Lack of an association between apolipoprotein B XbaI polymorphism and blood lipid parameters in childhood.

Abstract:

:The frequencies of the alleles of XbaI polymorphism in the apolipoprotein B gene were determined in two groups of children, 82 with high (HCG) and 86 with low (LCG) cholesterol levels. A slightly higher incidence of the X2X2 genotype in HCG was found, but the differences were not statistically significant. No relations were found between the XbaI polymorphic site and the levels of serum lipids and lipoproteins. Common XbaI polymorphism in the apolipoprotein B gene does not determine significantly the plasma cholesterol levels in childhood.

journal_name

Physiol Res

journal_title

Physiological research

authors

Hubácek JA,Pistulková H,Písa Z,Valenta Z,Skodová Z,Poledne R

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

89-93

issue

2

eissn

0862-8408

issn

1802-9973

journal_volume

47

pub_type

杂志文章
  • Adhesion of erythrocytes to endothelial cells after acute exercise: differences in red blood cells from juvenile and adult rats.

    abstract::Erythrocytes (RBC) from untrained male Wistar rats and rat glomerular endothelial cells (EC) were used to investigate the effects of acute exercise (speed: 20 m/min, slope: 0, duration: 1 hour) on RBC membrane protein oxidation and adhesion to cultured EC. Experimental animals were divided into juvenile (age 10 weeks)...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Temiz Artmann A,Akhisaroglu M,Sercan Z,Resmi H,Kayatekin BM,Yorukoglu K,Kirkali G

    更新日期:2006-01-01 00:00:00

  • Effect of block of α-1-adrenoceptors on overall motor activity but not on spatial cognition in the object-position recognition task.

    abstract::Prazosin, an alpha(1)-adrenoceptor antagonist, is well known for its depressant effect on motivation and motor activity, while it has no effect on retention of spatial behavior in several tasks, e.g. in the Morris water maze and radial arm maze. The role of alpha(1)-adrenoceptors in operant tasks with stimulus-control...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932570

    authors: Levčík D,Stuchlík A,Klement D

    更新日期:2013-01-01 00:00:00

  • Postnatal expression of bone morphogenetic proteins and their receptors in the mouse testis.

    abstract::TGF-beta superfamily members including bone morphogenetic proteins (BMPs) and their receptors (BMPR-1A, -1B and -2) have been shown to be important for reproductive function in both males and females, while information on the role of BMPs in males is limited. Functional studies on select BMPs and BMP receptors have de...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.933193

    authors: Ciller IM,Palanisamy SK,Ciller UA,McFarlane JR

    更新日期:2016-11-08 00:00:00

  • ST segment body surface isointegral maps in patients with arterial hypertension.

    abstract::In this retrospective study we analysed changes of the ST segment in patients with arterial hypertension using multi-lead body surface mapping of the electric heart field as the ST segment often shows non-specific changes and is influenced by many different conditions. We constructed isointegral maps (IIM) of chosen i...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932121

    authors: Kozlíková K,Martinka J,Bulas J

    更新日期:2012-01-01 00:00:00

  • Hyperoxia blunts acute hypoxia- and PGF2alpha-induced pulmonary vasoconstriction in chronically hypoxic rats.

    abstract::We investigated the influence of oxygenation of in vitro lung preparation on the pulmonary vascular reactivity. Small pulmonary vessels isolated from adult male Wistar rats exposed for 4 days to hypoxia (F(iO2) = 0.1, group CH) were compared with those of normoxic controls (group N). The bath in the chamber of small v...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Zaloudíková M,Vízek M,Herget J

    更新日期:2009-01-01 00:00:00

  • Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin.

    abstract::Digitonin solubilizes mitochondrial membrane, breaks the integrity of the respiratory chain and releases two mobile redox-active components: coenzyme Q (CoQ) and cytochrome c (cyt c). In the present study we report the inhibition of glycerol-3-phosphate- and succinate-dependent oxygen consumption rates by digitonin tr...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932318

    authors: Rauchová H,Vokurková M,Drahota Z

    更新日期:2012-01-01 00:00:00

  • Preventive effect of L-carnitine on the disorder of lipid metabolism and circadian clock of mice subjected to chronic jet-lag.

    abstract::Circadian clock plays an essential role in orchestrating daily physiology, and its disruption can evoke metabolic diseases such as obesity. L-Carnitine can reduce blood lipid levels, and ameliorate fatty liver through regulating lipid metabolism. However, whether L-Carnitine administration may affect the disturbance o...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.933543

    authors: Xie X,Guo A,Wu T,Hu Q,Huang L,Yao C,Zhao B,Zhang W,Chi B,Lu P,Zhao Z,Fu Z

