Nanotherapeutics with anthracyclines: methods of determination and quantification of anthracyclines in biological samples.

abstract：:Hypoxic pulmonary vasoconstriction (HPV) occurs in smooth muscle cells (SMC) from small pulmonary arteries (SPA) and is accompanied by increases in free cytoplasmic calcium ([Ca2+]i) and cytoplasmic pH (pHi). SMC from large pulmonary arteries (LPA) relax during hypoxia, and [Ca2+]i and pHi decrease. Increases in pHi a...

journal_title：Physiological research

authors： Madden JA,Keller PA,Kleinman JG

更新日期：2000-01-01 00:00:00

abstract：:Evaluation of possible interactions with enzymes of drug metabolism is an important part of studies on safety and, in general, on the properties of any drug or biologically active compound. Here, focus is given on interactions of three sesquiterpenes (beta-caryophyllene oxide (CAO), trans-nerolidol (tNER) and farnesol...

journal_title：Physiological research

authors： Špičáková A,Bazgier V,Skálová L,Otyepka M,Anzenbacher P

更新日期：2019-11-22 00:00:00

abstract：:Body surface potential maps have and certainly will have a very important role in the field of clinical arrhythmology, specifically for the localization of accessory pathways, for the detection of the origin of ventricular arrhythmias and for the identification of patients at risk of sudden death. In this particular s...

journal_title：Physiological research

authors： De Ambroggi L,Santambrogio C

更新日期：1993-01-01 00:00:00

abstract：:The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. ...

journal_title：Physiological research

authors： Barančík M,Grešová L,Barteková M,Dovinová I

更新日期：2016-09-19 00:00:00

abstract：:Glucose tolerance, insulin binding to erythrocytes, insulinaemia, plasma total cholesterol, plasma triglycerides, weight of fat pads, food consumption and body weight changes were studied in genetically hypertensive lean Koletsky rats. Long-term treatment with dopaminergic agonist terguride (0.2 mg/kg/day) normalized ...

journal_title：Physiological research

authors： Golda V,Hilgertová J

更新日期：1997-01-01 00:00:00

abstract：:Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and...

journal_title：Physiological research

authors： Sedivy P,Dezortova M,Drobny M,Vlasakova Z,Herynek V,Hajek M

更新日期：2018-07-17 00:00:00

abstract：:It has been suggested that thiazolidinediones (TZDs) ameliorate insulin resistance in muscle tissue by suppressing muscle lipid storage and the activity of novel protein kinase C (nPKC) isoforms. To test this hypothesis, we analyzed long-term metabolic effects of pioglitazone and the activation of nPKC-epsilon and -th...

journal_title：Physiological research

authors： Marková I,Zídek V,Musilová A,Šimáková M,Mlejnek P,Kazdová L,Pravenec M

更新日期：2010-01-01 00:00:00

abstract：:Oculometric behaviour assessed by pupil response provides important information about central autonomic activity and emotional regulation. However, studies regarding pupil response to emotional stimuli in adolescent depression are rare. We aimed to study emotional-linked pupil response in adolescent depression. Twenty...

journal_title：Physiological research

authors： Sekaninova N,Ondrejka I,Bona Olexova L,Visnovcova Z,Mestanik M,Cesnekova D,Hamrakova A,Tonhajzerova I

更新日期：2019-12-20 00:00:00

abstract：:We investigated the effects of telmisartan, the blocker of angiotensin II receptor 1, on the regulation of systolic blood pressure (SBP) and oxidative stress through endothelial nitric oxide (NO) release in spontaneously hypertensive rats (SHRs). SHRs randomly received placebo, oral feeding of telmisartan (5 mg/kg or ...

journal_title：Physiological research

authors： Xu L,Liu Y

更新日期：2013-01-01 00:00:00

abstract：:We measured plasma concentrations, adipose tissue and placental mRNA expression of hepatokines fetuin A, fetuin B and fibroblast growth factor 21 (FGF21) in 12 healthy pregnant women (P group), 12 pregnant women with gestational diabetes (GDM) and 10 healthy non-pregnant women (N group) to explore their potential role...

journal_title：Physiological research

authors： Šimják P,Cinkajzlová A,Anderlová K,Kloučková J,Kratochvílová H,Lacinová Z,Kaválková P,Krejčí H,Mráz M,Pařízek A,Kršek M,Haluzík M

