The role of VEGF in the diabetic patients undergoing endovascular therapy of symptomatic aortic valve stenosis.

abstract：:Hepcidin, a recently discovered antimicrobial peptide synthesized in the liver, was identified to be the key mediator of iron metabolism and distribution. Despite our knowledge of hepcidin increased in recent years, there are only limited data on hepcidin regulation during systemic inflammatory response in human subje...

journal_title：Physiological research

authors： Maruna P,Vokurka M,Lindner J

更新日期：2011-01-01 00:00:00

abstract：:Exposure to hyperbaric oxygen leads to increased amount of reactive oxygen species (ROS) that are derived from various sources. After the discovery that ROS can function as signaling molecules, the idea of ROS being hazardous to biological tissues has been challenged. The aim of this study was to examine the changes i...

journal_title：Physiological research

authors： Gürdöl F,Cimşit M,Oner-Iyidoğan Y,Körpinar S,Yalçinkaya S,Koçak H

更新日期：2008-01-01 00:00:00

abstract：:The influence of chronic angiotensin AT1 receptor blockade by specific antibody on the development of genetic hypertension was studied in young spontaneously hypertensive rats (SHR). The immunization of 4-week-old SHR with a small part of the angiotensin AT1 receptor molecule attenuated the development of hypertension...

journal_title：Physiological research

authors： Zelezná B,Velek J,Veselský L,Zicha J,Dobesová Z,Kunes J

更新日期：1996-01-01 00:00:00

abstract：:Ferritin and increased iron stores first appeared on the list of cardiovascular risk factors more than 30 years ago and their causal role in the pathogenesis of atherosclerosis has been heavily discussed since the early 1990s. It seems that besides traditional factors such as hyperlipoproteinemia, hypertension, diabet...

journal_title：Physiological research

authors： Kraml P

更新日期：2017-04-05 00:00:00

abstract：:Progesterone and estradiol are the foremost steroid hormones in human pregnancy. However, the origin of maternal progesterone has still not been satisfactorily explained, despite the generally accepted opinion that maternal LDL-cholesterol is a single substrate for placental synthesis of maternal progesterone. The que...

journal_title：Physiological research

authors： Hill M,Pařízek A,Jirásek JE,Jirkovská M,Velíková M,Dušková M,Klímková M,Pasková A,Zizka Z,Germanová A,Koucký M,Kalousová M,Stárka L

更新日期：2010-01-01 00:00:00

abstract：:We sought to examine the association between maternal erythrocyte omega-3, omega-6 and trans fatty acids and risk of preeclampsia. We conducted a case-control study of 170 women with proteinuric, pregnancy-induced hypertension and 185 normotensive pregnant women who delivered at Harare Maternity Hospital, Harare, Zimb...

journal_title：Physiological research

authors： Mahomed K,Williams MA,King IB,Mudzamiri S,Woelk GB

更新日期：2007-01-01 00:00:00

abstract：:Through the analysis of the common apolipoprotein (apo) E gene polymorphism in large Caucasian population study with the PCR and subsequent restriction analysis, we have identified carriers of mutant allele Arg136-->Ser. Both of them (71-years-old female and her 43-years-old son) have normal lipid parameters. We sugge...

journal_title：Physiological research

authors： Hubácek JA,Adámková V,Skodová Z

更新日期：2005-01-01 00:00:00

abstract：:Mutations in troponin T (TNNT2) gene represent the important part of currently identified disease-causing mutations in hypertrophic (HCM) and dilated (DCM) cardiomyopathy. The aim of this study was to analyze TNNT2 gene exons in patients with HCM and DCM diagnosis to improve diagnostic and genetic consultancy in affec...

journal_title：Physiological research

authors： Jáchymová M,Muravská A,Paleček T,Kuchynka P,Řeháková H,Magage S,Král A,Zima T,Horký K,Linhart A

更新日期：2012-01-01 00:00:00

abstract：:Metabolic syndrome and one of its manifestations, essential hypertension, is an important cause of worldwide morbidity and mortality. Morbidity and mortality associated with hypertension are caused by organ complications. Previously we revealed a decrease of blood pressure and an amelioration of cardiac fibrosis in a ...

journal_title：Physiological research

authors： Mirchi LF,Chylíková B,Janků M,Šeda O,Liška F

更新日期：2019-10-25 00:00:00

abstract：:The present study evaluates the protective role of Quercetin (Quer), against immobilization stress- induced anxiety, depression and cognition alteration in mice using behavioral and biochemical parameters. 24 adult Albino mice were distributed into 2 groups vehicle (n=12; 1 ml/kg) and Quer injected (n=12; 20 mg/kg/ml)...

