Influence of hypergravity on the pH profile and proteolytic activity of the avian gastrointestinal tract.

Abstract:

:The present study deals with the effect of hypergravity (2xg) on the pH and on the proteolytic activity in the digesta of the gastrointestinal tract of Japanese quails during intense growth. The birds were raised on a semisynthetic diet containing free amino acids (A) and a commercial diet (B). During days 35 till 40 post-hatching the quails were exposed to hypergravity (2xg) using a specially designed centrifuge. On days 40 (experimental group, 2xg) and 41 (control group, 1xg) the animals were sacrificed. The pH of the digesta in various segments of the gastrointestinal tract was measured by means of a semi-microelectrode. Total proteolytic activity was determined by means of azo-dye-modified proteins serving as general proteolytic substrates. Hypergravity leads in general to an alkalization of digesta in various parts of the gastrointestinal tract. In case of the gizzard and duodenum (diet A) and also in the distal jejunum (diet B) the differences are significant. With both diets, hypergravity leads to a considerable decrease in the total proteolytic activity. The reduction is most expressed in the duodenum and jejunum. Changes in the pH of digesta compensate for the decrease in the proteolytic activity. This may explain why hypergravity per se does not seem to impair growth of the Japanese quails.

journal_name

Physiol Res

journal_title

Physiological research

authors

Rehák M,Snejdárková M,Otto M

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

333-7

issue

3

eissn

0862-8408

issn

1802-9973

journal_volume

40

pub_type

杂志文章
  • Mitochondrial phospholipase A2 activated by reactive oxygen species in heart mitochondria induces mild uncoupling.

    abstract::Homeostasis of reactive oxygen species (ROS) in cardiomyocytes is critical for elucidation of normal heart physiology and pathology. Mitochondrial phospholipases A2 (mt-PLA2) have been previously suggested to be activated by ROS. Therefore, we have attempted to elucidate physiological role of such activation. We have ...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Ježek J,Jabůrek M,Zelenka J,Ježek P

    更新日期:2010-01-01 00:00:00

  • Impact of variants within seven candidate genes on statin treatment efficacy.

    abstract::Statins are the most commonly used drugs in patients with dyslipidemia. Among the patients, a significant inter-individual variability with supposed strong genetic background in statin treatment efficacy has been observed. Genome wide screenings detected variants within the CELSR2/PSRC1/SORT1, CILP2/PBX4, APOB, APOE/C...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932341

    authors: Vrablík M,Hubáček JA,Dlouhá D,Lánská V,Rynekrová J,Zlatohlávek L,Prusíková M,Ceška R,Adámková V

    更新日期:2012-01-01 00:00:00

  • The role of adrenergic agonists on glycogenolysis in rat hepatocyte cultures and possible involvement of NO.

    abstract::Certain liver metabolic diseases point to the presence of disturbances in glycogen deposition. Epinephrine raises the cAMP level that activates protein kinase A leading to the activation of phosphorylase and glycogen breakdown. In the present report, we sought to investigate whether NO is produced during adrenoceptor ...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Hodis J,Kutinová-Canová N,Potmesil P,Kameníková L,Kmonícková E,Zídek Z,Farghali H

    更新日期:2007-01-01 00:00:00

  • In vitro glycosidation potential towards olomoucine-type cyclin-dependent kinase inhibitors in rodent and primate microsomes.

    abstract::Interspecies differences in glycosidation potential in mammalian tissues represent a factor contributing to ambiguity when endobiotic and/or xenobiotic metabolic pathways are extrapolated from animals to man. Using the TLC/autoradiographic technique, we conducted an in vitro investigation involving mouse, rat, monkey,...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Cervenková K,Belejová M,Chmela Z,Rypka M,Riegrová D,Michnová K,Michalíková K,Súrová I,Brejcha A,Hanus J,Cerný B,Fuksová K,Havlícek L,Veselý J

    更新日期:2003-01-01 00:00:00

  • Radioprotective efficacy of dipyridamole and AMP combination in fractionated radiation regimen, and its dependence on the time of administration of the drugs prior to irradiation.

    abstract::We have recently demonstrated that the combined administration of dipyridamole and adenosine monophospate to mice induces radioprotective effects in terms of postirradiation haemopoietic recovery in animals irradiated with a single dose. The aim of the present experiments was to investigate the radioprotective ability...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Hofer M,Pospísil M,Netíková J,Znojil V,Vácha J,Holá J

