Transport of an antihypoxic drug stobadine across the blood-brain barrier in rat striatum and its influence on catecholamine-oxidative current: a voltammetric study under normal and anoxic/ischaemic conditions.

abstract：:The total protein glycosylation profile and specific activity of lysosomal enzymes were investigated in rat submandibular glands isolated from very young (1-month), young (1.5-months) and adult rats (3-months) rats. The specific activity of lysosomal hydrolases (i.e. acid phosphatase, arylsulfatases A and B, beta-N-ac...

journal_title：Physiological research

authors： Przybyło M,Lityńska A,Hoja-Łukowicz D,Kremser E

更新日期：2004-01-01 00:00:00

abstract：:Hypolipidemic and cardioprotective effects of statins can be associated with the development of myopathies and new-onset type 2 diabetes. These adverse effects may be related to increased oxidative stress. The plant extract silymarin (SM) is known for its antioxidant and anti-inflammatory actions. We tested the hypoth...

journal_title：Physiological research

authors： Marková I,Malínská H,Hüttl M,Miklánková D,Oliyarnyk O,Poruba M,Rácová Z,Kazdová L,Večeřa R

更新日期：2021-01-14 00:00:00

abstract：:Aquaporin proteins (AQPs) are a family of channels expressed in numerous mammalian tissues, where they play a fundamental role in regulating water transport across cell membranes. Based on reports that AQPs are present in the reproductive system and participate in reproductive processes, our aim was to investigate the...

journal_title：Physiological research

authors： Skowronska A,Mlotkowska P,Majewski M,Nielsen S,Skowronski MT

更新日期：2016-11-08 00:00:00

abstract：:The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. ...

journal_title：Physiological research

authors： Barančík M,Grešová L,Barteková M,Dovinová I

更新日期：2016-09-19 00:00:00

abstract：:Glucose tolerance, insulin binding to erythrocytes, insulinaemia, plasma total cholesterol, plasma triglycerides, weight of fat pads, food consumption and body weight changes were studied in genetically hypertensive lean Koletsky rats. Long-term treatment with dopaminergic agonist terguride (0.2 mg/kg/day) normalized ...

journal_title：Physiological research

authors： Golda V,Hilgertová J

更新日期：1997-01-01 00:00:00

abstract：:Steroids are important markers in pregnancy. Although estimating their levels separately in umbilical arterial (UA) and venous blood (UV) enable more precise insights into the functioning fetoplacental unit compared to using mixed umbilical blood (UM), selective aspiration of UA and UV is technically more demanding th...

journal_title：Physiological research

authors： Pašková A,Pařízek A,Hill M,Velíková M,Kubátová J,Dušková M,Adamcová K,Koucký M,Simjak P,Černý A,Stárka L

更新日期：2014-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) acts on ET(A) and ET(B) receptors and has been implicated in hemorrhagic shock (shock). We determined effect of shock and resuscitation by hypertonic saline (saline) or centhaquin on ET(A) and ET(B) receptor expression. Rats were anesthetized, a pressure catheter was placed in the left femoral arte...

journal_title：Physiological research

authors： Briyal S,Gandhakwala R,Khan M,Lavhale MS,Gulati A

更新日期：2018-06-27 00:00:00

abstract：:The haemolytic action of HgCl2 (0, 15 mmol.l-1) was studied in relation to the ionic strength and concentration of glucose and saccharose in incubating medium. Blood from 94 donors, aged 19-46 years were used in our experiments. In relation to the ionic strength the haemolytic action was characteristic with two maxima...

journal_title：Physiological research

authors： Nicák A,Mojzis J

更新日期：1992-01-01 00:00:00

abstract：:Male rats aged 45, 85, 145 and 270 days (daily body mass increments on an optimal diet containing casein were 6.73, 2.88, 0.53 and 0.31 g respectively) were fed 15 days ad libitum on a diet with a nutrient content physiological for their age, in which the protein source was milk casein (ratio of essential to nonessent...

journal_title：Physiological research

authors： Krajcovicová-Kudlácková M

更新日期：1992-01-01 00:00:00

abstract：:Slow breathing training reduces resting blood pressure, probably by modifying central autonomic control, but evidence for this is lacking. The pressor response to static handgrip exercise is a measure of autonomic control and the aim of this study was to determine whether slow breathing training modulates the pressor ...

journal_title：Physiological research

authors： Jones CU,Sangthong B,Pachirat O,Jones DA

更新日期：2015-01-01 00:00:00

abstract：:The role of [Ca2+]i and cAMP in transduction of the melatonin inhibitory effect on GnRH-induced LH release from neonatal rat gonadotrophs has been studied, because melatonin inhibits the increase of both intracellular messengers. Treatments increasing Ca2+ influx (S(-) Bay K8644 or KCI) or cAMP concentration (8-bromo-...

