, the calcium-binding protein calretinin is expressed in a subset of cortical interneurons. In the recent years, research on interneurons is one of the most rapidly growing fields in neuroscience. This review summarizes the actual knowledge of the functions of calretinin in neuronal homeostas...
journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:Metabolic syndrome is a prevalent, complex condition. The search for genetic determinants of the syndrome is currently undergoing a paradigm enhancement by adding systems genetics approaches to association studies. We summarize the current evidence on relations between an emergent new candidate, zinc finger and BTB do...
journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.933730
更新日期：2017-09-26 00:00:00
abstract：:Kainic acid (KA) is a potent neurotoxic substance valuable in research of temporal lobe epilepsy. We tested how subconvulsive dose of KA influences spontaneous behavior of adult Wistar rats. Animals were treated with 5 mg/kg of KA and tested in Laboras open field test for one hour in order to evaluate various behavior...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932793
更新日期：2015-01-01 00:00:00
abstract：:Cardiac resynchronization therapy (CRT) has proven efficacious in reducing or even eliminating cardiac dyssynchrony and thus improving heart failure symptoms. However, quantification of mechanical dyssynchrony is still difficult and identification of CRT candidates is currently based just on the morphology and width o...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933805
更新日期：2017-12-30 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933534
更新日期：2016-12-22 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934142
更新日期：2020-02-19 00:00:00
abstract：:In this experiment we studied the effect of different pedalling rates during cycling at a constant power output (PO) 132+/-31 W (mean+/-S.D.), corresponding to 50% VO2 max, on the oxygen uptake and the magnitude of the slow component of VO2 kinetics in humans. The PO corresponded to 50% of VO2 max, established during ...
journal_title：Physiological research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-01-01 00:00:00
abstract：:The administration of a diet containing 5% of dried oyster mushroom to male Wistar rats fed a cholesterol diet (0.3%) shortly after weaning for 8 weeks reduced cholesterol levels in the serum and liver by 27 and 33%, respectively and increased the fractional turnover rate of 125I-very-low-density lipoproteins (VLDL) b...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:An oxidant/antioxidant imbalance is thought to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We hypothesized that antioxidant capacity reflected by erythrocyte glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activities, and serum levels of the l...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:The aim of this study was to investigate the effects of rooibos tea as a natural source of a wide scale of antioxidants on the prevention and treatment of oxidative stress in streptozotocin-induced diabetic rats. Expected significant changes of biochemical parameters characteristic for experimental diabetic state were...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933890
更新日期：2018-11-14 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932121
更新日期：2012-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934118
更新日期：2019-12-30 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The main role of research in medicine is to provide relevant knowledge which, after successful translation to clinical practice, improves the quality of healthcare. The sex bias which is still present in the majority of research disciplines prefers male subjects despite legislation changes in the US grant agencies and...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934593
更新日期：2020-12-31 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933543
更新日期：2017-11-24 00:00:00
abstract：:The paper presents an example of a new type of a structured model containing time delays in parallel branches. This model was selected as optimal to describe mathematically the lymphocyte migration between the venous blood and prescapular lymph in Merino ewes under physiological conditions. The model allowed to identi...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:MiRNAs are important regulators of gene expression and changes in their levels are linked with various pathological states, including solid tumors. MiR-215 has been identified as a tumor suppressor in colorectal cancer (CRC). Following our previous in vitro and in vivo experiments, the aim of this project was to study...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933546
更新日期：2016-12-21 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Continuous normobaric hypoxia (CNH) renders the heart more tolerant to acute ischemia/reperfusion injury. Protein kinase C (PKC) is an important component of the protective signaling pathway, but the contribution of individual PKC isoforms under different hypoxic conditions is poorly understood. The aim of this study ...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932860
更新日期：2015-01-01 00:00:00
abstract：:Progesterone and estradiol are the foremost steroid hormones in human pregnancy. However, the origin of maternal progesterone has still not been satisfactorily explained, despite the generally accepted opinion that maternal LDL-cholesterol is a single substrate for placental synthesis of maternal progesterone. The que...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.931807
更新日期：2010-01-01 00:00:00
abstract：:Research and clinical implications on novel cardiac biomarkers has intensified significantly in the past few years. The high-sensitive troponin T (hscTnT) assay plays a dominant role in diagnostic algorithm regarding myocardial injury in adults. Despite generally accepted use of hscTnT there are no data about physiolo...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933704
更新日期：2018-05-04 00:00:00
abstract：:Parenteral nutrition-associated liver disease (PNALD) is a severe complication in patients completely dependent on parenteral nutrition (PN). The gold diagnostic standard, liver biopsy, is associated with significant health risk and therefore its use is limited. MicroRNAs (miRNAs) are small non-coding regulatory RNA m...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934103
更新日期：2019-08-29 00:00:00
abstract：:Sensorineural hearing loss and vertigo, resulting from lesions in the sensory epithelium of the inner ear, have a high incidence worldwide. The sensory epithelium of the inner ear may exhibit extreme degeneration and is transformed to flat epithelium (FE) in humans and mice with profound sensorineural hearing loss and...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934447
更新日期：2020-11-16 00:00:00
abstract：:Remote ischemic preconditioning (RIPC) is a novel strategy of protection against ischemia-reperfusion (IR) injury in the heart (and/or other organs) by brief episodes of non-lethal IR in a distant organ/tissue. Importantly, RIPC can be induced noninvasively by limitation of blood flow in the extremity implying the app...
journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.933392
更新日期：2016-09-19 00:00:00
