Influence of beta-resorcylidene aminoguanidine on selected metabolic parameters and antioxidant status of rats with diabetes mellitus.

abstract：:Young intact (18 days of age) and adult ovariectomized (OV-X, ovariectomized between 21 to 24 days of age) C3H/Di mice were used to measure the estrogenicity on the basis of the growth response of mammary epithelial structures and weight of the uterus. The percentage area of the mammary fat pad occupied by mammary epi...

journal_title：Physiological research

authors： Skarda J

更新日期：2002-01-01 00:00:00

abstract：:To compare circulating pigment epithelium derived factor (PEDF) levels in type 2 diabetes patients (T2D) with and without metabolic syndrome (MetS+/-) to healthy controls and assess PEDF association with plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF) as markers of endothelial dysfunction. Fi...

journal_title：Physiological research

authors： Karasek D,Spurna J,Kubickova V,Krystynik O,Cibickova L,Schovanek J,Goldmannova D

更新日期：2019-06-30 00:00:00

abstract：:Photodynamic therapy (PDT) is now being used more frequently in carefully selected cases of malignancies. The drugs used for PDT are mostly derivatives of haematoporphyrine (HPD) and its active component photofrine II. Another compound prepared by total synthesis is meso-tetra-(4-sulfonatophenyl)-porphine (TPPS4) but ...

journal_title：Physiological research

authors： Zima T,Jirsa M,Jirsa M Jr,Bradová V,Stejskal J,Zabka J,Povýsil C,Janebová M

更新日期：1997-01-01 00:00:00

abstract：:Kainic acid (KA) is a potent neurotoxic substance valuable in research of temporal lobe epilepsy. We tested how subconvulsive dose of KA influences spontaneous behavior of adult Wistar rats. Animals were treated with 5 mg/kg of KA and tested in Laboras open field test for one hour in order to evaluate various behavior...

journal_title：Physiological research

authors： Riljak V,Marešová D,Pokorný J,Jandová K

更新日期：2015-01-01 00:00:00

abstract：:Stomach lesions induced by indomethacin (20 mg.kg-1 i.p.) and ethanol (1 ml 95% intragastrically) were studied after a 24 hour fast in rats which had undergone sialoadenectomy. The size of the lesions was correlated with gastric HCl secretion, with gastric vascular permeability (determined from the Evans blue concentr...

journal_title：Physiological research

authors： Kohút A,Maheĺová O,Mojzís J,Mirossay L

更新日期：1992-01-01 00:00:00

abstract：:In this retrospective study we analysed changes of the ST segment in patients with arterial hypertension using multi-lead body surface mapping of the electric heart field as the ST segment often shows non-specific changes and is influenced by many different conditions. We constructed isointegral maps (IIM) of chosen i...

journal_title：Physiological research

authors： Kozlíková K,Martinka J,Bulas J

更新日期：2012-01-01 00:00:00

abstract：:In this report, we dealt with ventricular activation abnormalities in 30 patients with previous non-Q myocardial infarction (MI) by means of the CARDIAG 128.1 device, which enables analysis of ECGs, VCGs and body surface potential maps. The diagnosis was verified by left ventriculography, echocardiography and perfusio...

journal_title：Physiological research

authors： Stovícek P,Stojan M,Kasalický J,Vondrácek V,Vojácek J,Linhart A,Anger Z

更新日期：1993-01-01 00:00:00

abstract：:Dihydrotestosterone (DHT) originates via irreversible reduction of testosterone by catalytic activity of 5alpha-reductase enzyme and it is demonstratively the most effective androgen. Androgens influence adipose tissue in men either directly by stimulation of the androgen receptor or indirectly, after aromatization, b...

journal_title：Physiological research

authors： Dušková M,Pospíšilová H

更新日期：2011-01-01 00:00:00

abstract：:The presence of insulin resistance is frequently found in essential hypertension. There are, however, only sparse data with respect to the potential presence of insulin resistance in patients with secondary hypertension. We have therefore undertaken a study to reveal the potential occurrence of insulin resistance in p...

journal_title：Physiological research

authors： Widimský J Jr,Sindelka G,Haas T,Prázný M,Hilgertová J,Skrha J

更新日期：2000-01-01 00:00:00

abstract：:Rat skeletal muscle myofibrils were incubated in the presence of D-glucose, D-fructose, D-galactose, D-ribose, D-tagatose, D-arabinose, D-xylose, D-mannose, L-sorbose, L-rhamnose or DL-glyceraldehyde and myofibrillar ATPase activity as well as the extent of glycation was measured. The attachment of sugars to proteins ...