    更新日期:2017-11-24 00:00:00

  • Differential Urinary Proteomic Analysis of Endometrial Cancer.

    abstract::Endometrial cancer is one of the most frequent gynecological malignancies present in more than 95 % of all uterine cancers. In spite of that, screening of such disease is not commonly performed in clinical practice due to enormous costs and relatively low sensitivity. Therefore, developing an effective screening test ...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.934375

    authors: Kacírová M,Bober P,Alexovič M,Tomková Z,Tkáčiková S,Talian I,Mederová L,Bérešová D,Tóth R,Andrašina I,Kožlejová Z,Kilík R,Divín R,Sabo J

    更新日期:2019-12-30 00:00:00

  • Image analysis of argyrophil nucleolar organizer regions (AgNORs) in oestrogen-induced rat anterior pituitary hyperplasia: comparison of automatized (LUCIA M) and non-automatized evaluation.

    abstract::Argyrophil nucleolar organizer regions (AgNORs) were morphometrically evaluated in rat anterior pituitaries of control and oestrogenized rats using an automatized (LUCIA M--Laboratory Universal Computer Image Analysis Micro) and a non-automatized approaches to investigate not only the sensitivity and effectiveness of ...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Dusková J,Povýsil C,Schreiber V

    更新日期:1995-01-01 00:00:00

  • Analysis of relations between serum levels of epitestosterone, estradiol, testosterone, IGF-1 and prostatic specific antigen in men with benign prostatic hyperplasia and carcinoma of the prostate.

    abstract::Epitestosterone competes with testosterone for androgen receptors and inhibits several enzymes of steroidogenesis. Insulin-like growth factors (IGFs) stimulate the growth of prostate cells and directly activate androgen receptors in prostatic tumor cell lines. The prostate-specific antigen (PSA) decreases the affinity...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Hill M,Bílek R,Safarík L,Stárka L

    更新日期:2000-01-01 00:00:00

  • Crowding-induced alterations in vascular system of Wistar-Kyoto rats: role of nitric oxide.

    abstract::The aim of this study was to determine the effect of chronic crowding on the cardiovascular system of Wistar-Kyoto (WKY) rats. Rats were randomly divided into the control (480 cm(2) per rat) or crowded (200 cm(2) per rat) group for eight weeks. Body weight, blood pressure (BP), heart rate and plasma nitrate/nitrite le...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Bernátová I,Púzserová A,Navarová J,Csizmadiová Z,Zeman M

    更新日期:2007-01-01 00:00:00

  • The effect of chronic morphine or methadone exposure and withdrawal on clock gene expression in the rat suprachiasmatic nucleus and AA-NAT activity in the pineal gland.

    abstract::The circadian rhythms of many behavioral and physiological functions are regulated by the major circadian pacemaker in the suprachiasmatic nucleus. Long-term opiate addiction and drug withdrawal may affect circadian rhythmicity of various hormones or the sleep/activity pattern of many experimental subjects; however, l...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.933183

    authors: Pačesová D,Novotný J,Bendová Z

    更新日期:2016-07-18 00:00:00

  • Downregulation of miR-30c-5p expression in colorectal cancer tissue is sex-dependent.

    abstract::We report that decreased expression of miR-30c in tumor compared to adjacent tissue is sex-dependent in colorectal cancer (CRC) patients. High expression of miR-30c was associated with better survival in the whole cohort. When the cohort was split into male and female subcohorts, decreased miR-30c expression in tumor ...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.934598

    authors: Herichova I,Reis R,Hasakova K,Vician M

    更新日期:2020-12-31 00:00:00

  • Effect of an increase in coronary perfusion on transmural ventricular repolarization.

    abstract::The effect of increased coronary flow on transmural ventricular repolarization was investigated in six pentobabital-anesthetized sheep. Fresh blood at 10 ml/min was injected into the left circumflex coronary artery (LCX) in addition to the normal coronary flow. Unipolar electrocardiograms were simultaneously registere...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Zhang YZ,He B,Wang LX

    更新日期:2007-01-01 00:00:00

  • Novel adipokine fibroblast growth factor 21 is increased in rheumatoid arthritis.