journal_title：Physiological research

authors： Vanecek J

更新日期：1998-01-01 00:00:00

abstract：:The frequencies of the alleles of XbaI polymorphism in the apolipoprotein B gene were determined in two groups of children, 82 with high (HCG) and 86 with low (LCG) cholesterol levels. A slightly higher incidence of the X2X2 genotype in HCG was found, but the differences were not statistically significant. No relation...

journal_title：Physiological research

authors： Hubácek JA,Pistulková H,Písa Z,Valenta Z,Skodová Z,Poledne R

更新日期：1998-01-01 00:00:00

abstract：:Impaired cerebrovascular reactivity (CVR), an important risk factor for future stroke, is affected by a presence carotid stenosis. However, in some cases CVR can be impaired in the absence of carotid stenosis due to several poorly characterized mechanisms. We hypothesized that arterial stiffening as observed in corona...

journal_title：Physiological research

authors： Rucka D,Marek J,Rucklova Z,Lubanda JC,Havranek S,Skvaril J,Varejka P,Chochola M,Karetova D,Korinek J,Linhart A

更新日期：2015-01-01 00:00:00

abstract：:Circadian clock plays an essential role in orchestrating daily physiology, and its disruption can evoke metabolic diseases such as obesity. L-Carnitine can reduce blood lipid levels, and ameliorate fatty liver through regulating lipid metabolism. However, whether L-Carnitine administration may affect the disturbance o...

journal_title：Physiological research

authors： Xie X,Guo A,Wu T,Hu Q,Huang L,Yao C,Zhao B,Zhang W,Chi B,Lu P,Zhao Z,Fu Z

更新日期：2017-11-24 00:00:00

abstract：:The mitochondrial DNA (mtDNA) amount in cells as the basis for mitochondrial energy generating system, which produces ATP, plays an important role in the fetal development and postnatal morbidity. Isolated human cord blood leukocytes (HCBL) contribute very little to the overall metabolic turnover, but they may serve a...

journal_title：Physiological research

authors： Pejznochová M,Tesarová M,Honzík T,Hansíková H,Magner M,Zeman J

更新日期：2008-01-01 00:00:00

abstract：:Our experiments on metabolic processes in the rumen were performed on sixteen 5-month-old lambs divided into 4 groups (defaunated - D, totally refaunated - T, partially refaunated - P and intact - I). The absence or presence of protozoa in the rumen did not significantly affect the pH values. The greatest differences ...

journal_title：Physiological research

authors： Fejes J,Várady J

更新日期：1996-01-01 00:00:00

abstract：:The purpose of the study was to check whether hypoxia of corneal tissue increases the collagenolytic activity due to release of reactive oxygen and nitrogen species. Rats were exposed to hypoxia 10% O(2) for 4, 14, and 21 days. The radical tissue injury was measured by the level of nitrotyrosine and changes in the lip...

journal_title：Physiological research

authors： Mahelková G,Korynta J,Moravová A,Novotná J,Vytásek R,Wilhelm J

更新日期：2008-01-01 00:00:00

abstract：:Reduced physical activity and abundant energy intake are two most common factors leading to uncontrolled body weight gain. But these factors are not under entire internal consciousness control; they are also partially genetically determined and are affected by for example food marketing practices. In addition to these...

journal_title：Physiological research

authors： Hubácek JA

更新日期：2009-01-01 00:00:00

abstract：:This study attempted to compare the muscle fiber morphological responses to dynamic electrical muscle stimulation (DEMS) and dynamic hydraulic stimulation (DHS) in rats under hindlimb suspension (HLS). DEMS at 1 Hz, 50 Hz and 100 Hz for 10 min/day, 5 days/week were introduced to the animals' right quadriceps. Static a...

journal_title：Physiological research

authors： Hu M,Lam H,Yeh R,Teeratananon M,Qin YX

更新日期：2017-07-18 00:00:00

abstract：:The present study was designed to measure interstitial levels of norepinephrine-regulating lipolysis (NE) in subcutaneous abdominal adipose tissue of anorexia nervosa (AN) patients and control subjects under basal conditions and after the local administration of an inhibitor of NE re-uptake, maprotiline. In vivo micro...

journal_title：Physiological research

authors： Nedvídková J,Dostálová I,Barták V,Papezov H,Pacák K

更新日期：2004-01-01 00:00:00

abstract：:Methylphenidate is commonly used for the treatment of attention deficit hyperactivity disorder. The cardiovascular safety of methylphenidate has been a subject of debate with some studies indicating that methylphenidate increases the likelihood of experiencing a myocardial infarction. However, it is unknown whether me...