更新日期：2018-11-28 00:00:00

abstract：:To predict more precisely the effect of stobadine, a pyridoindole antioxidant agent, in the whole organism, we studied its effect on opsonized zymosan-stimulated free radical generation in whole blood, on superoxide generation in the mixture of PMNL : platelets (1:50), as well as on superoxide generation and myelopero...

journal_title：Physiological research

authors： Pecivová J,Macicková T,Cíz M,Nosál R,Loje A

更新日期：2004-01-01 00:00:00

abstract：:Three-dimensional electrogram was used for analysis of ischemia manifestation in isolated hearts. Three parameters based on spherical coordination system were used in this study - amplitude of electrical heart vector, its azimuth and elevation. The parameters were presented as a trend. This approach reflected ischemic...

journal_title：Physiological research

authors： Janousek O,Kolárová J,Nováková M,Provazník I

更新日期：2010-01-01 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress participate in the development of diabetic complications, however, the mechanisms of their origin are not entirely clear. Coenzyme Q has an important function in mitochondrial bioenergetics and is also a powerful antioxidant. Coenzyme Q (CoQ) regenerates alpha-tocopherol ...

journal_title：Physiological research

authors： Kucharská J,Braunová Z,Ulicná O,Zlatos L,Gvozdjáková A

更新日期：2000-01-01 00:00:00

abstract：:This study was designed primarily to identify relationships among indices of muscle tissue structure (m. vastus lateralis) and of somatic qualities (anthropometric parameters) in 44 untrained men and 105 well-trained athletes. The ratio of glycolytic to oxidative muscle fibres was significantly less (P < 0.05) in endu...

journal_title：Physiological research

authors： Melichna J,Parízková J,Zauner CW,Havlícková L

更新日期：1994-01-01 00:00:00

abstract：:In this retrospective study we analysed changes of the ST segment in patients with arterial hypertension using multi-lead body surface mapping of the electric heart field as the ST segment often shows non-specific changes and is influenced by many different conditions. We constructed isointegral maps (IIM) of chosen i...

journal_title：Physiological research

authors： Kozlíková K,Martinka J,Bulas J

更新日期：2012-01-01 00:00:00

abstract：:Remote ischemic preconditioning (RIPC) is a novel strategy of protection against ischemia-reperfusion (IR) injury in the heart (and/or other organs) by brief episodes of non-lethal IR in a distant organ/tissue. Importantly, RIPC can be induced noninvasively by limitation of blood flow in the extremity implying the app...

journal_title：Physiological research

authors： Ravingerova T,Farkasova V,Griecsova L,Carnicka S,Murarikova M,Barlaka E,Kolar F,Bartekova M,Lonek L,Slezak J,Lazou A

更新日期：2016-09-19 00:00:00

abstract：:Hindlimb unweighting (HU) leads to capillary regression in skeletal muscle. However, the molecular mechanism(s) remains to be elucidated. To gain insight into the regulation of this process, we investigated gene expression of hypoxia-inducible factor-1alpha (HIF-1alpha)vascular endothelial growth factor (VEGF), angiop...

journal_title：Physiological research

authors： Wagatsuma A

更新日期：2008-01-01 00:00:00

abstract：:Both, common gene variants and human adenovirus 36 (Adv36) are involved in the pathogenesis of obesity. The potential relationship between these two pathogenic factors has not yet been investigated. The aim of our study was to examine the association of obesity susceptibility loci with Adv36 status. Genotyping of ten ...

journal_title：Physiological research

authors： Dušátková L,Zamrazilová H,Aldhoon Hainerová I,Atkinson RL,Sedláčková B,Lee ZP,Včelák J,Bendlová B,Kunešová M,Hainer V

更新日期：2015-01-01 00:00:00

abstract：:Recent results of the authors have demonstrated that the elevation of extracellular adenosine induced by the combined administration of dipyridamole, a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), a soluble adenosine prodrug, mediates radioprotective effects in mice. Furthermore...

journal_title：Physiological research

authors： Pospísil M,Hofer M,Vacek A,Netíková J,Pipalová I,Viklická S

更新日期：1993-01-01 00:00:00

abstract：:Circadian oscillations in biological variables in mammals are controlled by a central pacemaker in the suprachiasmatic nuclei (SCN) of the hypothalamus which coordinates circadian oscillators in peripheral tissues. The molecular clockwork responsible for this rhythmicity consists of several clock genes and their corre...