    abstract::Fibroblast growth factor-21 (FGF-21) has been recently characterized as a new adipokine. The aim of this study was to assess FGF-21 levels in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationship between FGF-21, disease activity and metabolic status. The levels of FGF-21 in seru...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932324

    authors: Hulejová H,Andrés Cerezo L,Kuklová M,Pecha O,Vondráček T,Pavelka K,Vencovský J,Haluzík M,Senolt L

    更新日期:2012-01-01 00:00:00

  • Melanocortin-4 receptor gene mutations in obese Slovak children.

    abstract::The most common etiology of non-syndromic monogenic obesity are mutations in gene for the Melanocortin-4 receptor (MC485) with variable prevalence in different countries (1.2-6.3 % of obese children). The aim of our study was 1) to search for MC4R mutations in obese children in Slovakia and compare their prevalence wi...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932968

    authors: Stanikova D,Surova M,Ticha L,Petrasova M,Virgova D,Huckova M,Skopkova M,Lobotkova D,Valentinova L,Mokan M,Stanik J,Klimes I,Gasperikova D

    更新日期:2015-01-01 00:00:00

  • Suramin affects capsaicin responses and capsaicin-noxious heat interactions in rat dorsal root ganglia neurones.

    abstract::The effect of suramin, an inhibitor of G protein regulated signalling, was studied on the membrane currents induced by noxious heat and by capsaicin in cultured dorsal root ganglia neurones isolated from neonatal rats. Whole-cell responses induced by a heat ramp (24-52 degrees C) were little affected by suramin. The n...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Vlachová V,Lyfenko A,Vyklický L,Orkand RK

    更新日期:2002-01-01 00:00:00

  • Glycation of myofibrillar proteins and ATPase activity after incubation with eleven sugars.

    abstract::Rat skeletal muscle myofibrils were incubated in the presence of D-glucose, D-fructose, D-galactose, D-ribose, D-tagatose, D-arabinose, D-xylose, D-mannose, L-sorbose, L-rhamnose or DL-glyceraldehyde and myofibrillar ATPase activity as well as the extent of glycation was measured. The attachment of sugars to proteins ...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Syrový I

    更新日期:1994-01-01 00:00:00

  • Regulation of fetoplacental vascular bed by hypoxia.

    abstract::Important fetal and perinatal pathologies, especially intrauterine growth restriction (IUGR), are thought to stem from placental hypoxia-induced vasoconstriction of the fetoplacental vessels, leading to placental hypoperfusion and thus fetal undernutrition. However, the effects of hypoxia on the fetoplacental vessels ...

    journal_title:Physiological research

    pub_type: 杂志文章,评审

    doi:

    authors: Hampl V,Jakoubek V

    更新日期:2009-01-01 00:00:00

  • Spironolactone differently influences remodeling of the left ventricle and aorta in L-NAME-induced hypertension.

    abstract::Aldosterone receptor antagonist, spironolactone, has been shown to prevent remodeling of the heart in several models of left ventricular hypertrophy. The aim of the present study was to determine whether the treatment with spironolactone can prevent hypertension, reduction of tissue nitric oxide synthase activity and ...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Simko F,Matúsková J,Lupták I,Pincíková T,Krajcírovicová K,Stvrtina S,Pomsár J,Pelouch V,Paulis L,Pechánová O

    更新日期:2007-01-01 00:00:00

  • Silymarin component 2,3-dehydrosilybin attenuates cardiomyocyte damage following hypoxia/reoxygenation by limiting oxidative stress.

    abstract::Ischemic postconditioning and remote conditioning are potentially useful tools for protecting ischemic myocardium. This study tested the hypothesis that 2,3-dehydrosilybin (DHS), a flavonolignan component of Silybum marianum, could attenuate cardiomyocyte damage following hypoxia/reoxygenation by decreasing the genera...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932703

    authors: Gabrielová E,Křen V,Jabůrek M,Modrianský M

    更新日期:2015-01-01 00:00:00

  • Apelin-13 regulates angiotensin ii-induced Cx43 downregulation and autophagy via the AMPK/mTOR signaling pathway in HL-1 cells.

    abstract::Atrial fibrillation is associated with atrial remodeling, in which connexin 43 (Cx43) and cell hypertrophy play important roles. In this study, apelin-13, an aliphatic peptide, was used to explore the protective effects of the adenosine monophosphate-activated protein kinase (AMPK)/mTOR signaling pathway on Cx43 expre...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.934488

    authors: Chen Y,Qiao X,Zhang L,Li X,Liu Q

    更新日期:2020-11-16 00:00:00

  • Vagal-immune interactions involved in cholinergic anti-inflammatory pathway.

