Experimental models and behavioural tests used in the study of Parkinson's disease.

abstract：:The aim of this study was to explore changes in plasma vascular endothelial growth factor (VEGF) in aged patients who undergone transcatheter aortic valve implantation or balloon angioplasty for the treatment of aortic stenosis. Plasma VEGF was measured in subjects with diabetes mellitus type 2 (DM) (n=21, age 79.2+/-...

journal_title：Physiological research

authors： Bláha V,Šťásek J,Bis J,Fortunato J,Andrýs C,Pavlík V,Polanský P,Brtko M,Sobotka L

更新日期：2014-01-01 00:00:00

abstract：:The goal of this study is to evaluate if promotion of angiogenesis by systemic treatment with an antagomir against miR-92a, a well established inhibitor of angiogenesis, will maximize the benefits of exercise on bone. Ten week old female C57BL6/J mice were subjected to two weeks of external load by four point bending....

journal_title：Physiological research

authors： Sengul A,Santisuk R,Xing W,Kesavan C

更新日期：2013-01-01 00:00:00

abstract：:Pregnant rats were exposed to intermittent hypobaric hypoxia (at a simulated altitude of 7000 m or 5000 m) and the excitability of cortical neurons of their pups was tested. Stimulation of the sensorimotor cortex of rats prenatally exposed to hypoxia shortened the duration of cortical afterdischarges in 12-day-old rat...

journal_title：Physiological research

authors： Maresová D,Valkounová I,Jandová K,Bortelová J,Trojan S

更新日期：2001-01-01 00:00:00

abstract：:Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their level...

journal_title：Physiological research

authors： Cibičková Ľ,Langová K,Vaverková H,Kubíčková V,Karásek D

更新日期：2017-07-18 00:00:00

abstract：:In this study we analyzed the effects of melatonin (Mel, 1 mg/kg ip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH)...

journal_title：Physiological research

authors： Tasset I,Medina FJ,Peña J,Jimena I,Del Carmen Muñoz M,Salcedo M,Ruiz C,Feijóo M,Montilla P,Túnez I

更新日期：2010-01-01 00:00:00

abstract：:We measured plasma concentrations, adipose tissue and placental mRNA expression of hepatokines fetuin A, fetuin B and fibroblast growth factor 21 (FGF21) in 12 healthy pregnant women (P group), 12 pregnant women with gestational diabetes (GDM) and 10 healthy non-pregnant women (N group) to explore their potential role...

journal_title：Physiological research

authors： Šimják P,Cinkajzlová A,Anderlová K,Kloučková J,Kratochvílová H,Lacinová Z,Kaválková P,Krejčí H,Mráz M,Pařízek A,Kršek M,Haluzík M

更新日期：2018-11-28 00:00:00

abstract：:This study was undertaken to investigate the effects of lower body positive pressure (LBPP) on cardiovascular responses during a 15-min walking trial in young (22.1+/-0.4 years) and elderly women (67.8+/-1.1 years). The application of 20 mm Hg LBPP reduced ground reaction forces by 31.2+/-0.5 kgw in both groups. We hy...

journal_title：Physiological research

authors： Sota T,Matsuo S,Uchida Y,Hagino H,Kawai Y

更新日期：2013-01-01 00:00:00

abstract：:Stomach lesions induced by indomethacin (20 mg.kg-1 i.p.) and ethanol (1 ml 95% intragastrically) were studied after a 24 hour fast in rats which had undergone sialoadenectomy. The size of the lesions was correlated with gastric HCl secretion, with gastric vascular permeability (determined from the Evans blue concentr...

journal_title：Physiological research

authors： Kohút A,Maheĺová O,Mojzís J,Mirossay L

更新日期：1992-01-01 00:00:00

abstract：:Rat skeletal muscle myofibrils were incubated in the presence of D-glucose, D-fructose, D-galactose, D-ribose, D-tagatose, D-arabinose, D-xylose, D-mannose, L-sorbose, L-rhamnose or DL-glyceraldehyde and myofibrillar ATPase activity as well as the extent of glycation was measured. The attachment of sugars to proteins ...

journal_title：Physiological research

authors： Syrový I

更新日期：1994-01-01 00:00:00

abstract：:To compare circulating pigment epithelium derived factor (PEDF) levels in type 2 diabetes patients (T2D) with and without metabolic syndrome (MetS+/-) to healthy controls and assess PEDF association with plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF) as markers of endothelial dysfunction. Fi...

journal_title：Physiological research

authors： Karasek D,Spurna J,Kubickova V,Krystynik O,Cibickova L,Schovanek J,Goldmannova D

