Reverse transport of cholesterol is the reason for resistance to development of atherosclerosis in Prague Hereditary Hypercholesterolemic (PHHC) rat.

abstract：:Methylphenidate is commonly used for the treatment of attention deficit hyperactivity disorder. The cardiovascular safety of methylphenidate has been a subject of debate with some studies indicating that methylphenidate increases the likelihood of experiencing a myocardial infarction. However, it is unknown whether me...

journal_title：Physiological research

authors： Seeley SL,D'Souza MS,Stoops TS,Rorabaugh BR

更新日期：2020-11-16 00:00:00

abstract：:The main neuromodulatory methods using neurostimulation principles are described. It concerns peripheral nerve stimulation (PNS), spinal cord stimulation (SCS), deep brain stimulation (DBS), motor cortex stimulation (MSC), and repetitive transcranial magnetic stimulation (rTMS). For each method the history, pathophysi...

journal_title：Physiological research

authors： Rokyta R,Fricová J

更新日期：2012-01-01 00:00:00

abstract：:Hepcidin is a key regulator of iron metabolism and plays an important role in many pathologies. It is increased by iron administration and by inflammation, while erythropoiesis downregulates its expression. It decreases iron availability and thus contributes to anemia of chronic diseases. The aim of the study was to m...

journal_title：Physiological research

authors： Přikryl P,Hrušková Z,Konopásek P,Hladinová Z,Tesař V,Vokurka M

更新日期：2018-12-18 00:00:00

abstract：:We used a rat model to assess the role of nephrin, podocin, and desmin in the pathogenesis of IgA nephropathy (IgAN). A rat IgAN model was established by administration of BSA, CCl(4), and lipopolysaccharide (LPS) and compared with healthy control rats. Urinary protein, urine red blood cells, and biochemical parameter...

journal_title：Physiological research

authors： Lu H,Chen LL,Jiang XY,Mo Y,Ling YH,Sun LZ

更新日期：2013-01-01 00:00:00

abstract：:T-2 toxin and its metabolite HT-2 toxin are one of the most toxic mycotoxins of type A-trichothecenes, which are produced mainly by Fusarium species. Therefore, study of Fusarium toxins T-2 toxin and HT-2 toxin is an essential issue because they could also play role in failures of reproductive functions as well as end...

journal_title：Physiological research

authors： Kolesarova A,Maruniakova N,Kadasi A,Halenar M,Marak M,Sirotkin AV

更新日期：2017-09-22 00:00:00

abstract：:We investigated the influence of oxygenation of in vitro lung preparation on the pulmonary vascular reactivity. Small pulmonary vessels isolated from adult male Wistar rats exposed for 4 days to hypoxia (F(iO2) = 0.1, group CH) were compared with those of normoxic controls (group N). The bath in the chamber of small v...

journal_title：Physiological research

authors： Zaloudíková M,Vízek M,Herget J

更新日期：2009-01-01 00:00:00

abstract：:Clusterin is a heterodimeric glycoprotein with wide range of functions. To further explore its possible regulatory role in energy homeostasis and in adipose tissue, we measured plasma clusterin and its mRNA expression in subcutaneous adipose tissue (SCAT) of 15 healthy lean women, 15 obese women (OB) and 15 obese wome...

journal_title：Physiological research

authors： Kloučková J,Lacinová Z,Kaválková P,Trachta P,Kasalický M,Haluzíková D,Mráz M,Haluzík M

更新日期：2016-07-18 00:00:00

abstract：:The influence of chronic angiotensin AT1 receptor blockade by specific antibody on the development of genetic hypertension was studied in young spontaneously hypertensive rats (SHR). The immunization of 4-week-old SHR with a small part of the angiotensin AT1 receptor molecule attenuated the development of hypertension...

journal_title：Physiological research

authors： Zelezná B,Velek J,Veselský L,Zicha J,Dobesová Z,Kunes J

更新日期：1996-01-01 00:00:00

abstract：:We investigated how postural responses to galvanic vestibular stimulation were affected by standing on a translating support surface and by somatosensory loss due to diabetic neuropathy. We tested the hypothesis that an unstable surface and somatosensory loss can result in an increase of vestibulospinal sensitivity. B...

journal_title：Physiological research

authors： Hlavacka F,Horak FB

更新日期：2006-01-01 00:00:00

abstract：:It has been reported that the major function of the sterol regulatory element binding protein 2 (SREBP-2) is to activate preferentially cholesterol biosynthesis in liver and adipose tissue rather than fatty acid synthesis. In the current study, we analyzed the effects of overexpression of human dominant-positive SREBP...

journal_title：Physiological research

authors： Landa V,Zídek V,Mlejnek P,Šimáková M,Šilhavý J,Trnovská J,Kazdová L,Pravenec M

