Enteral administration of lipid emulsions protects liver cytochrome c oxidase from hepatotoxic action of thioacetamide.

abstract：:Kainic acid (KA) is a potent neurotoxic substance valuable in research of temporal lobe epilepsy. We tested how subconvulsive dose of KA influences spontaneous behavior of adult Wistar rats. Animals were treated with 5 mg/kg of KA and tested in Laboras open field test for one hour in order to evaluate various behavior...

journal_title：Physiological research

authors： Riljak V,Marešová D,Pokorný J,Jandová K

更新日期：2015-01-01 00:00:00

abstract：:Calcium cycling is a major determinant of cardiac function. S100A1 is the most abundant member of the calcium-binding S100 protein family in myocardial tissue. S100A1 interacts with a variety of calcium regulatory proteins such as SERCA2a, ryanodine receptors, L-type calcium channels and Na(+)/Ca(2+) exchangers, thus ...

journal_title：Physiological research

authors： Duarte-Costa S,Castro-Ferreira R,Neves JS,Leite-Moreira AF

更新日期：2014-01-01 00:00:00

abstract：:The goal of this study is to evaluate if promotion of angiogenesis by systemic treatment with an antagomir against miR-92a, a well established inhibitor of angiogenesis, will maximize the benefits of exercise on bone. Ten week old female C57BL6/J mice were subjected to two weeks of external load by four point bending....

journal_title：Physiological research

authors： Sengul A,Santisuk R,Xing W,Kesavan C

更新日期：2013-01-01 00:00:00

abstract：:We analyzed the effect of FK 506 on the production of nitric oxide by macrophages. Isolated rat peritoneal macrophages were cultured for 24 h with or without lipopolysaccharide (LPS) (5 microg/ml) and in the absence or presence of FK 506 (0.1 and 1 microg/ml). The concentration of NO2- in culture supernatants was take...

journal_title：Physiological research

authors： Strestíková P,Otová B,Filipec M,Farghali H

更新日期：2000-01-01 00:00:00

abstract：:Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and...

journal_title：Physiological research

authors： Sedivy P,Dezortova M,Drobny M,Vlasakova Z,Herynek V,Hajek M

更新日期：2018-07-17 00:00:00

abstract：:The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in t...

journal_title：Physiological research

authors： Ziaaldini MM,Hosseini SR,Fathi M

更新日期：2017-03-31 00:00:00

abstract：:The aim of this study was to assess the molecular basis of renal Na,K-ATPase disturbances in response to NO-deficient hypertension induced in rats by NO-synthase inhibition with 40 mg/kg/day N(G)-nitro-L-arginine methyl ester (L-NAME) for four weeks. After 4-week administration of L-NAME, the systolic blood pressure (...

journal_title：Physiological research

authors： Vrbjar N,Javorková V,Pechánová O

更新日期：2002-01-01 00:00:00

abstract：:This study was designated to estimate protective role of ETA and ETB receptor antagonist against endothelin 1 (ET-1)-induced oxidative stress in lungs and determine whether these effects are mediated by nitric oxide (NO) synthase. Experiments were performed on Wistar rats divided into the following groups: I - saline ...

journal_title：Physiological research

authors： Kleniewska P,Gorąca A

更新日期：2016-11-23 00:00:00

abstract：:The present study was designed to measure interstitial levels of norepinephrine-regulating lipolysis (NE) in subcutaneous abdominal adipose tissue of anorexia nervosa (AN) patients and control subjects under basal conditions and after the local administration of an inhibitor of NE re-uptake, maprotiline. In vivo micro...

journal_title：Physiological research

authors： Nedvídková J,Dostálová I,Barták V,Papezov H,Pacák K

更新日期：2004-01-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) therapy, i.e. breathing pure oxygen under increased environmental pressures serves as a treatment for diverse medical conditions. However, elevated oxygen concentration can be detrimental to central nervous system or lungs. Our study aimed to evaluate the effects of repeated exposure to HBO on ...

journal_title：Physiological research

authors： Dejmek J,Kohoutová M,Kripnerová M,Čedíková M,Tůma Z,Babuška V,Bolek L,Kuncová J

更新日期：2018-12-31 00:00:00

abstract：:Rhythmic daily changes in the Na,K-ATPase activity have been previously described for rat kidney cortex, showing two peaks: at 0900 h and 2100 h, and two valleys: at 1500 h and 0100 h -0300 h. The oscillations in Na,K-ATPase activity are produced by an inhibitor, which binds the enzyme and is present in the rat blood ...

