Abstract:
:The pathological potential of glial cells was recognized already by Rudolf Virchow, Santiago Ramon y Cajal and Pio Del Rio-Ortega. Many functions and roles performed by astroglia in the healthy brain determine their involvement in brain diseases; as indeed any kind of brain insult does affect astrocytes, and their performance in pathological conditions, to a very large extent, determines the survival of the brain parenchyma, the degree of damage and neurological defect. Astrocytes being in general responsible for overall brain homeostasis are involved in virtually every form of brain pathology. Here we provide an overview of recent developments in identifying the role and mechanisms of the pathological potential of astroglia.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Chvátal A,Anderová M,Neprasová H,Prajerová I,Benesová J,Butenko O,Verkhratsky Asubject
Has Abstractpub_date
2008-01-01 00:00:00pages
S101-10eissn
0862-8408issn
1802-9973pii
1604journal_volume
57 Suppl 3pub_type
杂志文章,评审abstract::Osteoporotic fractures are the result of low density and especially inferior bone quality (microarchitecture) caused by both internal (genes, hormones) and external (life style) influences. Bone mechanosensors are extremely important for the overall integrity of the skeleton, because in response to mechanical load the...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract::The gold standard material in bypass surgery of blood vessels remains the patient's own artery or vein. However, this material may be unavailable, or may suffer vein graft disease. Currently available vascular prostheses, namely polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE), per...
journal_title:Physiological research
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.932524
更新日期:2014-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.932811
更新日期:2015-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.932994
更新日期:2016-06-20 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.933890
更新日期:2018-11-14 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.933545
更新日期:2018-05-04 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.934300
更新日期:2019-11-30 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章,评审
doi:10.33549/physiolres.932080
更新日期:2011-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::The frequencies of the alleles of XbaI polymorphism in the apolipoprotein B gene were determined in two groups of children, 82 with high (HCG) and 86 with low (LCG) cholesterol levels. A slightly higher incidence of the X2X2 genotype in HCG was found, but the differences were not statistically significant. No relation...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Adaptation to intermittent high altitude hypoxia (IHAH) increases tolerance of the isolated neonatal rat heart to ischemia and potentiates protection induced by ischemic preconditioning. In addition to the protective effect, IHAH significantly reduces growth of the animals. The aim of the present study was, therefore,...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Slow breathing training reduces resting blood pressure, probably by modifying central autonomic control, but evidence for this is lacking. The pressor response to static handgrip exercise is a measure of autonomic control and the aim of this study was to determine whether slow breathing training modulates the pressor ...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.932950
更新日期:2015-01-01 00:00:00
abstract::The effects of selenium (Se) on antioxidant defense system in liver and kidneys of rats with cadmium (Cd)-induced toxicity were examined. Cd exposure (15 mg Cd/kg b.m./day as CdCl(2) for 4 weeks) resulted in increased lipid peroxidation (LP) in both organs (p<0.005 and p<0.01). Vitamin C (Vit C) was decreased in the l...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Vascular stenosis is often described only by its percentage in both clinical and scientific praxis. Previous studies gave inconclusive results regarding the effect of stenosis eccentricity on its hemodynamic effect. The aim of this experimental study was to investigate and quantify the effect of stenosis severity and ...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.932944
更新日期:2016-01-01 00:00:00
abstract::The role of the cortico-tectal pathways in the processing of auditory signals was investigated by recording the click-evoked responses and extracellular multiple unit activity in the inferior colliculus (IC) after functional ablation of the auditory cortex (AC) by local intracortical application of a sodium channel bl...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The mitochondrial DNA (mtDNA) amount in cells as the basis for mitochondrial energy generating system, which produces ATP, plays an important role in the fetal development and postnatal morbidity. Isolated human cord blood leukocytes (HCBL) contribute very little to the overall metabolic turnover, but they may serve a...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Evaluation of possible interactions with enzymes of drug metabolism is an important part of studies on safety and, in general, on the properties of any drug or biologically active compound. Here, focus is given on interactions of three sesquiterpenes (beta-caryophyllene oxide (CAO), trans-nerolidol (tNER) and farnesol...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.934323
更新日期:2019-11-22 00:00:00
abstract::Impaired cerebrovascular reactivity (CVR), an important risk factor for future stroke, is affected by a presence carotid stenosis. However, in some cases CVR can be impaired in the absence of carotid stenosis due to several poorly characterized mechanisms. We hypothesized that arterial stiffening as observed in corona...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.932837
更新日期:2015-01-01 00:00:00
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journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The aim of this study was to assess carotid baroreflex responses during graded lower body negative pressure (LBNP). In 12 healthy subjects (age 29+/-4 years) we applied sinusoidal neck suction (0 to -30 mmHg) at 0.1 Hz to examine the sympathetic modulation of the heart and blood vessels and at 0.2 Hz to assess the eff...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Ferritin and increased iron stores first appeared on the list of cardiovascular risk factors more than 30 years ago and their causal role in the pathogenesis of atherosclerosis has been heavily discussed since the early 1990s. It seems that besides traditional factors such as hyperlipoproteinemia, hypertension, diabet...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:10.33549/physiolres.933589
更新日期:2017-04-05 00:00:00
abstract::The aim of this study was to assess the molecular basis of renal Na,K-ATPase disturbances in response to NO-deficient hypertension induced in rats by NO-synthase inhibition with 40 mg/kg/day N(G)-nitro-L-arginine methyl ester (L-NAME) for four weeks. After 4-week administration of L-NAME, the systolic blood pressure (...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The purpose of this study was to investigate plasma concentrations of cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) during and after real and simulated space flight. Venous blood was obtained 3 min after the beginning and 2 min after the lower body negative pressure maneuver in two cosmona...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. ...
journal_title:Physiological research
pub_type: 杂志文章,评审
doi:10.33549/physiolres.933403
更新日期:2016-09-19 00:00:00
abstract::We used a rat model to assess the role of nephrin, podocin, and desmin in the pathogenesis of IgA nephropathy (IgAN). A rat IgAN model was established by administration of BSA, CCl(4), and lipopolysaccharide (LPS) and compared with healthy control rats. Urinary protein, urine red blood cells, and biochemical parameter...
journal_title:Physiological research
pub_type: 杂志文章
doi:10.33549/physiolres.932380
更新日期:2013-01-01 00:00:00
abstract::A total genome scan and pharmacogenetic study were designed to search for genetic determinants of blood pressure (BP) as well as heart and kidney weights. Genome scanning was carried out in 266 F(2) intercrosses from Prague hypertensive hypertriglyceridemic rats for phenotypes of organ weights, baseline BP, BP after b...
journal_title:Physiological research
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00