Abstract：
:Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and 13 m/5 f with nephropathy) and 26 (14 m/12 f) healthy volunteers were examined using (31)P magnetic resonance spectroscopy at 3T tomograph at rest, and during and after a calf muscle exercise. The exercise consisted of a six-minute plantar flexion using a pedal ergometer followed by a six-minute recovery. It is reflected by reduced relative beta-ATP and increased Pi and phosphodiester signals to phosphocreatine (PCr) at rest and prolongation of the PCr recovery time after the exercise. Measurement on healthy volunteers indicated differences between males and females in pH at the rest and after the exercise only. These differences between patients groups were not significant. We have proven that nephropathy affects the metabolism in diabetic patients and our results confirm significant difference between patients with and without nephropathy. Gender differences in pH were observed only between male and female healthy volunteers.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Sedivy P,Dezortova M,Drobny M,Vlasakova Z,Herynek V,Hajek Mdoi
10.33549/physiolres.933745subject
Has Abstractpub_date
2018-07-17 00:00:00pages
433-441issue
3eissn
0862-8408issn
1802-9973pii
933745journal_volume
67pub_type
杂志文章abstract：:The goal of this study is to evaluate if promotion of angiogenesis by systemic treatment with an antagomir against miR-92a, a well established inhibitor of angiogenesis, will maximize the benefits of exercise on bone. Ten week old female C57BL6/J mice were subjected to two weeks of external load by four point bending....
journal_title：Physiological research
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932379
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doi：10.33549/physiolres.932019
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journal_title：Physiological research
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doi：
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journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.33549/physiolres.932658
更新日期：2014-01-01 00:00:00
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doi：
更新日期：2007-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933101
更新日期：2017-07-18 00:00:00
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pub_type： 临床试验,杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章
doi：10.33549/physiolres.933805
更新日期：2017-12-30 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:I am pleased to introduce this special issue of Physiological Research published on the occasion of the 60th anniversary of the Institute of Physiology. It is only a second issue of this kind, the previous one being Physiological Research 53 (Suppl. 1) 2004. Since then, the Institute contributed its expertise to moder...
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doi：
更新日期：2014-01-01 00:00:00
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