    更新日期:1995-01-01 00:00:00

  • The effect of HT-2 toxin on ovarian steroidogenesis and its response to IGF-I, leptin and ghrelin in rabbits.

    abstract::T-2 toxin and its metabolite HT-2 toxin are one of the most toxic mycotoxins of type A-trichothecenes, which are produced mainly by Fusarium species. Therefore, study of Fusarium toxins T-2 toxin and HT-2 toxin is an essential issue because they could also play role in failures of reproductive functions as well as end...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.933610

    authors: Kolesarova A,Maruniakova N,Kadasi A,Halenar M,Marak M,Sirotkin AV

    更新日期:2017-09-22 00:00:00

  • Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae.

    abstract::In this study we investigated the effect of beta-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 microg of glucan by i.p. route, were assayed. In v...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Pelizon AC,Kaneno R,Soares AM,Meira DA,Sartori A

    更新日期:2005-01-01 00:00:00

  • Two-phase response of rat pineal melatonin to lethal whole-body irradiation with gamma rays.

    abstract::Male Wistar rats adapted to artificial light:dark (LD) regimen 12:12 h were whole-body irradiated with a single dose of 9.6 Gy of gamma rays and sham/irradiated in the night in darkness. The rats were examined 60 min, 1, 3 and 5 days after exposure between 22:00 and 01:30 h in the darkness. The results obtained indica...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Kassayová M,Ahlersová E,Ahlers I

    更新日期:1999-01-01 00:00:00

  • Moderate alcohol consumption and triglyceridemia.

    abstract::The review aims to summarize current knowledge on the effects of moderate alcohol consumption (1 standard drink a day for women; 2 drinks a day for men) on triglyceride concentration in circulation. Current evidence suggests that the relationship between alcohol consumption and triglyceridemia is J-shaped. Triglycerid...

    journal_title:Physiological research

    pub_type: 杂志文章,评审

    doi:10.33549/physiolres.933178

    authors: Kovář J,Zemánková K

    更新日期:2015-01-01 00:00:00

  • Effects of SERCA and PMCA inhibitors on the survival of rat cochlear hair cells during ischemia in vitro.

    abstract::An important mechanism underlying cochlear hair cell (HC) susceptibility to hypoxia/ischemia is the influx of Ca(2+). Two main ATP-dependent mechanisms contribute to maintaining low Ca(2+) levels: uptake of Ca(2+) into intracellular stores via smooth endoplasmic reticulum calcium ATPase (SERCA) and extrusion of Ca(2+)...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Amarjargal N,Mazurek B,Haupt H,Andreeva N,Fuchs J,Gross J

    更新日期:2008-01-01 00:00:00

  • Yet another decennium of the Institute of Physiology: a dynamic interplay of innovative approaches and 60 years of tradition.

    abstract::I am pleased to introduce this special issue of Physiological Research published on the occasion of the 60th anniversary of the Institute of Physiology. It is only a second issue of this kind, the previous one being Physiological Research 53 (Suppl. 1) 2004. Since then, the Institute contributed its expertise to moder...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Kubínová L

    更新日期:2014-01-01 00:00:00

  • Subdiabetogenic streptozocin treatment impairs preimplantation development of mouse embryos.

    abstract::To estimate the significance of insulin in the regulation of preimplantation embryo growth, female mice received a single subdiabetogenic dose of streptozocin (65 mg/kg intraperitoneally) 8-11 days or 14-17 days before fertilization. Mean glycaemia levels and the number of embryos per mouse did not differ significantl...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Veselá J,Rehák P,Baran V,Koppel J

    更新日期:1993-01-01 00:00:00

  • Blood vessel replacement: 50 years of development and tissue engineering paradigms in vascular surgery.

    abstract::The gold standard material in bypass surgery of blood vessels remains the patient's own artery or vein. However, this material may be unavailable, or may suffer vein graft disease. Currently available vascular prostheses, namely polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE), per...

    journal_title:Physiological research

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Chlupác J,Filová E,Bacáková L

    更新日期:2009-01-01 00:00:00

  • Hormonal aspects of the muscle-bone unit.

    abstract::Osteoporotic fractures are the result of low density and especially inferior bone quality (microarchitecture) caused by both internal (genes, hormones) and external (life style) influences. Bone mechanosensors are extremely important for the overall integrity of the skeleton, because in response to mechanical load the...

    journal_title:Physiological research

    pub_type: 杂志文章,评审

    doi:

    authors: Zofková I

    更新日期:2008-01-01 00:00:00

  • Is severe pulmonary hypertension a contraindication for orthotopic heart transplantation? Not any more.