更新日期：2019-06-30 00:00:00

abstract：:The aim of this study was to obtain a detailed analysis of the relationship between the finger arterial compliance C [ml/mm Hg] and the arterial transmural pressure P(t) [mm Hg]. We constructed a dynamic plethysmograph enabling us to set up a constant pressure P(css) [mm Hg] and a superimposed fast pressure vibration ...

journal_title：Physiological research

authors： Moudr J,Svačinová J,Závodná E,Honzíková N

更新日期：2014-01-01 00:00:00

abstract：:Argyrophil nucleolar organizer regions (AgNORs) were morphometrically evaluated in rat anterior pituitaries of control and oestrogenized rats using an automatized (LUCIA M--Laboratory Universal Computer Image Analysis Micro) and a non-automatized approaches to investigate not only the sensitivity and effectiveness of ...

journal_title：Physiological research

authors： Dusková J,Povýsil C,Schreiber V

更新日期：1995-01-01 00:00:00

abstract：:Endothelin alters central sympathetic responses, but the resultant effects on arrhythmogenesis are unknown. We examined ventricular tachyarrhythmias after endothelin receptor-A blockade in the brain of Wistar rats with acute myocardial infarction. For this aim, BQ-123 (n=6) or phosphate-buffered saline (n=6) were inje...

journal_title：Physiological research

authors： Lekkas P,Georgiou ES,Kontonika M,Mouchtouri ET,Mourouzis I,Pantos C,Kolettis TM

更新日期：2019-10-25 00:00:00

abstract：:To estimate the significance of insulin in the regulation of preimplantation embryo growth, female mice received a single subdiabetogenic dose of streptozocin (65 mg/kg intraperitoneally) 8-11 days or 14-17 days before fertilization. Mean glycaemia levels and the number of embryos per mouse did not differ significantl...

journal_title：Physiological research

authors： Veselá J,Rehák P,Baran V,Koppel J

更新日期：1993-01-01 00:00:00

abstract：:The purpose of this study was to determine if there is flow-mediated vasodilation of the femoral artery in response to progressive increases in flow within a physiological range observed in the in vivo experiments. Femoral artery blood flow was determined in conscious rabbits (n = 5) using chronically implanted flowpr...

journal_title：Physiological research

authors： Clifford PS,Madden JA,Hamann JJ,Buckwalter JB,Valic Z

更新日期：2010-01-01 00:00:00

abstract：:Reduced physical activity and abundant energy intake are two most common factors leading to uncontrolled body weight gain. But these factors are not under entire internal consciousness control; they are also partially genetically determined and are affected by for example food marketing practices. In addition to these...

journal_title：Physiological research

authors： Hubácek JA

更新日期：2009-01-01 00:00:00

abstract：:The basis for most acute coronary events is either rupture or fissuring of unstable atherosclerotic plaques with subsequent thrombosis leading to coronary artery occlusion. The development of atherosclerotic plaques takes several decades, but the mechanical features determining its stability and the risk of rupture ca...

journal_title：Physiological research

authors： Stulc T,Ceska R

更新日期：2001-01-01 00:00:00

abstract：:It is believed that omentin is secreted by stromal cells of adipose tissue and modulates insulin sensitivity. Data from a few studies have shown lower serum omentin in obese children and higher in anorexia nervosa. However, to date, there is lack of research on serum omentin concentrations in adolescent patients in a ...

journal_title：Physiological research

authors： Oświęcimska J,Suwała A,Świętochowska E,Ostrowska Z,Gorczyca P,Ziora-Jakutowicz K,Machura E,Szczepańska M,Kukla M,Stojewska M,Ziora D,Ziora K

更新日期：2015-01-01 00:00:00

abstract：:Intrauterine and perinatal life are critical periods for programming of cardiometabolic diseases. However, their relative role remains controversial. We aimed to assess, at weaning, sex-dependent alterations induced by fetal or postnatal nutritional interventions on key organs for metabolic and cardiovascular control....

journal_title：Physiological research

authors： Munoz-Valverde D,Rodríguez-Rodríguez P,Gutierrez-Arzapalo PY,López de Pablo AL,Carmen González M,López-Giménez R,Somoza B,Arribas SM

更新日期：2015-01-01 00:00:00

abstract：:We report that decreased expression of miR-30c in tumor compared to adjacent tissue is sex-dependent in colorectal cancer (CRC) patients. High expression of miR-30c was associated with better survival in the whole cohort. When the cohort was split into male and female subcohorts, decreased miR-30c expression in tumor ...

