Serotonin modulates outward potassium currents in mouse olfactory receptor neurons.

abstract：:Dihydrotestosterone (DHT) originates via irreversible reduction of testosterone by catalytic activity of 5alpha-reductase enzyme and it is demonstratively the most effective androgen. Androgens influence adipose tissue in men either directly by stimulation of the androgen receptor or indirectly, after aromatization, b...

journal_title：Physiological research

authors： Dušková M,Pospíšilová H

更新日期：2011-01-01 00:00:00

abstract：:Differential pulse voltammetry with a carbon fibre microelectrode (ME) was used in pentobarbital-anaesthetized rats for monitoring the stobadine current (STB.C) on both sides of the blood-brain barrier (BBB) in the arterial bloodstream (BS) and in the corpus striatum (CS). The STB.C exhibited a distinct peak at a pola...

journal_title：Physiological research

authors： Pavlásek J,Haburcák M,Masánová C,Stolc S

更新日期：1996-01-01 00:00:00

abstract：:Evaluation of possible interactions with enzymes of drug metabolism is an important part of studies on safety and, in general, on the properties of any drug or biologically active compound. Here, focus is given on interactions of three sesquiterpenes (beta-caryophyllene oxide (CAO), trans-nerolidol (tNER) and farnesol...

journal_title：Physiological research

authors： Špičáková A,Bazgier V,Skálová L,Otyepka M,Anzenbacher P

更新日期：2019-11-22 00:00:00

abstract：:The concept of vena contracta space reduction in tricuspid valve position was tested in an animal model. Feasibility of specific artificial obturator body (REMOT) fixed to the right ventricular apex and interacting with tricuspid valve leaflets was evaluated in three different animal studies. Catheter-based technique ...

journal_title：Physiological research

authors： Sochman J,Peregrin JH,Pavcnik D,Uchida BT,Timmermans HA,Sedmera D,Benada O,Kofronova O,Keller FS,Rosch J

更新日期：2014-01-01 00:00:00

abstract：:Eukaryotic cytochrome c oxidase (CcO), the terminal component of the mitochondrial electron transport chain is a heterooligomeric complex that belongs to the superfamily of heme-copper containing terminal oxidases. The enzyme, composed of both mitochondrially and nuclear encoded subunits, is embedded in the inner mito...

journal_title：Physiological research

authors： Stiburek L,Hansikova H,Tesarova M,Cerna L,Zeman J

更新日期：2006-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) acts on ET(A) and ET(B) receptors and has been implicated in hemorrhagic shock (shock). We determined effect of shock and resuscitation by hypertonic saline (saline) or centhaquin on ET(A) and ET(B) receptor expression. Rats were anesthetized, a pressure catheter was placed in the left femoral arte...

journal_title：Physiological research

authors： Briyal S,Gandhakwala R,Khan M,Lavhale MS,Gulati A

更新日期：2018-06-27 00:00:00

abstract：:The overproduction of the free radical nitric oxide (NO) by activated immunocompetent cells with subsequent development of local oxidative stress is supposed to be one of the possible pathophysiological mechanisms of beta-cell damage during streptozotocin-induced diabetes. The blockade of increased NO production by si...

journal_title：Physiological research

authors： Haluzík M,Nedvídková J

更新日期：2000-01-01 00:00:00

abstract：:This study was designated to estimate protective role of ETA and ETB receptor antagonist against endothelin 1 (ET-1)-induced oxidative stress in lungs and determine whether these effects are mediated by nitric oxide (NO) synthase. Experiments were performed on Wistar rats divided into the following groups: I - saline ...

journal_title：Physiological research

authors： Kleniewska P,Gorąca A

更新日期：2016-11-23 00:00:00

abstract：:We studied the effect of thiazide-like diuretic--indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) and assessed the involvement of nitric oxide in this process. Six-week-old male SHR were treated with indapamide (1 mg/kg/day) for six weeks. Age-matched SHR were use...

journal_title：Physiological research

authors： Janega P,Kojsová S,Jendeková L,Babál P,Pechánová O

更新日期：2007-01-01 00:00:00

abstract：:The effect of suramin, an inhibitor of G protein regulated signalling, was studied on the membrane currents induced by noxious heat and by capsaicin in cultured dorsal root ganglia neurones isolated from neonatal rats. Whole-cell responses induced by a heat ramp (24-52 degrees C) were little affected by suramin. The n...