    abstract::Pulmonary hypertension (PH) unresponsive to pharmacological intervention is considered a contraindication for orthotopic heart transplantation (OHTX) due to risk of postoperative right-heart failure. In this prospective study, we describe our experience with a treatment strategy of improving severe PH in heart transpl...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932158

    authors: Kettner J,Dorazilová Z,Netuka I,Malý J,Al-Hiti H,Melenovský V,Skalský I,Říha H,Málek I,Kautzner J,Pirk J

    更新日期:2011-01-01 00:00:00

  • Natural postmenopause is associated with an increase in combined cardiovascular risk factors.

    abstract::Cardiovascular disease, while rare in women of reproductive age, is the main cause of mortality in menopause. The purpose of our study was to determine the association of natural menopause with cardiovascular risk factors, including their clustering into metabolic syndrome (MS). A random 5 % representative population ...

    journal_title:Physiological research

    pub_type: 杂志文章,随机对照试验

    doi:10.33549/physiolres.932313

    authors: Lejsková M,Alušík S,Valenta Z,Adámková S,Piťha J

    更新日期:2012-01-01 00:00:00

  • Aquaporin expression in the fetal porcine urinary tract changes during gestation.

    abstract::The expression of aquaporins (AQPs) in the fetal porcine urinary tract and its relation to gestational age has not been established. Tissue samples from the renal pelvis, ureter, bladder and urethra were obtained from porcine fetuses. Samples were examined by RT-PCR (AQPs 1-11), QPCR (AQPs positive on RT-PCR), and imm...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.933545

    authors: Jakobsen LK,Trelborg KF,Kingo PS,Hoyer S,Andersson KE,Djurhuus JC,Norregaard R,Olsen LH

    更新日期:2018-05-04 00:00:00

  • Influence of dietary sesamin, a bioactive compound on fatty acids and expression of some lipid regulating genes in Baltic Atlantic salmon (Salmo salar L.) juveniles.

    abstract::The effects of inclusion of sesamin / episesamin in Baltic Atlantic salmon (Salmo salar L.) diets based on vegetable oils were studied. The study was designed as a dose response study with two control diets, one diet based on fish oil (FO) and one diet based on a mixture of linseed and sunflower oil (6:4 by vol.) (MO)...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932068

    authors: Trattner S,Ruyter B,Ostbye TK,Kamal-Eldin A,Moazzami A,Pan J,Gjoen T,Brännäs E,Zlabek V,Pickova J

    更新日期:2011-01-01 00:00:00

  • Rat submandibular gland during the maturation process: changes in enzyme activities, protein and lectin-binding profiles.

    abstract::The total protein glycosylation profile and specific activity of lysosomal enzymes were investigated in rat submandibular glands isolated from very young (1-month), young (1.5-months) and adult rats (3-months) rats. The specific activity of lysosomal hydrolases (i.e. acid phosphatase, arylsulfatases A and B, beta-N-ac...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Przybyło M,Lityńska A,Hoja-Łukowicz D,Kremser E

    更新日期:2004-01-01 00:00:00

  • Epigenetics and a new look on metabolic syndrome.

    abstract::The incidence of metabolic syndrome increases in the developed countries, therefore biomedical research is focused on the understanding of its etiology. The study of exact mechanisms is very complicated because both genetic and environmental factors contribute to this complex disease. The ability of environmental fact...

    journal_title:Physiological research

    pub_type: 杂志文章,评审

    doi:10.33549/physiolres.933174

    authors: Kuneš J,Vaněčková I,Mikulášková B,Behuliak M,Maletínská L,Zicha J

    更新日期:2015-01-01 00:00:00

  • Positive effects of different drug forms of silybin in the treatment of metabolic syndrome.

    abstract::Silymarin and silybin are widely used for their hepatoprotective properties. Our previous studies confirm positive effect of silymarin on lipoprotein profile and lipid homeostasis. Advanced drug forms may improve the bioavailability of these compounds. In this study, we investigate the effects of silybin in different ...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.933235

    authors: Poruba M,Matušková Z,Kazdová L,Oliyarnyk O,Malínská H,Tozzi di Angelo I,Večeřa R

    更新日期:2015-01-01 00:00:00

  • The role of PPARgamma in cardiovascular diseases.

    abstract::The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear superfamily of ligand-activated transcription factors. PPARgamma acts as a nutrient sensor that regulates several homeostatic functions. Its disruption can lead to vascular pathologies, disorders of fatty acid/lipid metabolism and insulin res...

