Abstract：
:D-galactosamine is a hepatotoxic agent, which induces diffuse injury of liver tissue followed by the regeneration process. Our data showed a high increase of serum aminotransferases after D-galactosamine administration, which indicates a high extent of liver injury. When lipid emulsion was applied immediately after D-galactosamine, the increase of serum aminotransferases was greatly reduced. In addition, the decrease of the cytochrome c oxidase activity induced by D-galactosamine was not observed after lipid emulsion administration and the increase of total liver oxidative capacity in the regeneration period due to activated mitochondrial biogenesis was accelerated. All these findings indicate a protective effect of lipid emulsion administration against D-galactosamine toxicity.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Ferencíková R,Cervinková Z,Drahota Zsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
73-8issue
1eissn
0862-8408issn
1802-9973journal_volume
52pub_type
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