journal_title：Physiological research

authors： Vlachová V,Lyfenko A,Vyklický L,Orkand RK

更新日期：2002-01-01 00:00:00

abstract：:In this experiment we studied the effect of different pedalling rates during cycling at a constant power output (PO) 132+/-31 W (mean+/-S.D.), corresponding to 50% VO2 max, on the oxygen uptake and the magnitude of the slow component of VO2 kinetics in humans. The PO corresponded to 50% of VO2 max, established during ...

journal_title：Physiological research

authors： Zoladz JA,Duda K,Majerczak J

更新日期：1998-01-01 00:00:00

abstract：:Cardiovascular disease, while rare in women of reproductive age, is the main cause of mortality in menopause. The purpose of our study was to determine the association of natural menopause with cardiovascular risk factors, including their clustering into metabolic syndrome (MS). A random 5 % representative population ...

journal_title：Physiological research

authors： Lejsková M,Alušík S,Valenta Z,Adámková S,Piťha J

更新日期：2012-01-01 00:00:00

abstract：:We determined and characterized the Mg2+-dependent, Ca2+-stimulated ATPase (Ca-ATPase) activity in cell plasma membranes from the myometrium of pregnant women, and compared these characteristics to those of the active Ca2+-transport already demonstrated in this tissue. Similarly to the Ca2+-transport system, the Ca2+-...

journal_title：Physiological research

authors： Carrera F,Proverbio T,Marín R,Proverbio F

更新日期：2000-01-01 00:00:00

abstract：:We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of gamma-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, ...

journal_title：Physiological research

authors： Hofer M,Hoferová Z,Gruzdev A,Dušek L,Falk M

更新日期：2018-11-14 00:00:00

abstract：:Spontaneous activity of cortical neurons exhibits alternative fluctuations of membrane potential consisting of phased depolarization called "up-state" and persistent hyperpolarization called "down-state" during slow wave sleep and anesthesia. Here, we examined the effects of sound stimuli (noise bursts) on neuronal ac...

journal_title：Physiological research

authors： Zhang Y,Han L,Xiao X,Hu B,Ruan H,Xiong Y

更新日期：2011-01-01 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) has proven efficacious in reducing or even eliminating cardiac dyssynchrony and thus improving heart failure symptoms. However, quantification of mechanical dyssynchrony is still difficult and identification of CRT candidates is currently based just on the morphology and width o...

journal_title：Physiological research

authors： Kittnar O,Riedlbauchová L,Tomis J,LoŽek M,Valeriánová A,Hrachovina M,Mlček M,Huptych M,Janoušek J,Lhotská L

更新日期：2017-12-30 00:00:00

abstract：:The most common etiology of non-syndromic monogenic obesity are mutations in gene for the Melanocortin-4 receptor (MC485) with variable prevalence in different countries (1.2-6.3 % of obese children). The aim of our study was 1) to search for MC4R mutations in obese children in Slovakia and compare their prevalence wi...

journal_title：Physiological research

authors： Stanikova D,Surova M,Ticha L,Petrasova M,Virgova D,Huckova M,Skopkova M,Lobotkova D,Valentinova L,Mokan M,Stanik J,Klimes I,Gasperikova D

更新日期：2015-01-01 00:00:00

abstract：:The left and right ventricle originate from distinct parts of the cardiac tube, and several genes are known to be differentially expressed in these compartments. The aims of this study were to determine developmental differences in gene expression between the left and right ventricle, and to assess the effect of alter...

journal_title：Physiological research

authors： Krejčí E,Pesevski Z,DeAlmeida AC,Mrug M,Fresco VM,Argraves WS,Barth JL,Cui X,Sedmera D

更新日期：2012-01-01 00:00:00

abstract：:Impaired cerebrovascular reactivity (CVR), an important risk factor for future stroke, is affected by a presence carotid stenosis. However, in some cases CVR can be impaired in the absence of carotid stenosis due to several poorly characterized mechanisms. We hypothesized that arterial stiffening as observed in corona...

journal_title：Physiological research

authors： Rucka D,Marek J,Rucklova Z,Lubanda JC,Havranek S,Skvaril J,Varejka P,Chochola M,Karetova D,Korinek J,Linhart A

更新日期：2015-01-01 00:00:00

abstract：:Plant-based n-3 polyunsaturated fatty acids (PUFA) possess a prospective antiatherogenic potential. Currant oil from Ribes nigrum L. is one of the few plant oils containing PUFAn-3 (15.3 mol%) in addition to PUFAn-6 (60.5 mol%). This study was aimed at comparing the effects of currant oil with those of lard fat, rich ...