更新日期：2014-01-01 00:00:00

abstract：:Photodynamic therapy (PDT) is now being used more frequently in carefully selected cases of malignancies. The drugs used for PDT are mostly derivatives of haematoporphyrine (HPD) and its active component photofrine II. Another compound prepared by total synthesis is meso-tetra-(4-sulfonatophenyl)-porphine (TPPS4) but ...

journal_title：Physiological research

authors： Zima T,Jirsa M,Jirsa M Jr,Bradová V,Stejskal J,Zabka J,Povýsil C,Janebová M

更新日期：1997-01-01 00:00:00

abstract：:The method of cellular immobilization and perfusion was applied to adipocytes. The lipolytic effect of isoprenaline, whose action is produced as a result of receptor-drug interaction, was followed. An agarose solution kept at at 37 degrees C was mixed 1:1 with the cell suspension. Thereafter, adipocytes were immobiliz...

journal_title：Physiological research

authors： Lincová D,Miseková D,Farghali H,Martínek J,Hynie S

更新日期：1994-01-01 00:00:00

abstract：:The effects of inclusion of sesamin / episesamin in Baltic Atlantic salmon (Salmo salar L.) diets based on vegetable oils were studied. The study was designed as a dose response study with two control diets, one diet based on fish oil (FO) and one diet based on a mixture of linseed and sunflower oil (6:4 by vol.) (MO)...

journal_title：Physiological research

authors： Trattner S,Ruyter B,Ostbye TK,Kamal-Eldin A,Moazzami A,Pan J,Gjoen T,Brännäs E,Zlabek V,Pickova J

更新日期：2011-01-01 00:00:00

abstract：:The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in t...

journal_title：Physiological research

authors： Ziaaldini MM,Hosseini SR,Fathi M

更新日期：2017-03-31 00:00:00

abstract：:We report that decreased expression of miR-30c in tumor compared to adjacent tissue is sex-dependent in colorectal cancer (CRC) patients. High expression of miR-30c was associated with better survival in the whole cohort. When the cohort was split into male and female subcohorts, decreased miR-30c expression in tumor ...

journal_title：Physiological research

authors： Herichova I,Reis R,Hasakova K,Vician M

更新日期：2020-12-31 00:00:00

abstract：:Three-dimensional electrogram was used for analysis of ischemia manifestation in isolated hearts. Three parameters based on spherical coordination system were used in this study - amplitude of electrical heart vector, its azimuth and elevation. The parameters were presented as a trend. This approach reflected ischemic...

journal_title：Physiological research

authors： Janousek O,Kolárová J,Nováková M,Provazník I

更新日期：2010-01-01 00:00:00

abstract：:We analyzed the effect of FK 506 on the production of nitric oxide by macrophages. Isolated rat peritoneal macrophages were cultured for 24 h with or without lipopolysaccharide (LPS) (5 microg/ml) and in the absence or presence of FK 506 (0.1 and 1 microg/ml). The concentration of NO2- in culture supernatants was take...

journal_title：Physiological research

authors： Strestíková P,Otová B,Filipec M,Farghali H

更新日期：2000-01-01 00:00:00

abstract：:The influence of a subconvulsant dose of kainic acid (KA) on the activity of neurons was studied in the sensorimotor cortical area of urethane-anesthetized rats. A total of 41 neurons was recorded, 38 of these in layer V (probably pyramidal cells). The activity of 18 neurons was recorded before as well as more than 30...

journal_title：Physiological research

authors： Konrád M,Pavlík V,Mares P

更新日期：1999-01-01 00:00:00

abstract：:Pulse dye densitometry (PDD) enables the evaluation of hemodynamic state as well as liver function. A repeated examination, even after a short pause (or under stress condition), enables to follow safely the dynamics of liver pathology. From presented parameters we have evaluated as reliable the C5-clearance, an expres...

journal_title：Physiological research

authors： Tichý JA,Loucka M,Trefný ZM,Hojerová M,Svacinka J,Müller J,Friedrichová M

更新日期：2009-01-01 00:00:00

abstract：:Ischemic postconditioning and remote conditioning are potentially useful tools for protecting ischemic myocardium. This study tested the hypothesis that 2,3-dehydrosilybin (DHS), a flavonolignan component of Silybum marianum, could attenuate cardiomyocyte damage following hypoxia/reoxygenation by decreasing the genera...

journal_title：Physiological research

authors： Gabrielová E,Křen V,Jabůrek M,Modrianský M

更新日期：2015-01-01 00:00:00

abstract：:Spontaneous activity of cortical neurons exhibits alternative fluctuations of membrane potential consisting of phased depolarization called "up-state" and persistent hyperpolarization called "down-state" during slow wave sleep and anesthesia. Here, we examined the effects of sound stimuli (noise bursts) on neuronal ac...