journal_title：Physiological research

authors： Herichova I,Reis R,Hasakova K,Vician M

更新日期：2020-12-31 00:00:00

abstract：:Extensive osteolysis adjacent to orthopedic implants is often associated with wear particles of prosthetic material. The activation of the RANKL/RANK/OPG system is considered to be a likely cause of periprosthetic osteolysis leading to implant failure. The aim of this study was to examine the possible correlation betw...

journal_title：Physiological research

authors： Veigl D,Niederlová J,Krystůfková O

更新日期：2007-01-01 00:00:00

abstract：:It has been suggested that thiazolidinediones (TZDs) ameliorate insulin resistance in muscle tissue by suppressing muscle lipid storage and the activity of novel protein kinase C (nPKC) isoforms. To test this hypothesis, we analyzed long-term metabolic effects of pioglitazone and the activation of nPKC-epsilon and -th...

journal_title：Physiological research

authors： Marková I,Zídek V,Musilová A,Šimáková M,Mlejnek P,Kazdová L,Pravenec M

更新日期：2010-01-01 00:00:00

abstract：:In this study we investigated the effect of beta-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 microg of glucan by i.p. route, were assayed. In v...

journal_title：Physiological research

authors： Pelizon AC,Kaneno R,Soares AM,Meira DA,Sartori A

更新日期：2005-01-01 00:00:00

abstract：:Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining normal blood pressure, kidney function and water and electrolyte homeostasis. The renal microvasculature expresses a multitude of receptors mediating vasodilation and vasoconstriction, which can influence glomerular blood f...

journal_title：Physiological research

authors： Guan Z,Makled MN,Inscho EW

更新日期：2020-07-16 00:00:00

abstract：:Hindlimb unweighting (HU) leads to capillary regression in skeletal muscle. However, the molecular mechanism(s) remains to be elucidated. To gain insight into the regulation of this process, we investigated gene expression of hypoxia-inducible factor-1alpha (HIF-1alpha)vascular endothelial growth factor (VEGF), angiop...

journal_title：Physiological research

authors： Wagatsuma A

更新日期：2008-01-01 00:00:00

abstract：:Endometrial cancer is one of the most frequent gynecological malignancies present in more than 95 % of all uterine cancers. In spite of that, screening of such disease is not commonly performed in clinical practice due to enormous costs and relatively low sensitivity. Therefore, developing an effective screening test ...

journal_title：Physiological research

authors： Kacírová M,Bober P,Alexovič M,Tomková Z,Tkáčiková S,Talian I,Mederová L,Bérešová D,Tóth R,Andrašina I,Kožlejová Z,Kilík R,Divín R,Sabo J

更新日期：2019-12-30 00:00:00

abstract：:The mitochondrial DNA (mtDNA) amount in cells as the basis for mitochondrial energy generating system, which produces ATP, plays an important role in the fetal development and postnatal morbidity. Isolated human cord blood leukocytes (HCBL) contribute very little to the overall metabolic turnover, but they may serve a...

journal_title：Physiological research

authors： Pejznochová M,Tesarová M,Honzík T,Hansíková H,Magner M,Zeman J

更新日期：2008-01-01 00:00:00

abstract：:The aim of the present work was to investigate a new mechanism likely contributing to the toxic action of acetaminophen, especially to explore the possible inhibition of glutathione reductase through an acetaminophen-glutathione conjugate (APAP-SG). APAP-SG conjugate was synthesized by organic synthesis and purified b...

journal_title：Physiological research

authors： Rousar T,Pařík P,Kucera O,Bartos M,Červinková Z

更新日期：2010-01-01 00:00:00

abstract：:Aldosterone receptor antagonist, spironolactone, has been shown to prevent remodeling of the heart in several models of left ventricular hypertrophy. The aim of the present study was to determine whether the treatment with spironolactone can prevent hypertension, reduction of tissue nitric oxide synthase activity and ...

journal_title：Physiological research

authors： Simko F,Matúsková J,Lupták I,Pincíková T,Krajcírovicová K,Stvrtina S,Pomsár J,Pelouch V,Paulis L,Pechánová O

更新日期：2007-01-01 00:00:00

abstract：:Rhythmic daily changes in the Na,K-ATPase activity have been previously described for rat kidney cortex, showing two peaks: at 0900 h and 2100 h, and two valleys: at 1500 h and 0100 h -0300 h. The oscillations in Na,K-ATPase activity are produced by an inhibitor, which binds the enzyme and is present in the rat blood ...

journal_title：Physiological research

authors： Reyes A,Galindo MM,García L,Segura-Pena D,Caruso-Neves C,Eblen-Zajjur A,Proverbio T,Marín R,Proverbio F

更新日期：2009-01-01 00:00:00