journal_title：Physiological research

authors： Bendová Z,Sumová A

更新日期：2006-01-01 00:00:00

abstract：:Our experiments on metabolic processes in the rumen were performed on sixteen 5-month-old lambs divided into 4 groups (defaunated - D, totally refaunated - T, partially refaunated - P and intact - I). The absence or presence of protozoa in the rumen did not significantly affect the pH values. The greatest differences ...

journal_title：Physiological research

authors： Fejes J,Várady J

更新日期：1996-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of rooibos tea as a natural source of a wide scale of antioxidants on the prevention and treatment of oxidative stress in streptozotocin-induced diabetic rats. Expected significant changes of biochemical parameters characteristic for experimental diabetic state were...

journal_title：Physiological research

authors： Ulicná O,Vancová O,Bozek P,Cársky J,Sebeková K,Boor P,Nakano M,Greksák M

更新日期：2006-01-01 00:00:00

abstract：:MiRNAs are important regulators of gene expression and changes in their levels are linked with various pathological states, including solid tumors. MiR-215 has been identified as a tumor suppressor in colorectal cancer (CRC). Following our previous in vitro and in vivo experiments, the aim of this project was to study...

journal_title：Physiological research

authors： Merhautová J,Vychytilová-Faltejsková P,Demlová R,Slabý O

更新日期：2016-12-21 00:00:00

abstract：:Atrial fibrillation is associated with atrial remodeling, in which connexin 43 (Cx43) and cell hypertrophy play important roles. In this study, apelin-13, an aliphatic peptide, was used to explore the protective effects of the adenosine monophosphate-activated protein kinase (AMPK)/mTOR signaling pathway on Cx43 expre...

journal_title：Physiological research

authors： Chen Y,Qiao X,Zhang L,Li X,Liu Q

更新日期：2020-11-16 00:00:00

abstract：:A "pulse like" increase of cytoplasmic calcium concentration, which is proportional to ionophore concentration, is induced in red cells by exposure to A23187. Different Ca2+ levels are attained depending on cellular calcium buffering power and/or primary active calcium transport activation. We examined the effect of A...

journal_title：Physiological research

authors： Serrani RE,Gioia IA,Corchs JL

更新日期：1995-01-01 00:00:00

abstract：:We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of gamma-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, ...

journal_title：Physiological research

authors： Hofer M,Hoferová Z,Gruzdev A,Dušek L,Falk M

更新日期：2018-11-14 00:00:00

abstract：:In order to examine the relationship between certain risk factors for atherosclerosis and family history of myocardial infarction, we compared a group of children (n = 51) whose parents had survived myocardial infarction (n = 34) with a control group of children (n = 90) with a negative family history of atheroscleros...

journal_title：Physiological research

authors： Raslová K,Hucková M

更新日期：1995-01-01 00:00:00

abstract：:Fibroblast growth factor-21 (FGF-21) has been recently characterized as a new adipokine. The aim of this study was to assess FGF-21 levels in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationship between FGF-21, disease activity and metabolic status. The levels of FGF-21 in seru...

journal_title：Physiological research

authors： Hulejová H,Andrés Cerezo L,Kuklová M,Pecha O,Vondráček T,Pavelka K,Vencovský J,Haluzík M,Senolt L

更新日期：2012-01-01 00:00:00

abstract：:Methamphetamine is one of the most abused hard drugs in the Czech Republic. Its popularity is high not only in Eastern Bloc of Europe but is growing in other countries around the world, including the United States. In addition, methamphetamine abuse increases in drug addicts during pregnancy. Although research into th...

journal_title：Physiological research

authors： Šlamberová R

更新日期：2019-12-20 00:00:00

abstract：:Aquaporin proteins (AQPs) are a family of channels expressed in numerous mammalian tissues, where they play a fundamental role in regulating water transport across cell membranes. Based on reports that AQPs are present in the reproductive system and participate in reproductive processes, our aim was to investigate the...

journal_title：Physiological research

authors： Skowronska A,Mlotkowska P,Majewski M,Nielsen S,Skowronski MT

更新日期：2016-11-08 00:00:00