Abstract：
:Contractility of the myocardium is determined by the interaction of contractile (actin and myosin) and regulatory (troponin and tropomyosin) proteins in the presence of calcium ions and chemical energy. The formation of the actomyosin complex is affected by the modulatory (C-, F-, M-proteins, actinins) and interstitial proteins (different types of collagens, glycoproteins, glycosaminoglycans, elastins). Cardiac hypoxia is accompanied by qualitative and quantitative changes in both collagenous (change in the proportion of different extracellular matrix proteins) and non-collagenous proteins (formation of different isomyosins and isoforms of actins or regulatory proteins). This remodelling of cardiac musculature influences significantly the process of contraction and relaxation in the hypoxic myocardium.
journal_name
Physiol Resjournal_title
Physiological researchauthors
Pelouch Vsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
53-60issue
1eissn
0862-8408issn
1802-9973journal_volume
44pub_type
杂志文章,评审abstract：:We investigated the effects of telmisartan, the blocker of angiotensin II receptor 1, on the regulation of systolic blood pressure (SBP) and oxidative stress through endothelial nitric oxide (NO) release in spontaneously hypertensive rats (SHRs). SHRs randomly received placebo, oral feeding of telmisartan (5 mg/kg or ...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932433
更新日期：2013-01-01 00:00:00
abstract：:Salivary cortisol reflects the free fraction of serum cortisol. Monitoring salivary cortisol may be a promising alternative method for assessing serum cortisol in some clinical situations. We aimed to compare the reliability of salivary vs. serum cortisol during ACTH test. 84 subjects (mean age 63.2; 24-89 years; n=66...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932611
更新日期：2014-01-01 00:00:00
abstract：:Impressive advances in molecular genetic techniques allow to analyze the effects of natural selection on the development of human genome. For example, the trend towards blonde hair and blue eyes was documented. The approach to analyze possible effects of natural selection on the evolution of recent phenotypes with hig...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933885
更新日期：2018-05-04 00:00:00
abstract：:Intrauterine and perinatal life are critical periods for programming of cardiometabolic diseases. However, their relative role remains controversial. We aimed to assess, at weaning, sex-dependent alterations induced by fetal or postnatal nutritional interventions on key organs for metabolic and cardiovascular control....
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932811
更新日期：2015-01-01 00:00:00
abstract：:For better understanding of pathophysiological processes leading to increased retention of sodium as a consequence of hyperlipidemia, the properties of renal Na,K-ATPase, a key enzyme involved in maintaining sodium homeostasis in the organism, were studied. Enzyme kinetics of renal Na,K-ATPase were used for characteri...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932153
更新日期：2011-01-01 00:00:00
abstract：:Circadian oscillations in biological variables in mammals are controlled by a central pacemaker in the suprachiasmatic nuclei (SCN) of the hypothalamus which coordinates circadian oscillators in peripheral tissues. The molecular clockwork responsible for this rhythmicity consists of several clock genes and their corre...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:We studied the response of several parameters related to oxidative stress in the liver of aging rats. Male Wistar rats aged 1.5, 3, 18 and 24 months were used. Livers showed an increase in superoxide anion (O(2)(-)) concentration at 1.5 and 18 months of age compared to the 3-month-old group; a decrease in superoxide d...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.931768
更新日期：2010-01-01 00:00:00
abstract：:Plant-based n-3 polyunsaturated fatty acids (PUFA) possess a prospective antiatherogenic potential. Currant oil from Ribes nigrum L. is one of the few plant oils containing PUFAn-3 (15.3 mol%) in addition to PUFAn-6 (60.5 mol%). This study was aimed at comparing the effects of currant oil with those of lard fat, rich ...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Atherogenesis involves the migration of leukocytes into vascular subendothelial space, a process mediated by endothelial and leukocyte cell adhesion molecules. Endothelial molecules are assessed indirectly via serum levels, but leukocyte molecules can be assessed directly. We have therefore hypothesized that leukocyte...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:The purpose of this study was to investigate plasma concentrations of cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) during and after real and simulated space flight. Venous blood was obtained 3 min after the beginning and 2 min after the lower body negative pressure maneuver in two cosmona...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Hemodynamics in the distal end-to-side anastomosis is related to early development of intimal hyperplasia and bypass failure. In this study we investigated the effect of diameter ratios between the target artery and the bypass at three different angles of the connection. The pulsatile flow field was visualized using p...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933297
更新日期：2016-12-13 00:00:00
abstract：:Familial hypercholesterolemia (FH) is most frequently caused by LDLR or APOB mutations. Therefore, the aim of our study was to examine the genetic background of Slovak patients suspected of FH. Patients with clinical suspicion of FH (235 unrelated probands and 124 family relatives) were recruited throughout Slovakia d...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933348
更新日期：2017-03-31 00:00:00
abstract：:Mitochondrial dysfunction and accumulation of oxidative damage have been implicated to be the major factors of aging. However, data on age-related changes in activities of mitochondrial electron transport chain (ETC) complexes remain controversial and molecular mechanisms responsible for ETC dysfunction are still larg...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932019
更新日期：2011-01-01 00:00:00
abstract：:Progressive compromise of antioxidant defenses and free radical-mediated lipid peroxidation, which is one of the major mechanisms of secondary traumatic brain injury (TBI), has also been reported in pediatric head trauma. In the present study, we aimed to demonstrate the effect of melatonin, which is a potent free rad...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Anthropogenic environmental pollutants affect many physiological, biochemical, and endocrine actions as reproduction, metabolism, immunity, behavior and as such can interfere with any aspect of hormone action. Microbiota and their genes, microbiome, a large body of microorganisms, first of all bacteria and co-existing...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934513
更新日期：2020-09-30 00:00:00
abstract：:To evaluate the role of chloride in the pathogenesis of salt-dependent deoxycorticosterone (DOC) hypertension, we studied young Wistar rats chronically loaded with sodium bicarbonate (NaHCO(3)) or sodium chloride (NaCl) which were administered either in the diet or in the drinking fluid. Selective sodium loading (with...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Adiponectin is an adipokine increasing glucose and fatty acid metabolism and improving insulin sensitivity. The aim of this study was to investigate the role of adiponectin in the regulation of adipocyte lipolysis. Human adipocytes isolated from biopsies obtained during surgical operations from 16 non-obese and 17 obe...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.931863
更新日期：2011-01-01 00:00:00
abstract：:In the mammalian neocortex, the calcium-binding protein calretinin is expressed in a subset of cortical interneurons. In the recent years, research on interneurons is one of the most rapidly growing fields in neuroscience. This review summarizes the actual knowledge of the functions of calretinin in neuronal homeostas...
