Abstract：
:Spontaneous activity of cortical neurons exhibits alternative fluctuations of membrane potential consisting of phased depolarization called "up-state" and persistent hyperpolarization called "down-state" during slow wave sleep and anesthesia. Here, we examined the effects of sound stimuli (noise bursts) on neuronal activity by intracellular recording in vivo from the rat auditory cortex (AC). Noise bursts increased the average time in the up-state by 0.81+/-0.65 s (range, 0.27-1.74 s) related to a 10 s recording duration. The rise times of the spontaneous up-events averaged 69.41+/-18.04 ms (range, 40.10-119.21 ms), while those of the sound-evoked up-events were significantly shorter (p<0.001) averaging only 22.54+/-8.81 ms (range, 9.31-45.74 ms). Sound stimulation did not influence ongoing spontaneous up-events. Our data suggest that a sound stimulus does not interfere with ongoing spontaneous neuronal activity in auditory cortex but can evoke new depolarizations in addition to the spontaneous ones.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Zhang Y,Han L,Xiao X,Hu B,Ruan H,Xiong Ydoi
10.33549/physiolres.932086subject
Has Abstractpub_date
2011-01-01 00:00:00pages
687-93issue
4eissn
0862-8408issn
1802-9973pii
932086journal_volume
60pub_type
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