journal_title：Physiological research

authors： Vecera R,Skottová N,Vána P,Kazdová L,Chmela Z,Svagera Z,Walterá D,Ulrichová J,Simánek V

更新日期：2003-01-01 00:00:00

abstract：:Gain-of-function (GOF) mutations in ion channels are rare events, which lead to increased agonist sensitivity or altered gating properties, and may render the channel constitutively active. Uncovering and following characterization of such mutants contribute substantially to the understanding of the molecular basis of...

journal_title：Physiological research

authors： Boukalova S,Touska F,Marsakova L,Hynkova A,Sura L,Chvojka S,Dittert I,Vlachova V

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present work was to investigate a new mechanism likely contributing to the toxic action of acetaminophen, especially to explore the possible inhibition of glutathione reductase through an acetaminophen-glutathione conjugate (APAP-SG). APAP-SG conjugate was synthesized by organic synthesis and purified b...

journal_title：Physiological research

authors： Rousar T,Pařík P,Kucera O,Bartos M,Červinková Z

更新日期：2010-01-01 00:00:00

abstract：:Adaptation to intermittent high altitude hypoxia (IHAH) increases tolerance of the isolated neonatal rat heart to ischemia and potentiates protection induced by ischemic preconditioning. In addition to the protective effect, IHAH significantly reduces growth of the animals. The aim of the present study was, therefore,...

journal_title：Physiological research

authors： Chvojková Z,Ostádalová I,Ostádal B

更新日期：2005-01-01 00:00:00

abstract：:Digitonin solubilizes mitochondrial membrane, breaks the integrity of the respiratory chain and releases two mobile redox-active components: coenzyme Q (CoQ) and cytochrome c (cyt c). In the present study we report the inhibition of glycerol-3-phosphate- and succinate-dependent oxygen consumption rates by digitonin tr...

journal_title：Physiological research

authors： Rauchová H,Vokurková M,Drahota Z

更新日期：2012-01-01 00:00:00

abstract：:We investigated the effects of different weight loss protocols on leptin levels in obese females with the aim of addressing the leptin resistance which has been found to be an aggravating factor in obesity. Twenty-four obese females enrolled to one of three 12-week weight loss protocols: orlistat-induced weight loss (...

journal_title：Physiological research

authors： Ozcelik O,Dogan H,Celik H,Ayar A,Serhatlioglu S,Kelestimur H

更新日期：2005-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of rooibos tea as a natural source of a wide scale of antioxidants on the prevention and treatment of oxidative stress in streptozotocin-induced diabetic rats. Expected significant changes of biochemical parameters characteristic for experimental diabetic state were...

journal_title：Physiological research

authors： Ulicná O,Vancová O,Bozek P,Cársky J,Sebeková K,Boor P,Nakano M,Greksák M

更新日期：2006-01-01 00:00:00

abstract：:Leptin and adiponectin, two adipocytokines, may work together in regulating energy homeostasis and insulin action. Leptin gene expression has been investigated in term placental tissue complicated by gestational diabetes mellitus (GDM), but never in conjunction with all isoforms of the leptin receptor (LEPR A-D), or w...

journal_title：Physiological research

authors： Meller M,Qiu C,Vadachkoria S,Abetew DF,Luthy DA,Williams MA

更新日期：2006-01-01 00:00:00

abstract：:The incidence of metabolic syndrome increases in the developed countries, therefore biomedical research is focused on the understanding of its etiology. The study of exact mechanisms is very complicated because both genetic and environmental factors contribute to this complex disease. The ability of environmental fact...

journal_title：Physiological research

authors： Kuneš J,Vaněčková I,Mikulášková B,Behuliak M,Maletínská L,Zicha J

更新日期：2015-01-01 00:00:00

abstract：:Metabolic syndrome and one of its manifestations, essential hypertension, is an important cause of worldwide morbidity and mortality. Morbidity and mortality associated with hypertension are caused by organ complications. Previously we revealed a decrease of blood pressure and an amelioration of cardiac fibrosis in a ...

journal_title：Physiological research

authors： Mirchi LF,Chylíková B,Janků M,Šeda O,Liška F

更新日期：2019-10-25 00:00:00

abstract：:The goal of this study is to evaluate if promotion of angiogenesis by systemic treatment with an antagomir against miR-92a, a well established inhibitor of angiogenesis, will maximize the benefits of exercise on bone. Ten week old female C57BL6/J mice were subjected to two weeks of external load by four point bending....

journal_title：Physiological research

authors： Sengul A,Santisuk R,Xing W,Kesavan C

更新日期：2013-01-01 00:00:00