journal_title：Physiological research
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:Hyperbaric oxygen (HBO) therapy, i.e. breathing pure oxygen under increased environmental pressures serves as a treatment for diverse medical conditions. However, elevated oxygen concentration can be detrimental to central nervous system or lungs. Our study aimed to evaluate the effects of repeated exposure to HBO on ...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934046
更新日期：2018-12-31 00:00:00
abstract：:T-2 toxin and its metabolite HT-2 toxin are one of the most toxic mycotoxins of type A-trichothecenes, which are produced mainly by Fusarium species. Therefore, study of Fusarium toxins T-2 toxin and HT-2 toxin is an essential issue because they could also play role in failures of reproductive functions as well as end...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933610
更新日期：2017-09-22 00:00:00
abstract：:The activity of antioxidant enzymes, copper-zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD) and catalase (CAT), as well as that of the mitochondrial FAD-dependent alpha-glycerophosphate dehydrogenase (alpha-GPD) in the rat interscapular brown adipose tissue (IBAT) were studied after the tre...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in t...
journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.933329
更新日期：2017-03-31 00:00:00
abstract：:Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.933745
更新日期：2018-07-17 00:00:00
abstract：:Cardiovascular disease, while rare in women of reproductive age, is the main cause of mortality in menopause. The purpose of our study was to determine the association of natural menopause with cardiovascular risk factors, including their clustering into metabolic syndrome (MS). A random 5 % representative population ...
journal_title：Physiological research
pub_type： 杂志文章,随机对照试验
doi：10.33549/physiolres.932313
更新日期：2012-01-01 00:00:00
abstract：:Recent results of the authors have demonstrated that the elevation of extracellular adenosine induced by the combined administration of dipyridamole, a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), a soluble adenosine prodrug, mediates radioprotective effects in mice. Furthermore...
journal_title：Physiological research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Methamphetamine is one of the most abused hard drugs in the Czech Republic. Its popularity is high not only in Eastern Bloc of Europe but is growing in other countries around the world, including the United States. In addition, methamphetamine abuse increases in drug addicts during pregnancy. Although research into th...
journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.934360
更新日期：2019-12-20 00:00:00
abstract：:Gain-of-function (GOF) mutations in ion channels are rare events, which lead to increased agonist sensitivity or altered gating properties, and may render the channel constitutively active. Uncovering and following characterization of such mutants contribute substantially to the understanding of the molecular basis of...
journal_title：Physiological research
pub_type： 杂志文章,评审
doi：10.33549/physiolres.932658
更新日期：2014-01-01 00:00:00
abstract：:It is believed that omentin is secreted by stromal cells of adipose tissue and modulates insulin sensitivity. Data from a few studies have shown lower serum omentin in obese children and higher in anorexia nervosa. However, to date, there is lack of research on serum omentin concentrations in adolescent patients in a ...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932841
更新日期：2015-01-01 00:00:00
abstract：:Monoaminergic neurotransmitter 5-hydroxytryptamine (5-HT), also known as serotonin, plays important roles in modulating the function of the olfactory system. However, thus far, the knowledge about 5-HT and its receptors in olfactory receptor neurons (ORNs) and their physiological role have not been fully characterized...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.932413
更新日期：2013-01-01 00:00:00
abstract：:The main role of research in medicine is to provide relevant knowledge which, after successful translation to clinical practice, improves the quality of healthcare. The sex bias which is still present in the majority of research disciplines prefers male subjects despite legislation changes in the US grant agencies and...
journal_title：Physiological research
pub_type： 杂志文章
doi：10.33549/physiolres.934593
更新日期：2020-12-31 00:00:00