journal_title：Physiological research

authors： Seeley SL,D'Souza MS,Stoops TS,Rorabaugh BR

更新日期：2020-11-16 00:00:00

abstract：:We investigated the effects of telmisartan, the blocker of angiotensin II receptor 1, on the regulation of systolic blood pressure (SBP) and oxidative stress through endothelial nitric oxide (NO) release in spontaneously hypertensive rats (SHRs). SHRs randomly received placebo, oral feeding of telmisartan (5 mg/kg or ...

journal_title：Physiological research

authors： Xu L,Liu Y

更新日期：2013-01-01 00:00:00

abstract：:We measured plasma concentrations, adipose tissue and placental mRNA expression of hepatokines fetuin A, fetuin B and fibroblast growth factor 21 (FGF21) in 12 healthy pregnant women (P group), 12 pregnant women with gestational diabetes (GDM) and 10 healthy non-pregnant women (N group) to explore their potential role...

journal_title：Physiological research

authors： Šimják P,Cinkajzlová A,Anderlová K,Kloučková J,Kratochvílová H,Lacinová Z,Kaválková P,Krejčí H,Mráz M,Pařízek A,Kršek M,Haluzík M

更新日期：2018-11-28 00:00:00

abstract：:Salivary cortisol reflects the free fraction of serum cortisol. Monitoring salivary cortisol may be a promising alternative method for assessing serum cortisol in some clinical situations. We aimed to compare the reliability of salivary vs. serum cortisol during ACTH test. 84 subjects (mean age 63.2; 24-89 years; n=66...

journal_title：Physiological research

authors： Kosák M,Hána V,Hill M,Simůnková K,Lacinová Z,Kršek M,Marek J

更新日期：2014-01-01 00:00:00

abstract：:Mutations in troponin T (TNNT2) gene represent the important part of currently identified disease-causing mutations in hypertrophic (HCM) and dilated (DCM) cardiomyopathy. The aim of this study was to analyze TNNT2 gene exons in patients with HCM and DCM diagnosis to improve diagnostic and genetic consultancy in affec...

journal_title：Physiological research

authors： Jáchymová M,Muravská A,Paleček T,Kuchynka P,Řeháková H,Magage S,Král A,Zima T,Horký K,Linhart A

更新日期：2012-01-01 00:00:00

abstract：:The goal of this study was to identify small molecular weight compounds that bind to sclerostin using in-silico methods because of the established importance of sclerostin-based therapies for the treatment of disease characterized by low bone mass. The zinc database (Zdb) revealed that nine potential molecules bind to...

journal_title：Physiological research

authors： Muthusamy K,Mohan S,Nagamani S,Kesavan C

更新日期：2016-11-23 00:00:00

abstract：:The lymphatic bioavailability (FL) of diazepam (DZ) and its major metabolite desmethyldiazepam (DDZ) was studied. DZ was administered in intravenous and intraduodenal boluses, and in intravenous infusion in three groups of rats with different total lipid (TL) content in the central lymph. The effect of a) different li...

journal_title：Physiological research

authors： Lamka J,Jindrová O

更新日期：1996-01-01 00:00:00

abstract：:This study aimed to examine relationships between DHEA(S), anthropometric parameters, oral glucose tolerance test derived data and lipid spectra in a Czech non-diabetic population. 380 healthy volunteers both with and without a family history of diabetes type 2 (DM2) were enrolled into the study (women: n=235, age 28....

journal_title：Physiological research

authors： Bendlová B,Vrbíková J,Hill M,Vanková M,Lukásová P,Vcelák J,Vejrazková D,Dvoráková K,Hampl R,Vondra K,Stárka L

更新日期：2008-01-01 00:00:00

abstract：:At present, there are insufficient information about baroreflex sensitivity (BRS) and factors that determine BRS in premature newborns. The objective of this study was to determine the relationship between BRS and the characteristics that reflecting the intrauterine development (gestational age and birth weight), as w...

journal_title：Physiological research

authors： Haskova K,Javorka M,Czippelova B,Zibolen M,Javorka K

更新日期：2017-09-22 00:00:00

abstract：:We investigated the influence of oxygenation of in vitro lung preparation on the pulmonary vascular reactivity. Small pulmonary vessels isolated from adult male Wistar rats exposed for 4 days to hypoxia (F(iO2) = 0.1, group CH) were compared with those of normoxic controls (group N). The bath in the chamber of small v...

journal_title：Physiological research

authors： Zaloudíková M,Vízek M,Herget J

更新日期：2009-01-01 00:00:00