    abstract::Inflammation and other immune responses are involved in the variety of diseases and disorders. The acute response to endotoxemia includes activation of innate immune mechanisms as well as changes in autonomic nervous activity. The autonomic nervous system and the inflammatory response are intimately linked and sympath...

    journal_title:Physiological research

    pub_type: 杂志文章,评审

    doi:10.33549/physiolres.933671

    authors: Zila I,Mokra D,Kopincova J,Kolomaznik M,Javorka M,Calkovska A

    更新日期:2017-09-22 00:00:00

  • Is severe pulmonary hypertension a contraindication for orthotopic heart transplantation? Not any more.

    abstract::Pulmonary hypertension (PH) unresponsive to pharmacological intervention is considered a contraindication for orthotopic heart transplantation (OHTX) due to risk of postoperative right-heart failure. In this prospective study, we describe our experience with a treatment strategy of improving severe PH in heart transpl...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932158

    authors: Kettner J,Dorazilová Z,Netuka I,Malý J,Al-Hiti H,Melenovský V,Skalský I,Říha H,Málek I,Kautzner J,Pirk J

    更新日期:2011-01-01 00:00:00

  • A model of stochastic activity of neurone in some types of Gaussian input processes.

    abstract::A new approach to computer modelling of neuronal stochastic activity is described. The output dynamic activity which depends on the types and the number of input synapses, weights of the synaptic efficacy, the absolute refractory phase duration and threshold level is evaluated on this model in some types of Gaussian i...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Novák V,Schmidt J

    更新日期:1996-01-01 00:00:00

  • Recombinant inbred strains in hypertension research.

    abstract::It was recognized that recombinant inbred strains are a very powerful system for the study of the genetics of hypertension, linkage analysis and gene mapping. Such set of recombinant inbred strains has been developed in the cooperation of Prof V. Kren and Dr. M. Pravenec in Prague. These recombinant inbred strains wer...

    journal_title:Physiological research

    pub_type: 社论

    doi:

    authors: Kunes J,Zicha J

    更新日期:1993-01-01 00:00:00

  • Effects of aging on activities of mitochondrial electron transport chain complexes and oxidative damage in rat heart.

    abstract::Mitochondrial dysfunction and accumulation of oxidative damage have been implicated to be the major factors of aging. However, data on age-related changes in activities of mitochondrial electron transport chain (ETC) complexes remain controversial and molecular mechanisms responsible for ETC dysfunction are still larg...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.932019

    authors: Tatarková Z,Kuka S,Račay P,Lehotský J,Dobrota D,Mištuna D,Kaplán P

    更新日期:2011-01-01 00:00:00

  • Systemic administration of miRNA mimics by liposomal delivery system in animal model of colorectal carcinoma.

    abstract::MiRNAs are important regulators of gene expression and changes in their levels are linked with various pathological states, including solid tumors. MiR-215 has been identified as a tumor suppressor in colorectal cancer (CRC). Following our previous in vitro and in vivo experiments, the aim of this project was to study...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:10.33549/physiolres.933546

    authors: Merhautová J,Vychytilová-Faltejsková P,Demlová R,Slabý O

    更新日期:2016-12-21 00:00:00

  • Local vasodilatation with metacholine, but not with nitroprusside, increases forearm glucose uptake.

    abstract::Insulin is known to increase blood flow in parallel to glucose uptake in skeletal muscle. However, it is not known if an increase in blood flow by itself is associated with an increase in glucose uptake in the absence of hyperinsulinemia. To investigate further this matter, the effect of increased blood flow on forear...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Sarabi M,Lind L,Millgard J,Hänni A,Hägg A,Berne C,Lithell H

    更新日期:1999-01-01 00:00:00

  • Noradrenaline reduces cardiovascular effects of the combined dipyridamole and AMP administration but preserves radioprotective effects of these drugs on hematopoiesis in mice.

    abstract::Recent results of the authors have demonstrated that the elevation of extracellular adenosine induced by the combined administration of dipyridamole, a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), a soluble adenosine prodrug, mediates radioprotective effects in mice. Furthermore...

    journal_title:Physiological research

    pub_type: 杂志文章

    doi:

    authors: Pospísil M,Hofer M,Vacek A,Netíková J,Pipalová I,Viklická S

    更新日期:1993-01-01 00:00:00