Abstract:
:The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. Keap1-Nrf2-ARE system regulates a great set of detoxificant and antioxidant enzymes in cells after ROS and electrophiles exposure. In this review we focus on radical-generating systems in cardiovascular system as well as on Nrf2 as a target against oxidative stress and a key player of redox regulation in cardiovascular diseases. We also summarize the current knowledge about the role of Nrf2 in pathophysiology of several CVD (hypertension, cardiac hypertrophy, cardiomyopathies) as well as in cardioprotection against myocardial ischemia/ reperfusion injury.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Barančík M,Grešová L,Barteková M,Dovinová Idoi
10.33549/physiolres.933403subject
Has Abstractpub_date
2016-09-19 00:00:00pages
S1-S10eissn
0862-8408issn
1802-9973pii
933403journal_volume
65 Suppl 1pub_type
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journal_title:Physiological research
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doi:
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