journal_title：Physiological research

authors： Syrový I

更新日期：1994-01-01 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) has proven efficacious in reducing or even eliminating cardiac dyssynchrony and thus improving heart failure symptoms. However, quantification of mechanical dyssynchrony is still difficult and identification of CRT candidates is currently based just on the morphology and width o...

journal_title：Physiological research

authors： Kittnar O,Riedlbauchová L,Tomis J,LoŽek M,Valeriánová A,Hrachovina M,Mlček M,Huptych M,Janoušek J,Lhotská L

更新日期：2017-12-30 00:00:00

abstract：:Electrophysiological studies of whole organ systems in vitro often require measurement of nerve activity and/or stimulation of the organ via the associated nerves. Currently two-compartment setups are used for such studies. These setups are complicated and require two fluids in two separate compartments and stretching...

journal_title：Physiological research

authors： Choudhary M,Clavica F,van Mastrigt R,van Asselt E

更新日期：2016-06-20 00:00:00

abstract：:It is believed that omentin is secreted by stromal cells of adipose tissue and modulates insulin sensitivity. Data from a few studies have shown lower serum omentin in obese children and higher in anorexia nervosa. However, to date, there is lack of research on serum omentin concentrations in adolescent patients in a ...

journal_title：Physiological research

authors： Oświęcimska J,Suwała A,Świętochowska E,Ostrowska Z,Gorczyca P,Ziora-Jakutowicz K,Machura E,Szczepańska M,Kukla M,Stojewska M,Ziora D,Ziora K

更新日期：2015-01-01 00:00:00

abstract：:Chronic kidney disease adversely affects the structure and metabolism of bone tissue, which may be a result of disturbed biochemical processes in adipose tissue. Renal replacement therapy is a life-saving therapy but it does not restore all metabolic functions and sometimes even escalates some disturbances. The study ...

journal_title：Physiological research

authors： Marchelek-Myśliwiec M,Dziedziejko V,Nowosiad-Magda M,Wiśniewska M,Safranow K,Pawlik A,Domański L,Dołęgowska K,Dołęgowska B,Stępniewska J,Ciechanowski K

更新日期：2019-12-30 00:00:00

abstract：:Epoxyeicosatrienoic acids (EETs) are also known as epoxyeicosanoids that have renal and cardiovascular actions. These renal and cardiovascular actions can be regulated by soluble epoxide hydrolase (sEH) that degrades and inactivates EETs. Extensive animal hypertension studies have determined that vascular, epithelial ...

journal_title：Physiological research

authors： Imig JD

更新日期：2019-10-25 00:00:00

abstract：:The effects of inclusion of sesamin / episesamin in Baltic Atlantic salmon (Salmo salar L.) diets based on vegetable oils were studied. The study was designed as a dose response study with two control diets, one diet based on fish oil (FO) and one diet based on a mixture of linseed and sunflower oil (6:4 by vol.) (MO)...

journal_title：Physiological research

authors： Trattner S,Ruyter B,Ostbye TK,Kamal-Eldin A,Moazzami A,Pan J,Gjoen T,Brännäs E,Zlabek V,Pickova J

更新日期：2011-01-01 00:00:00

abstract：:The aim of the present work was to investigate a new mechanism likely contributing to the toxic action of acetaminophen, especially to explore the possible inhibition of glutathione reductase through an acetaminophen-glutathione conjugate (APAP-SG). APAP-SG conjugate was synthesized by organic synthesis and purified b...

journal_title：Physiological research

authors： Rousar T,Pařík P,Kucera O,Bartos M,Červinková Z

更新日期：2010-01-01 00:00:00

abstract：:Quaternary benzo[c]phenanthridine alkaloids (QBA), fagaronine (FA), sanguinarine (SA), chelerythrine (CHE) and the QBA extract from Macleya cordata (EX) exerted differential inhibitory effect on the hydrolytic activity of particular dipeptidyl peptidase (DPP)-like enzyme isolated from human blood plasma and from human...

journal_title：Physiological research

authors： Sedo A,Malík R,Vicar J,Simánek V,Ulrichová J

更新日期：2003-01-01 00:00:00

abstract：:The concept of vena contracta space reduction in tricuspid valve position was tested in an animal model. Feasibility of specific artificial obturator body (REMOT) fixed to the right ventricular apex and interacting with tricuspid valve leaflets was evaluated in three different animal studies. Catheter-based technique ...

journal_title：Physiological research

authors： Sochman J,Peregrin JH,Pavcnik D,Uchida BT,Timmermans HA,Sedmera D,Benada O,Kofronova O,Keller FS,Rosch J

更新日期：2014-01-01 00:00:00

abstract：:Oculometric behaviour assessed by pupil response provides important information about central autonomic activity and emotional regulation. However, studies regarding pupil response to emotional stimuli in adolescent depression are rare. We aimed to study emotional-linked pupil response in adolescent depression. Twenty...