journal_title：Physiological research

authors： Reyes A,Galindo MM,García L,Segura-Pena D,Caruso-Neves C,Eblen-Zajjur A,Proverbio T,Marín R,Proverbio F

更新日期：2009-01-01 00:00:00

abstract：:Wire myograph is a device for the in vitro investigation of both, active and passive properties of arteries. Arteries from a variety of animal species, pathological states, and vascular beds were investigated using this method. We focus on the normalization procedure which is aimed to standardize experimental settings...

journal_title：Physiological research

authors： Slezák P,Waczulíková I,Bališ P,Púzserová A

更新日期：2010-01-01 00:00:00

abstract：:We examined cardioprotective effect of chronic hypoxia and the time course of its recovery under normoxic conditions. Adult male Wistar rats were exposed to intermittent hypobaric hypoxia (7000 m, 8 h/day, 35 exposures) and susceptibility of their hearts to ischemia-induced ventricular arrhythmias and myocardial infar...

journal_title：Physiological research

authors： Neckár J,Ostádal B,Kolár F

更新日期：2004-01-01 00:00:00

abstract：:Interspecies differences in glycosidation potential in mammalian tissues represent a factor contributing to ambiguity when endobiotic and/or xenobiotic metabolic pathways are extrapolated from animals to man. Using the TLC/autoradiographic technique, we conducted an in vitro investigation involving mouse, rat, monkey,...

journal_title：Physiological research

authors： Cervenková K,Belejová M,Chmela Z,Rypka M,Riegrová D,Michnová K,Michalíková K,Súrová I,Brejcha A,Hanus J,Cerný B,Fuksová K,Havlícek L,Veselý J

更新日期：2003-01-01 00:00:00

abstract：:Familial hypercholesterolemia (FH) is most frequently caused by LDLR or APOB mutations. Therefore, the aim of our study was to examine the genetic background of Slovak patients suspected of FH. Patients with clinical suspicion of FH (235 unrelated probands and 124 family relatives) were recruited throughout Slovakia d...

journal_title：Physiological research

authors： Gabčová D,Vohnout B,Staníková D,Hučková M,Kadurová M,Debreová M,Kozárová M,Fábryová Ľ,Staník J,Klimeš I,Rašlová K,Gašperiková D

更新日期：2017-03-31 00:00:00

abstract：:Store-operated calcium entry (SOCE) is one of regulatory mechanisms which regulates Ca2+ cycling in the heart. SOCE alterations in pathological conditions contribute to progression of heart failure and cardiac hypertrophy by multiple signaling pathways such as Cn/NFAT and CaMKII/MEF2. Several components mediating SOCE...

journal_title：Physiological research

authors： Čendula R,Dragún M,Gažová A,Kyselovič J,Hulman M,Máťuš M

更新日期：2019-11-30 00:00:00

abstract：:Pulmonary hypertension (PH) unresponsive to pharmacological intervention is considered a contraindication for orthotopic heart transplantation (OHTX) due to risk of postoperative right-heart failure. In this prospective study, we describe our experience with a treatment strategy of improving severe PH in heart transpl...

journal_title：Physiological research

authors： Kettner J,Dorazilová Z,Netuka I,Malý J,Al-Hiti H,Melenovský V,Skalský I,Říha H,Málek I,Kautzner J,Pirk J

更新日期：2011-01-01 00:00:00

abstract：:Hepcidin, a recently discovered antimicrobial peptide synthesized in the liver, was identified to be the key mediator of iron metabolism and distribution. Despite our knowledge of hepcidin increased in recent years, there are only limited data on hepcidin regulation during systemic inflammatory response in human subje...

journal_title：Physiological research

authors： Maruna P,Vokurka M,Lindner J

更新日期：2011-01-01 00:00:00

abstract：:The aim of the present study was to compare the oscillations of oxygenation in skeletal muscle between early and late phases in prolonged exercise. During prolonged exercise at 60 % of peak oxygen uptake (V(.)o(2)) for 60 min and at rest, oxygenated hemoglobin/myoglobin (Hb/MbO(2)) and total Hb/Mb (THb/Mb) were determ...

journal_title：Physiological research

authors： Yano T,Lian CS,Arimitsu T,Yamanaka R,Afroundeh R,Shirakawa K,Yunoki T

更新日期：2013-01-01 00:00:00

abstract：:Hindlimb unweighting (HU) leads to capillary regression in skeletal muscle. However, the molecular mechanism(s) remains to be elucidated. To gain insight into the regulation of this process, we investigated gene expression of hypoxia-inducible factor-1alpha (HIF-1alpha)vascular endothelial growth factor (VEGF), angiop...