    journal_title:Physiological research

    pub_type: 杂志文章,评审

    doi:10.33549/physiolres.933439

    authors: Kvandová M,Majzúnová M,Dovinová I

    更新日期:2016-10-24 00:00:00

  • The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications.

    abstract::The overproduction of the free radical nitric oxide (NO) by activated immunocompetent cells with subsequent development of local oxidative stress is supposed to be one of the possible pathophysiological mechanisms of beta-cell damage during streptozotocin-induced diabetes. The blockade of increased NO production by si...

    journal_title:Physiological research

    pub_type: 杂志文章,评审

    doi:

    authors: Haluzík M,Nedvídková J

    更新日期:2000-01-01 00:00:00

  • Mitochondrial uncoupling proteins--facts and fantasies.

    abstract::Instead of a comprehensive review, we describe the basic undisputed facts and a modest contribution of our group to the fascinating area of the research on mitochondrial uncoupling proteins. After defining the terms uncoupling, leak, protein-mediated uncoupling, we discuss the assumption that due to their low abundanc...

    journal_title:Physiological research

    pub_type: 杂志文章,评审

    doi:

    authors: Jezek P,Zácková M,Růzicka M,Skobisová E,Jabůrek M

    更新日期:2004-01-01 00:00:00

  • Various aspects of sex and gender bias in biomedical research.

    abstract::The main role of research in medicine is to provide relevant knowledge which, after successful translation to clinical practice, improves the quality of healthcare. The sex bias which is still present in the majority of research disciplines prefers male subjects despite legislation changes in the US grant agencies and...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.934593

    authors: Plevkova J,Brozmanova M,Harsanyiova J,Sterusky M,Honetschlager J,Buday T

    更新日期:2020-12-31 00:00:00

  • Endothelin and diabetic complications: a brain-centric view.

    abstract::The global epidemic of diabetes is of significant concern. Diabetes associated vascular disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also the most rapidly increasing risk factor for cognitive impairment, a silent disease that causes loss of creativity, productivity, and ...

    journal_title:Physiological research

    pub_type: 杂志文章,评审

    doi:10.33549/physiolres.933833

    authors: Li W,Abdul Y,Ward R,Ergul A

    更新日期:2018-06-27 00:00:00

  • Rooibos tea (Aspalathus linearis) partially prevents oxidative stress in streptozotocin-induced diabetic rats.

    abstract::The aim of this study was to investigate the effects of rooibos tea as a natural source of a wide scale of antioxidants on the prevention and treatment of oxidative stress in streptozotocin-induced diabetic rats. Expected significant changes of biochemical parameters characteristic for experimental diabetic state were...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Ulicná O,Vancová O,Bozek P,Cársky J,Sebeková K,Boor P,Nakano M,Greksák M

    更新日期:2006-01-01 00:00:00

  • Different functional responsibility of the small intestine to high-fat/high-energy diet determined the expression of obesity-prone and obesity-resistant phenotypes in rats.

    abstract::The objective of the present experiment was to assess the involvement of small intestine in expression of susceptibility or resistance to the high-fat/high-energy diet. The investigation was carried out in adult male Sprague-Dawley rats fed either standard laboratory diet (3.2 kcal/g, 9.5 % fat) or high-fat (HF) diet ...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Sefcíková Z,Hájek T,Lenhardt L,Racek L,Mozes S

    更新日期:2008-01-01 00:00:00

  • The effect of goldthioglucose on peroxidative processes in mice.

    abstract::Experiments were conducted to study the effect of goldthioglucose (GTG) upon the processes associated with lipid peroxidation. The glucose-6-phosphate dehydrogenase activity (G6PD; E.C. 1. 1.1.49) in red blood cells (RBC) and the amount of malonaldehyde precursors (MDA) per gram of brain, liver and kidney were determi...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Kostová D,Michnová E

    更新日期:1999-01-01 00:00:00

  • Erythrocyte omega-3, omega-6 and trans fatty acids in relation to risk of preeclampsia among women delivering at Harare Maternity Hospital, Zimbabwe.

    abstract::We sought to examine the association between maternal erythrocyte omega-3, omega-6 and trans fatty acids and risk of preeclampsia. We conducted a case-control study of 170 women with proteinuric, pregnancy-induced hypertension and 185 normotensive pregnant women who delivered at Harare Maternity Hospital, Harare, Zimb...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Mahomed K,Williams MA,King IB,Mudzamiri S,Woelk GB

    更新日期:2007-01-01 00:00:00