journal_title：Physiological research

authors： Zhang Y,Han L,Xiao X,Hu B,Ruan H,Xiong Y

更新日期：2011-01-01 00:00:00

abstract：:Vascular aging is associated with both structural and functional changes that can take place at the level of the endothelium, vascular smooth muscle cells and the extracellular matrix of blood vessels. With regard to the endothelium, reduced vasodilatation in response to agonists occurs in large conduit arteries as we...

journal_title：Physiological research

authors： Matz RL,Schott C,Stoclet JC,Andriantsitohaina R

更新日期：2000-01-01 00:00:00

abstract：:Oculometric behaviour assessed by pupil response provides important information about central autonomic activity and emotional regulation. However, studies regarding pupil response to emotional stimuli in adolescent depression are rare. We aimed to study emotional-linked pupil response in adolescent depression. Twenty...

journal_title：Physiological research

authors： Sekaninova N,Ondrejka I,Bona Olexova L,Visnovcova Z,Mestanik M,Cesnekova D,Hamrakova A,Tonhajzerova I

更新日期：2019-12-20 00:00:00

abstract：:The concept of vena contracta space reduction in tricuspid valve position was tested in an animal model. Feasibility of specific artificial obturator body (REMOT) fixed to the right ventricular apex and interacting with tricuspid valve leaflets was evaluated in three different animal studies. Catheter-based technique ...

journal_title：Physiological research

authors： Sochman J,Peregrin JH,Pavcnik D,Uchida BT,Timmermans HA,Sedmera D,Benada O,Kofronova O,Keller FS,Rosch J

更新日期：2014-01-01 00:00:00

abstract：:Whole blood surface tension of 15 healthy subjects recorded by the ring method was investigated in the temperature range from 20 to 40 degrees C. The surface tension omega as a function of temperature t ( degrees C) is described by an equation of linear regression as omega(t) = (-0.473 t + 70.105) x 10(-3) N/m. Blood ...

journal_title：Physiological research

authors： Rosina J,Kvasnák E,Suta D,Kolárová H,Málek J,Krajci L

更新日期：2007-01-01 00:00:00

abstract：:Brain imaging studies suggest localization of verbal working memory in the left dorsolateral prefrontal cortex (DLPFC) while face processing and memory is localized in the inferior temporal cortex and other brain areas. The goal of this study was to assess the effect of left DLPFC low-frequency repetitive transcranial...

journal_title：Physiological research

authors： Skrdlantová L,Horácek J,Dockery C,Lukavský J,Kopecek M,Preiss M,Novák T,Höschl C

更新日期：2005-01-01 00:00:00

abstract：:The most common etiology of non-syndromic monogenic obesity are mutations in gene for the Melanocortin-4 receptor (MC485) with variable prevalence in different countries (1.2-6.3 % of obese children). The aim of our study was 1) to search for MC4R mutations in obese children in Slovakia and compare their prevalence wi...

journal_title：Physiological research

authors： Stanikova D,Surova M,Ticha L,Petrasova M,Virgova D,Huckova M,Skopkova M,Lobotkova D,Valentinova L,Mokan M,Stanik J,Klimes I,Gasperikova D

更新日期：2015-01-01 00:00:00

abstract：:Important fetal and perinatal pathologies, especially intrauterine growth restriction (IUGR), are thought to stem from placental hypoxia-induced vasoconstriction of the fetoplacental vessels, leading to placental hypoperfusion and thus fetal undernutrition. However, the effects of hypoxia on the fetoplacental vessels ...

journal_title：Physiological research

authors： Hampl V,Jakoubek V

更新日期：2009-01-01 00:00:00

abstract：:Vascular stenosis is often described only by its percentage in both clinical and scientific praxis. Previous studies gave inconclusive results regarding the effect of stenosis eccentricity on its hemodynamic effect. The aim of this experimental study was to investigate and quantify the effect of stenosis severity and ...

journal_title：Physiological research

authors： Novakova L,Kolinsky J,Adamec J,Kudlicka J,Malik J

更新日期：2016-01-01 00:00:00

abstract：:Laboratory rats were exposed to the inhalation of dust from an agglomeration unit which is the greatest contributor to dust pollution in the vicinity of a mercury producing plant. The exposure lasted for 6 months (4 hours daily, 5 days per week), the concentration of aerosol in the chamber was 10 mg x m(-3). After fin...

journal_title：Physiological research

authors： Kováciková Z,Chorvatovicová D

更新日期：1997-01-01 00:00:00