Distinct response of fat and gastrointestinal tissue to glucose in gestational diabetes mellitus and polycystic ovary syndrome.

abstract：:Leptin and adiponectin, two adipocytokines, may work together in regulating energy homeostasis and insulin action. Leptin gene expression has been investigated in term placental tissue complicated by gestational diabetes mellitus (GDM), but never in conjunction with all isoforms of the leptin receptor (LEPR A-D), or w...

journal_title：Physiological research

authors： Meller M,Qiu C,Vadachkoria S,Abetew DF,Luthy DA,Williams MA

更新日期：2006-01-01 00:00:00

abstract：:The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear superfamily of ligand-activated transcription factors. PPARgamma acts as a nutrient sensor that regulates several homeostatic functions. Its disruption can lead to vascular pathologies, disorders of fatty acid/lipid metabolism and insulin res...

journal_title：Physiological research

authors： Kvandová M,Majzúnová M,Dovinová I

更新日期：2016-10-24 00:00:00

abstract：:The present review brings the survey of the most frequently used behavioural tests in experimental models of Parkinson's disease (PD). Although there is no spontaneous occurrence of parkinsonism in animals, several experimental animal models of PD have been developed to achieve the same clinical features in animals. T...

journal_title：Physiological research

authors： Mokrý J

更新日期：1995-01-01 00:00:00

abstract：:Primary aldosteronism (PA) is the most common cause of endocrine hypertension with a high frequency of cardiovascular complications. The unfavorable cardiometabolic profile may be due to aldosterone-mediated activation of inflammatory cells, circulatory cytokines and activation of collagen synthesis in the vessel wall...

journal_title：Physiological research

authors： Šomlóová Z,Petrák O,Rosa J,Štrauch B,Indra T,Zelinka T,Haluzík M,Zikán V,Holaj R,Widimský J Jr

更新日期：2016-06-20 00:00:00

abstract：:Pregnant rats were exposed to intermittent hypobaric hypoxia (at a simulated altitude of 7000 m or 5000 m) and the excitability of cortical neurons of their pups was tested. Stimulation of the sensorimotor cortex of rats prenatally exposed to hypoxia shortened the duration of cortical afterdischarges in 12-day-old rat...

journal_title：Physiological research

authors： Maresová D,Valkounová I,Jandová K,Bortelová J,Trojan S

更新日期：2001-01-01 00:00:00

abstract：:K(+)-p-nitrophenylphosphatase (K(+)pNPPase) is the enzyme, which is considered to be involved in K(+)-dependent hydrolysis of the phosphoenzyme in the reaction cycle of Na(+), K(+)ATPase. The aim of our present study was to characterize some features of K(+)pNPPase in homogenates of the rat brain and liver. We determi...

journal_title：Physiological research

authors： Durfinová M,Brechtlová M,Líska B,Barosková Z

更新日期：2009-01-01 00:00:00

abstract：:We studied the psychophysiology of soluble intercellular adhesion molecule-1 (sICAM-1) in 25 apparently healthy middle-aged men who underwent an acute psychosocial stressor three times with one week apart. Measures of the biological stress response were obtained at week one and three. The magnitude of the sICAM-1 stre...

journal_title：Physiological research

authors： von Känel R,Preckel D,Kudielka BM,Fischer JE

更新日期：2007-01-01 00:00:00

abstract：:Mutations in troponin T (TNNT2) gene represent the important part of currently identified disease-causing mutations in hypertrophic (HCM) and dilated (DCM) cardiomyopathy. The aim of this study was to analyze TNNT2 gene exons in patients with HCM and DCM diagnosis to improve diagnostic and genetic consultancy in affec...

journal_title：Physiological research

authors： Jáchymová M,Muravská A,Paleček T,Kuchynka P,Řeháková H,Magage S,Král A,Zima T,Horký K,Linhart A

更新日期：2012-01-01 00:00:00

abstract：:Cardiovascular disease, while rare in women of reproductive age, is the main cause of mortality in menopause. The purpose of our study was to determine the association of natural menopause with cardiovascular risk factors, including their clustering into metabolic syndrome (MS). A random 5 % representative population ...

journal_title：Physiological research

authors： Lejsková M,Alušík S,Valenta Z,Adámková S,Piťha J

更新日期：2012-01-01 00:00:00

abstract：:Parenteral nutrition-associated liver disease (PNALD) is a severe complication in patients completely dependent on parenteral nutrition (PN). The gold diagnostic standard, liver biopsy, is associated with significant health risk and therefore its use is limited. MicroRNAs (miRNAs) are small non-coding regulatory RNA m...

journal_title：Physiological research

authors： Cahová M,Daňková H,Heczková M,Brátová M,Ďásková N,Baštová H,Gojda J,Wohl P