journal_title：Physiological research

authors： Samad N,Saleem A,Yasmin F,Shehzad MA

更新日期：2018-11-14 00:00:00

abstract：:The concept of vena contracta space reduction in tricuspid valve position was tested in an animal model. Feasibility of specific artificial obturator body (REMOT) fixed to the right ventricular apex and interacting with tricuspid valve leaflets was evaluated in three different animal studies. Catheter-based technique ...

journal_title：Physiological research

authors： Sochman J,Peregrin JH,Pavcnik D,Uchida BT,Timmermans HA,Sedmera D,Benada O,Kofronova O,Keller FS,Rosch J

更新日期：2014-01-01 00:00:00

abstract：:Experiments were carried out to determine whether there are separate drives from the selected neuronal networks of the brainstem affecting the discharge patterns of laryngeal and respiratory pump muscles during cough. Twenty-four non-decerebrate spontaneously breathing cats anesthetized with sodium pentobarbitone were...

journal_title：Physiological research

authors： Poliacek I,Stránsky A,Szereda-Przestaszewska M,Jakus J,Baráni H,Tomori Z,Halasová E

更新日期：2005-01-01 00:00:00

abstract：:Fibroblast growth factor-21 (FGF-21) has been recently characterized as a new adipokine. The aim of this study was to assess FGF-21 levels in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationship between FGF-21, disease activity and metabolic status. The levels of FGF-21 in seru...

journal_title：Physiological research

authors： Hulejová H,Andrés Cerezo L,Kuklová M,Pecha O,Vondráček T,Pavelka K,Vencovský J,Haluzík M,Senolt L

更新日期：2012-01-01 00:00:00

abstract：:The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in t...

journal_title：Physiological research

authors： Ziaaldini MM,Hosseini SR,Fathi M

更新日期：2017-03-31 00:00:00

abstract：:We studied the effect of thiazide-like diuretic--indapamide on fibrosis development in the left ventricle of young spontaneously hypertensive rats (SHR) and assessed the involvement of nitric oxide in this process. Six-week-old male SHR were treated with indapamide (1 mg/kg/day) for six weeks. Age-matched SHR were use...

journal_title：Physiological research

authors： Janega P,Kojsová S,Jendeková L,Babál P,Pechánová O

更新日期：2007-01-01 00:00:00

abstract：:We developed a novel behavioral task in which rats learn to recognize the configuration of objects in an animated scene displayed on a computer screen. The scene consisted of a moving bar and a stationary rectangle. Rats deprived of food were trained to press a lever for reward in a small chamber located in front of t...

journal_title：Physiological research

authors： Nekovárová T,Klement D

更新日期：2006-01-01 00:00:00

abstract：:We measured plasma concentrations, adipose tissue and placental mRNA expression of hepatokines fetuin A, fetuin B and fibroblast growth factor 21 (FGF21) in 12 healthy pregnant women (P group), 12 pregnant women with gestational diabetes (GDM) and 10 healthy non-pregnant women (N group) to explore their potential role...

journal_title：Physiological research

authors： Šimják P,Cinkajzlová A,Anderlová K,Kloučková J,Kratochvílová H,Lacinová Z,Kaválková P,Krejčí H,Mráz M,Pařízek A,Kršek M,Haluzík M

更新日期：2018-11-28 00:00:00

abstract：:The potential of novel scaffold containing sodium hyaluronate, type I collagen, and fibrin was investigated in the regeneration of osteochondral defects in miniature pigs. Both autologous chondrocyte-seeded scaffolds and non-seeded scaffolds were implanted into two defects located in the non-weight-bearing zone of the...

journal_title：Physiological research

authors： Filová E,Rampichová M,Handl M,Lytvynets A,Halouzka R,Usvald D,Hlucilová J,Procházka R,Dezortová M,Rolencová E,Kostáková E,Trc T,Stastný E,Kolácná L,Hájek M,Motlík J,Amler E

更新日期：2007-01-01 00:00:00

abstract：:The aim of the present study was to compare the oscillations of oxygenation in skeletal muscle between early and late phases in prolonged exercise. During prolonged exercise at 60 % of peak oxygen uptake (V(.)o(2)) for 60 min and at rest, oxygenated hemoglobin/myoglobin (Hb/MbO(2)) and total Hb/Mb (THb/Mb) were determ...

journal_title：Physiological research

authors： Yano T,Lian CS,Arimitsu T,Yamanaka R,Afroundeh R,Shirakawa K,Yunoki T

更新日期：2013-01-01 00:00:00

abstract：:Digitonin solubilizes mitochondrial membrane, breaks the integrity of the respiratory chain and releases two mobile redox-active components: coenzyme Q (CoQ) and cytochrome c (cyt c). In the present study we report the inhibition of glycerol-3-phosphate- and succinate-dependent oxygen consumption rates by digitonin tr...