journal_title：Physiological research

authors： Wagatsuma A

更新日期：2008-01-01 00:00:00

abstract：:As an autoimmune disease, type 1 diabetes mellitus (DM) can be associated with other autoimmune disorders. The aim of this study was to detect subclinically associated autoimmune thyroid disease, coeliac disease, and Addison's disease. The presence of autoantibodies was evaluated with special regard to the control of ...

journal_title：Physiological research

authors： Prázný M,Skrha J,Límanová Z,Vanícková Z,Hilgertová J,Prázná J,Jaresová M,Stríz I

更新日期：2005-01-01 00:00:00

abstract：:Reduced physical activity and abundant energy intake are two most common factors leading to uncontrolled body weight gain. But these factors are not under entire internal consciousness control; they are also partially genetically determined and are affected by for example food marketing practices. In addition to these...

journal_title：Physiological research

authors： Hubácek JA

更新日期：2009-01-01 00:00:00

abstract：:Spontaneous activity of cortical neurons exhibits alternative fluctuations of membrane potential consisting of phased depolarization called "up-state" and persistent hyperpolarization called "down-state" during slow wave sleep and anesthesia. Here, we examined the effects of sound stimuli (noise bursts) on neuronal ac...

journal_title：Physiological research

authors： Zhang Y,Han L,Xiao X,Hu B,Ruan H,Xiong Y

更新日期：2011-01-01 00:00:00

abstract：:Dihydrotestosterone (DHT) originates via irreversible reduction of testosterone by catalytic activity of 5alpha-reductase enzyme and it is demonstratively the most effective androgen. Androgens influence adipose tissue in men either directly by stimulation of the androgen receptor or indirectly, after aromatization, b...

journal_title：Physiological research

authors： Dušková M,Pospíšilová H

更新日期：2011-01-01 00:00:00

abstract：:Oxidative stress markers are usually measured in plasma, a stable environment for biomarkers. Blood collection is invasive, but the use of alternative biofluids is limited, due to high variability. In this study, we aimed to establish reference values for oxidative stress markers in plasma, urine and saliva of adult, ...

journal_title：Physiological research

authors： Gyurászová M,Kovalčíková A,Janšáková K,Šebeková K,Celec P,Tóthová Ľ

更新日期：2018-12-18 00:00:00

abstract：:The review aims to summarize current knowledge on the effects of moderate alcohol consumption (1 standard drink a day for women; 2 drinks a day for men) on triglyceride concentration in circulation. Current evidence suggests that the relationship between alcohol consumption and triglyceridemia is J-shaped. Triglycerid...

journal_title：Physiological research

authors： Kovář J,Zemánková K

更新日期：2015-01-01 00:00:00

abstract：:Monoaminergic neurotransmitter 5-hydroxytryptamine (5-HT), also known as serotonin, plays important roles in modulating the function of the olfactory system. However, thus far, the knowledge about 5-HT and its receptors in olfactory receptor neurons (ORNs) and their physiological role have not been fully characterized...

journal_title：Physiological research

authors： Gao S,Guo X,Liu T,Liu J,Chen W,Xia Q,Chen Y,Tang Y

更新日期：2013-01-01 00:00:00

abstract：:In this retrospective study we analysed changes of the ST segment in patients with arterial hypertension using multi-lead body surface mapping of the electric heart field as the ST segment often shows non-specific changes and is influenced by many different conditions. We constructed isointegral maps (IIM) of chosen i...

journal_title：Physiological research

authors： Kozlíková K,Martinka J,Bulas J

更新日期：2012-01-01 00:00:00

abstract：:Male rats aged 45, 85, 145 and 270 days (daily body mass increments on an optimal diet containing casein were 6.73, 2.88, 0.53 and 0.31 g respectively) were fed 15 days ad libitum on a diet with a nutrient content physiological for their age, in which the protein source was milk casein (ratio of essential to nonessent...

journal_title：Physiological research

authors： Krajcovicová-Kudlácková M

更新日期：1992-01-01 00:00:00

abstract：:Whole blood surface tension of 15 healthy subjects recorded by the ring method was investigated in the temperature range from 20 to 40 degrees C. The surface tension omega as a function of temperature t ( degrees C) is described by an equation of linear regression as omega(t) = (-0.473 t + 70.105) x 10(-3) N/m. Blood ...

journal_title：Physiological research

authors： Rosina J,Kvasnák E,Suta D,Kolárová H,Málek J,Krajci L

更新日期：2007-01-01 00:00:00