更新日期：2019-08-29 00:00:00

abstract：:The aim of this study was to assess the molecular basis of renal Na,K-ATPase disturbances in response to NO-deficient hypertension induced in rats by NO-synthase inhibition with 40 mg/kg/day N(G)-nitro-L-arginine methyl ester (L-NAME) for four weeks. After 4-week administration of L-NAME, the systolic blood pressure (...

journal_title：Physiological research

authors： Vrbjar N,Javorková V,Pechánová O

更新日期：2002-01-01 00:00:00

abstract：:It is believed that omentin is secreted by stromal cells of adipose tissue and modulates insulin sensitivity. Data from a few studies have shown lower serum omentin in obese children and higher in anorexia nervosa. However, to date, there is lack of research on serum omentin concentrations in adolescent patients in a ...

journal_title：Physiological research

authors： Oświęcimska J,Suwała A,Świętochowska E,Ostrowska Z,Gorczyca P,Ziora-Jakutowicz K,Machura E,Szczepańska M,Kukla M,Stojewska M,Ziora D,Ziora K

更新日期：2015-01-01 00:00:00

abstract：:In the mammalian neocortex, the calcium-binding protein calretinin is expressed in a subset of cortical interneurons. In the recent years, research on interneurons is one of the most rapidly growing fields in neuroscience. This review summarizes the actual knowledge of the functions of calretinin in neuronal homeostas...

journal_title：Physiological research

authors： Barinka F,Druga R

更新日期：2010-01-01 00:00:00

abstract：:Prazosin, an alpha(1)-adrenoceptor antagonist, is well known for its depressant effect on motivation and motor activity, while it has no effect on retention of spatial behavior in several tasks, e.g. in the Morris water maze and radial arm maze. The role of alpha(1)-adrenoceptors in operant tasks with stimulus-control...

journal_title：Physiological research

authors： Levčík D,Stuchlík A,Klement D

更新日期：2013-01-01 00:00:00

abstract：:Because greater Akt substrate of 160 kDa (AS160) phosphorylation has been reported in insulin-stimulated skeletal muscles without improved Akt activation several hours post-exercise, we hypothesized that prior exercise would result in attenuated AS160 dephosphorylation in insulin-stimulated rat skeletal muscle. Epitro...

journal_title：Physiological research

authors： Arias EB,Wang H,Cartee GD

更新日期：2018-03-16 00:00:00

abstract：:Senile dementia of Alzheimer's type (AD) is commonly characterized as a neurodegenerative disorder, which exhibits gradual changes of consciousness, loss of memory, perception and orientation as well as loss of personality and intellect. AD prevalence increases dramatically with age and is the fourth cause of death in...

journal_title：Physiological research

authors： Rípová D,Strunecká A

更新日期：2001-01-01 00:00:00

abstract：:Clusterin is a heterodimeric glycoprotein with wide range of functions. To further explore its possible regulatory role in energy homeostasis and in adipose tissue, we measured plasma clusterin and its mRNA expression in subcutaneous adipose tissue (SCAT) of 15 healthy lean women, 15 obese women (OB) and 15 obese wome...

journal_title：Physiological research

authors： Kloučková J,Lacinová Z,Kaválková P,Trachta P,Kasalický M,Haluzíková D,Mráz M,Haluzík M

更新日期：2016-07-18 00:00:00

abstract：:Argyrophil nucleolar organizer regions (AgNORs) were morphometrically evaluated in rat anterior pituitaries of control and oestrogenized rats using an automatized (LUCIA M--Laboratory Universal Computer Image Analysis Micro) and a non-automatized approaches to investigate not only the sensitivity and effectiveness of ...

journal_title：Physiological research

authors： Dusková J,Povýsil C,Schreiber V

更新日期：1995-01-01 00:00:00

abstract：:Silymarin and silybin are widely used for their hepatoprotective properties. Our previous studies confirm positive effect of silymarin on lipoprotein profile and lipid homeostasis. Advanced drug forms may improve the bioavailability of these compounds. In this study, we investigate the effects of silybin in different ...

journal_title：Physiological research

authors： Poruba M,Matušková Z,Kazdová L,Oliyarnyk O,Malínská H,Tozzi di Angelo I,Večeřa R

更新日期：2015-01-01 00:00:00

abstract：:The overproduction of the free radical nitric oxide (NO) by activated immunocompetent cells with subsequent development of local oxidative stress is supposed to be one of the possible pathophysiological mechanisms of beta-cell damage during streptozotocin-induced diabetes. The blockade of increased NO production by si...