journal_title：Physiological research

authors： Rauchová H,Vokurková M,Drahota Z

更新日期：2012-01-01 00:00:00

abstract：:Certain liver metabolic diseases point to the presence of disturbances in glycogen deposition. Epinephrine raises the cAMP level that activates protein kinase A leading to the activation of phosphorylase and glycogen breakdown. In the present report, we sought to investigate whether NO is produced during adrenoceptor ...

journal_title：Physiological research

authors： Hodis J,Kutinová-Canová N,Potmesil P,Kameníková L,Kmonícková E,Zídek Z,Farghali H

更新日期：2007-01-01 00:00:00

abstract：:The purpose of this study was to determine if there is flow-mediated vasodilation of the femoral artery in response to progressive increases in flow within a physiological range observed in the in vivo experiments. Femoral artery blood flow was determined in conscious rabbits (n = 5) using chronically implanted flowpr...

journal_title：Physiological research

authors： Clifford PS,Madden JA,Hamann JJ,Buckwalter JB,Valic Z

更新日期：2010-01-01 00:00:00

abstract：:Interspecies differences in glycosidation potential in mammalian tissues represent a factor contributing to ambiguity when endobiotic and/or xenobiotic metabolic pathways are extrapolated from animals to man. Using the TLC/autoradiographic technique, we conducted an in vitro investigation involving mouse, rat, monkey,...

journal_title：Physiological research

authors： Cervenková K,Belejová M,Chmela Z,Rypka M,Riegrová D,Michnová K,Michalíková K,Súrová I,Brejcha A,Hanus J,Cerný B,Fuksová K,Havlícek L,Veselý J

更新日期：2003-01-01 00:00:00

abstract：:Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining normal blood pressure, kidney function and water and electrolyte homeostasis. The renal microvasculature expresses a multitude of receptors mediating vasodilation and vasoconstriction, which can influence glomerular blood f...

journal_title：Physiological research

authors： Guan Z,Makled MN,Inscho EW

更新日期：2020-07-16 00:00:00

abstract：:The microcirculation, like all physiological systems undergoes modifications during the course of pregnancy. These changes aid the adaption to the new anatomical and physiological environment of pregnancy and ensure adequate oxygen supply to the fetus. Even though the microcirculation is believed to be involved in maj...

journal_title：Physiological research

authors： Abdo I,George RB,Farrag M,Cerny V,Lehmann C

更新日期：2014-01-01 00:00:00

abstract：:Senile dementia of Alzheimer's type (AD) is commonly characterized as a neurodegenerative disorder, which exhibits gradual changes of consciousness, loss of memory, perception and orientation as well as loss of personality and intellect. AD prevalence increases dramatically with age and is the fourth cause of death in...

journal_title：Physiological research

authors： Rípová D,Strunecká A

更新日期：2001-01-01 00:00:00

abstract：:Impaired cerebrovascular reactivity (CVR), an important risk factor for future stroke, is affected by a presence carotid stenosis. However, in some cases CVR can be impaired in the absence of carotid stenosis due to several poorly characterized mechanisms. We hypothesized that arterial stiffening as observed in corona...

journal_title：Physiological research

authors： Rucka D,Marek J,Rucklova Z,Lubanda JC,Havranek S,Skvaril J,Varejka P,Chochola M,Karetova D,Korinek J,Linhart A

更新日期：2015-01-01 00:00:00

abstract：:Methamphetamine (MA), as a psychostimulant drug that crosses the placental barrier, may disrupt the development of social play. The present study aims to examine the effect of prenatal MA (5 mg/kg) exposure during the first (gestational day (GD) 1-11) or second (GD 12-22) halves of prenatal development of rats on soci...

journal_title：Physiological research

authors： Ševčíková M,Petríková I,Šlamberová R

更新日期：2020-04-30 00:00:00

abstract：:We used a rat model to assess the role of nephrin, podocin, and desmin in the pathogenesis of IgA nephropathy (IgAN). A rat IgAN model was established by administration of BSA, CCl(4), and lipopolysaccharide (LPS) and compared with healthy control rats. Urinary protein, urine red blood cells, and biochemical parameter...

journal_title：Physiological research

authors： Lu H,Chen LL,Jiang XY,Mo Y,Ling YH,Sun LZ

更新日期：2013-01-01 00:00:00

abstract：:Glucose tolerance, insulin binding to erythrocytes, insulinaemia, plasma total cholesterol, plasma triglycerides, weight of fat pads, food consumption and body weight changes were studied in genetically hypertensive lean Koletsky rats. Long-term treatment with dopaminergic agonist terguride (0.2 mg/kg/day) normalized ...

journal_title：Physiological research

authors： Golda V,Hilgertová J

更新日期：1997-01-01 00:00:00