journal_title：Physiological research

authors： Sekaninova N,Ondrejka I,Bona Olexova L,Visnovcova Z,Mestanik M,Cesnekova D,Hamrakova A,Tonhajzerova I

更新日期：2019-12-20 00:00:00

abstract：:Adaptation to intermittent high altitude hypoxia (IHAH) increases tolerance of the isolated neonatal rat heart to ischemia and potentiates protection induced by ischemic preconditioning. In addition to the protective effect, IHAH significantly reduces growth of the animals. The aim of the present study was, therefore,...

journal_title：Physiological research

authors： Chvojková Z,Ostádalová I,Ostádal B

更新日期：2005-01-01 00:00:00

abstract：:Psychostimulants, including methamphetamine (MA), have neurotoxic effect, especially, if they are targeting CNS during its critical periods of development. The present study was aimed to examine cognitive changes after prenatal and neonatal MA treatment in combination with chronic MA exposure in adulthood of male rats...

journal_title：Physiological research

authors： Hrebíčková I,Ševčíková M,Nohejlová K,Šlamberová R

更新日期：2016-12-22 00:00:00

abstract：:Eukaryotic cytochrome c oxidase (CcO), the terminal component of the mitochondrial electron transport chain is a heterooligomeric complex that belongs to the superfamily of heme-copper containing terminal oxidases. The enzyme, composed of both mitochondrially and nuclear encoded subunits, is embedded in the inner mito...

journal_title：Physiological research

authors： Stiburek L,Hansikova H,Tesarova M,Cerna L,Zeman J

更新日期：2006-01-01 00:00:00

abstract：:A new approach to computer modelling of neuronal stochastic activity is described. The output dynamic activity which depends on the types and the number of input synapses, weights of the synaptic efficacy, the absolute refractory phase duration and threshold level is evaluated on this model in some types of Gaussian i...

journal_title：Physiological research

authors： Novák V,Schmidt J

更新日期：1996-01-01 00:00:00

abstract：:A new concept of cardioprotection based on the exploitation of endogenous mechanisms is known as ischemic preconditioning (IPC). It has been hypothesized that substances released during brief ischemic stress (e.g. catecholamines) stimulate the receptors and trigger multiple cell signaling cascades. Opening of ATP-sens...

journal_title：Physiological research

authors： Ravingerová T,Pancza D,Ziegelhoffer A,Styk J

更新日期：2002-01-01 00:00:00

abstract：:For better understanding of pathophysiological processes leading to increased retention of sodium as a consequence of hyperlipidemia, the properties of renal Na,K-ATPase, a key enzyme involved in maintaining sodium homeostasis in the organism, were studied. Enzyme kinetics of renal Na,K-ATPase were used for characteri...

journal_title：Physiological research

authors： Vrbjar N,Mézešová L,Javorková V,Vlkovičová J,Mitašíková M,Dlugošová K,Okruhlicová L,Tribulová N

更新日期：2011-01-01 00:00:00

abstract：:We investigated the influence of oxygenation of in vitro lung preparation on the pulmonary vascular reactivity. Small pulmonary vessels isolated from adult male Wistar rats exposed for 4 days to hypoxia (F(iO2) = 0.1, group CH) were compared with those of normoxic controls (group N). The bath in the chamber of small v...

journal_title：Physiological research

authors： Zaloudíková M,Vízek M,Herget J

更新日期：2009-01-01 00:00:00

abstract：:Gain-of-function (GOF) mutations in ion channels are rare events, which lead to increased agonist sensitivity or altered gating properties, and may render the channel constitutively active. Uncovering and following characterization of such mutants contribute substantially to the understanding of the molecular basis of...

journal_title：Physiological research

authors： Boukalova S,Touska F,Marsakova L,Hynkova A,Sura L,Chvojka S,Dittert I,Vlachova V

更新日期：2014-01-01 00:00:00

abstract：:No data are available about the effects of AT1 receptor antagonist losartan on the skeleton and there is also little information on the activity of an ACE inhibitor enalapril on bone metabolism. It is widely believed that the vasculature plays an important role in bone remodeling under normal and pathological conditio...

journal_title：Physiological research

authors： Broulík PD,Tesar V,Zima T,Jirsa M

更新日期：2001-01-01 00:00:00

abstract：:Metabolic syndrome and one of its manifestations, essential hypertension, is an important cause of worldwide morbidity and mortality. Morbidity and mortality associated with hypertension are caused by organ complications. Previously we revealed a decrease of blood pressure and an amelioration of cardiac fibrosis in a ...

journal_title：Physiological research

authors： Mirchi LF,Chylíková B,Janků M,Šeda O,Liška F

更新日期：2019-10-25 00:00:00