journal_title：Physiological research

authors： Haluzík M,Nedvídková J

更新日期：2000-01-01 00:00:00

abstract：:In this experiment we studied the effect of different pedalling rates during cycling at a constant power output (PO) 132+/-31 W (mean+/-S.D.), corresponding to 50% VO2 max, on the oxygen uptake and the magnitude of the slow component of VO2 kinetics in humans. The PO corresponded to 50% of VO2 max, established during ...

journal_title：Physiological research

authors： Zoladz JA,Duda K,Majerczak J

更新日期：1998-01-01 00:00:00

abstract：:Ubiquitination is a versatile tool used by all eukaryotic organisms for controlling the stability, function, and intracellular localization of a multitude of proteins. I will attempt to bring together our recent data on the down-regulation of two yeast model proteins, the galactose transporter Gal2 and fructose-1,6-bi...

journal_title：Physiological research

authors： Horák J

更新日期：2004-01-01 00:00:00

abstract：:This study aimed to examine relationships between DHEA(S), anthropometric parameters, oral glucose tolerance test derived data and lipid spectra in a Czech non-diabetic population. 380 healthy volunteers both with and without a family history of diabetes type 2 (DM2) were enrolled into the study (women: n=235, age 28....

journal_title：Physiological research

authors： Bendlová B,Vrbíková J,Hill M,Vanková M,Lukásová P,Vcelák J,Vejrazková D,Dvoráková K,Hampl R,Vondra K,Stárka L

更新日期：2008-01-01 00:00:00

abstract：:The mood and behavior of individuals result from an orchestra of many factors. Among them steroids play an important role; however, only several common hormones have been investigated in this respect. It has been demonstrated that some steroid metabolites long considered merely the products of steroid hormone metaboli...

journal_title：Physiological research

authors： Dušková M,Hill M,Bičíková M,Šrámková M,Řípová D,Mohr P,Stárka L

更新日期：2015-01-01 00:00:00

abstract：:Endothelin alters central sympathetic responses, but the resultant effects on arrhythmogenesis are unknown. We examined ventricular tachyarrhythmias after endothelin receptor-A blockade in the brain of Wistar rats with acute myocardial infarction. For this aim, BQ-123 (n=6) or phosphate-buffered saline (n=6) were inje...

journal_title：Physiological research

authors： Lekkas P,Georgiou ES,Kontonika M,Mouchtouri ET,Mourouzis I,Pantos C,Kolettis TM

更新日期：2019-10-25 00:00:00

abstract：:Young intact (18 days of age) and adult ovariectomized (OV-X, ovariectomized between 21 to 24 days of age) C3H/Di mice were used to measure the estrogenicity on the basis of the growth response of mammary epithelial structures and weight of the uterus. The percentage area of the mammary fat pad occupied by mammary epi...

journal_title：Physiological research

authors： Skarda J

更新日期：2002-01-01 00:00:00

abstract：:Nephrotoxicity of cisplatin (CP) involves renal oxidative stress and inflammation, and sesamin (a major liganin in many plants) has strong antioxidant and antiinflammatory actions. Therefore, we investigated here the possible mitigative action of sesamin on CP nephrotoxicity in rats. Sesamin was given orally (5 mg/kg/...

journal_title：Physiological research

authors： Ali BH,Al Salam S,Al Suleimani Y,Al Za'abi M,Ashique M,Manoj P,Sudhadevi M,Al Tobi M,Nemmar A

更新日期：2020-02-19 00:00:00

abstract：:To predict more precisely the effect of stobadine, a pyridoindole antioxidant agent, in the whole organism, we studied its effect on opsonized zymosan-stimulated free radical generation in whole blood, on superoxide generation in the mixture of PMNL : platelets (1:50), as well as on superoxide generation and myelopero...

journal_title：Physiological research

authors： Pecivová J,Macicková T,Cíz M,Nosál R,Loje A

更新日期：2004-01-01 00:00:00

abstract：:It was recognized that recombinant inbred strains are a very powerful system for the study of the genetics of hypertension, linkage analysis and gene mapping. Such set of recombinant inbred strains has been developed in the cooperation of Prof V. Kren and Dr. M. Pravenec in Prague. These recombinant inbred strains wer...

journal_title：Physiological research

authors： Kunes J,Zicha J

更新日期：1993-01-01 00:00:00

abstract：:Inhibition of receptor-interacting serine/threonine-protein kinase 1 (RIP1) by necrostatin-1 (Nec-1) alleviates cardiac injury due to prevention of necroptotic cell death. Its inactive analogue necrostatin-1i (Nec-1i), lacking RIP1 activity, serves as a suitable control. It is unknown if these agents influence the hea...

journal_title：Physiological research

authors： Szobi A,Rajtik T,Adameova A

更新日期：2016-11-23 00:00:00